FlyBase Gene Report: Dmel\Dbx

General Information

Symbol

Dmel\Dbx

Species

D. melanogaster

Name

Dbx

Annotation Symbol

CG42234

Feature Type

protein_coding_gene

FlyBase ID

FBgn0261723

Gene Model Status

Current

Stock Availability

35 publicly available

Gene Summary

Dbx (Dbx) encodes a homedomain transcription factor expressed in distinct subsets of interneurons. It helps control the differentiation of these neurons, which tend to extend short axons and be GABA-ergic, via cross-repressive interactions with the products of exex and eve. The roles of the product of Dbx include neuronal specification and differentiation. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Key Links

Genomic Location

Cytogenetic map

62B10-62B11

Sequence location

3L:1,921,307..1,933,602 [+]

Recombination map

3-1.0

RefSeq locus

NT_037436 REGION:1921307..1933602

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA binding

inferred from electronic annotation with InterPro:IPR000047, InterPro:IPR001356

(InterPro Project Members, 2004-)

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from electronic annotation with InterPro:IPR017970

(InterPro Project Members, 2004-)

Biological Process (4 terms)

Terms Based on Experimental Evidence (2 terms)

CV Term

Evidence

References

involved_in axon guidance

inferred from mutant phenotype

(Lacin et al., 2009)

involved_in neuron fate commitment

inferred from mutant phenotype

(Lacin et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in regulation of DNA-templated transcription

inferred from electronic annotation with InterPro:IPR017970

(InterPro Project Members, 2004-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000677682

(GO Reference Genome Project, 2011-)

Cellular Component (0 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (0 terms)

Gene Group (FlyBase)

NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

NK-LIKE HOMEOBOX TRANSCRIPTION FACTORS -: NK-like (NKL) homeobox transcription factors are sequence-specific DNA binding proteins that regulate transcription. NKL transcription factors are homeobox genes closely related to Hox-like genes, a number of which are found in the NK cluster. Many of the NKL members contain an Engrailed Homology 1 (EH1) motif. (Adapted from FBrf0232555 and PMID:22094586).

Summary (Interactive Fly)

homeobox gene - contributes to the development of subsets of interneurons via cross-repressive, lineage-specific interactions with the motoneuron-promoting factors eve and exex

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Dbx for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9W064)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.46

Gene model reviewed during 5.55

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Dbx-RC

FBtr0290136

NM_139420

2488

741

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Dbx-PC

FBpp0288576

81.2

741

7.00

Q9W064

NP_647677

AAF47594

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9W064

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Dbx using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dbx_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.58

Transcript Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage

neuroblast NB4-2

(Lacin and Truman, 2016)

neuroblast NB6-1

(Lacin and Truman, 2016)

neuroblast NB6-2

(Lacin and Truman, 2016)

neuroblast NB7-1

(Lacin and Truman, 2016)

embryonic stage -- larval stage

neuroblast NB3-2

(Lacin and Truman, 2016)

neuroblast NB7-2

(Lacin and Truman, 2016)

larval stage

neuroblast NB4-2

(Lacin and Truman, 2016)

neuroblast NB6-1

(Lacin and Truman, 2016)

neuroblast NB6-2

(Lacin and Truman, 2016)

neuroblast NB7-1

(Lacin and Truman, 2016)

Additional Descriptive Data

Marker for

neuroblast NB3-2

(Lacin and Truman, 2016)

neuroblast NB6-1

(Lacin and Truman, 2016)

neuroblast NB7-2

(Lacin and Truman, 2016)

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

Reporter: Mi{Trojan-GAL4DBD.0}Dbx^{MI05316-TG4DBD.0}

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

Notch OFF hemilineage neuron of NB3-2 lineage neuron

Comment: when combined with Mi{Trojan-p65AD.0}ey^{MI08729-Tp65AD.0}

(Lacin et al., 2020)

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Dbx in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Dbx

View exonic expression by tissue for Dmel\Dbx

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261723

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38254/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261723

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0250756

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261723

Flygut - An atlas of the Drosophila adult midgut

FBgn0261723

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Dbx

Transgenic constructs containing regulatory region of Dbx

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(3L)R-G7

(Lacin et al., 2009)

Inferred from location ( 8 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

viable

Dbx^Δ48

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Dbx^GD4315

viable, with Scer\GAL4^Mef2.PR

Dbx^GD4315

viable, with Scer\GAL4^pnr-MD237

Dbx^GD4315

viable, with Scer\GAL4^tin.CΔ4

Dbx^GD4315

Sterility

Allele

fertile

Dbx^Δ48

Other Phenotypes

Allele

abnormal locomotor behavior

Dbx^Δ48

abnormal neuroanatomy, with Scer\GAL4^elav-C155

Dbx^UAS.fl

abnormal neuroanatomy | late embryonic stage

Dbx^Δ48

abnormal neuroanatomy | late embryonic stage, with Scer\GAL4^elav-C155

Dbx^{UAS.ORF.GW.Tag:HA}

decreased cell number | late embryonic stage

Dbx^Δ48

decreased cell number | late embryonic stage, with Scer\GAL4^elav-C155

Dbx^{UAS.ORF.GW.Tag:HA}

flightless

Dbx^Δ48

visible, with Scer\GAL4^Bx-MS1096

Dbx^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

apterous-expressing neuron of the lateral cluster of the thorax | late embryonic stage

Dbx^Δ48

apterous-expressing neuron of the lateral cluster of the thorax | late embryonic stage, with Scer\GAL4^elav-C155

Dbx^{UAS.ORF.GW.Tag:HA}

larval intersegmental nerve, with Scer\GAL4^elav-C155

Dbx^UAS.fl

larval intersegmental nerve branch ISNb of A1-7, with Scer\GAL4^elav-C155

Dbx^UAS.fl

larval longitudinal connective, with Scer\GAL4^elav-C155

Dbx^UAS.fl

larval segmental nerve branch SNc of A1-7, with Scer\GAL4^elav-C155

Dbx^UAS.fl

tract, with Scer\GAL4^elav-C155

Dbx^UAS.fl

wing, with Scer\GAL4^Bx-MS1096

Dbx^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (172)

Hsap\DBX1

9 of 14

Yes

Hsap\DBX2

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\DUX3

1 of 14

Yes

Hsap\DUX4

1 of 14

Hsap\DUX4L4

1 of 14

Yes

Hsap\DUX4L7

1 of 14

Yes

Hsap\DUX4L9

1 of 14

Yes

Hsap\DUX5

1 of 14

Yes

Hsap\DUXA

1 of 14

Yes

Hsap\DUXB

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Hsap\HOXD9

1 of 14

Hsap\HOXD12

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (139)

Rnor\Dbx1

9 of 14

Yes

Rnor\Dbx2

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Rnor\LOC691325

1 of 14

Rnor\LOC100361016

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (146)

Mmus\Dbx1

9 of 14

Yes

Mmus\Dbx2

5 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Mmus\Rhox10

1 of 14

Mmus\Sebox

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (153)

Xtro\dbx1

6 of 13

Yes

Xtro\dbx2

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

Yes

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Xtro\homeobox100496651-provisional

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\hoxc13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\sia3

1 of 13

Yes

Xtro\six3

1 of 13

Xtro\six4

1 of 13

Xtro\soho1

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Danio rerio (Zebrafish) (196)

Drer\dbx1a

9 of 14

Yes

Drer\dbx1b

9 of 14

Yes

Drer\dbx2

3 of 14

Yes

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\hoxa13b

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

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1 of 14

1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

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1 of 14

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1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Drer\zgc:101100

1 of 14

Drer\zhx2a

1 of 14

Yes

Caenorhabditis elegans (Nematode, roundworm) (63)

Cele\ceh-1

2 of 14

Yes

Cele\ceh-2

2 of 14

Yes

Cele\ceh-13

2 of 14

Yes

Cele\ceh-23

2 of 14

Yes

Cele\ceh-30

2 of 14

Yes

Cele\ceh-51

2 of 14

Yes

Cele\cog-1

2 of 14

Yes

Cele\dsc-1

2 of 14

Yes

Cele\lin-39

2 of 14

Yes

Cele\mab-5

2 of 14

Yes

Cele\php-3

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Cele\egl-5

1 of 14

Cele\eyg-1

1 of 14

Cele\hmbx-1

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (67)

Agam\AgaP_AGAP005727

9 of 12

Yes

3 of 12

3 of 12

3 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (52)

Atha\ATHB13

3 of 13

Yes

Atha\AtHB23

3 of 13

Yes

Atha\ATHB54

3 of 13

Yes

Atha\HAT1

3 of 13

Yes

Atha\HAT2

3 of 13

Yes

Atha\HAT3

3 of 13

Yes

Atha\HAT9

3 of 13

Yes

Atha\HAT14

3 of 13

Yes

Atha\HAT22

3 of 13

Yes

Atha\HB-1

3 of 13

Yes

Atha\HB-2

3 of 13

Yes

Atha\HB-3

3 of 13

Yes

Atha\HB4

3 of 13

Yes

Atha\HB5

3 of 13

Yes

Atha\HB6

3 of 13

Yes

Atha\HB-7

3 of 13

Yes

Atha\HB-12

3 of 13

Yes

Atha\HB16

3 of 13

Yes

Atha\HB17

3 of 13

Yes

Atha\HB18

3 of 13

Yes

Atha\HB20

3 of 13

Yes

Atha\HB22

3 of 13

Yes

Atha\HB51

3 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Atha\WOX14

1 of 13

Yes

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\YHP1

2 of 13

Yes

Scer\YOX1

2 of 13

Yes

Scer\HMRA1

1 of 13

Yes

Scer\PHO2

1 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\phx1

2 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Dbx. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (88)

H2.0

5 of 13

B-H2

4 of 13

btn

4 of 13

cad

4 of 13

ems

4 of 13

HGTX

4 of 13

lms

4 of 13

unpg

4 of 13

zen2

4 of 13

Antp

3 of 13

bcd

3 of 13

B-H1

3 of 13

bsh

3 of 13

C15

3 of 13

CG11085

3 of 13

CG18599

3 of 13

CG34031

3 of 13

Dfd

3 of 13

eve

3 of 13

exex

3 of 13

ftz

3 of 13

HHEX

3 of 13

Hmx

3 of 13

inv

3 of 13

lab

3 of 13

lbe

3 of 13

lbl

3 of 13

NK7.1

3 of 13

Scr

3 of 13

slou

3 of 13

tin

3 of 13

zen

3 of 13

abd-A

2 of 13

Abd-B

2 of 13

Awh

2 of 13

bap

2 of 13

CG11294

2 of 13

CG15696

2 of 13

CG34367

2 of 13

Dll

2 of 13

Drgx

2 of 13

hbn

2 of 13

ind

2 of 13

Lim1

2 of 13

Lim3

2 of 13

otp

2 of 13

Pph13

2 of 13

Ptx1

2 of 13

scro

2 of 13

Ubx

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

exd

1 of 13

eyg

1 of 13

gsb

1 of 13

gsb-n

1 of 13

Gsc

1 of 13

Lmx1a

1 of 13

nub

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

prd

1 of 13

repo

1 of 13

Six4

1 of 13

toe

1 of 13

toy

1 of 13

tup

1 of 13

vnd

1 of 13

Vsx1

1 of 13

Vsx2

1 of 13

vvl

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

DBX1; developing brain homeobox 1

9 of 14

619830

DBX2; developing brain homeobox 2

5 of 14

620706

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Dbx - NC2β

two hybrid array

(Shokri et al., 2019)

Dbx - trr

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Linkouts

DroID - A comprehensive database of gene and protein interactions.

FBgn0261723

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Class of Gene

gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-1.0

Cytogenetic map

62B10-62B11

Sequence location

3L:1,921,307..1,933,602 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

62B10-62B11

Limits computationally determined from genome sequence between P{PZ}dlt⁰⁴²⁷⁶ and P{PZ}sls^rL182

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-1.0

(FlyBase, 2016)

3-3.4

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (35)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

56826

w¹¹¹⁸; P{UAS-dbx.fl}3

40675

w¹¹¹⁸; P{GMR94B04-GAL4}attP2

40676

w¹¹¹⁸; P{GMR94B06-GAL4}attP2

49805

w¹¹¹⁸; P{GMR34H05-GAL4}attP2

49823

w¹¹¹⁸; P{GMR35C01-GAL4}attP2

68460

w¹¹¹⁸; P{R94B04-p65.AD}attP40

68617

w¹¹¹⁸; P{R94B06-GAL4.DBD}attP2

FlyORF

F001875

M{UAS-Dbx.ORF.3xHA.GW}ZH-86Fb

Korea

16274

P{GMR34H05-lexA}attP2

VDRC

v102396

P{KK110526}VIE-260B

v104389

P{KK108137}VIE-260B

v318040

PBac{fTRG00121.sfGFP-TVPTBF}VK00033

More stocks available...

Genomic Clones (16)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (1)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0261723

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0261723

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Lacin et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Misexpression of Dbx severely disrupts neuronal fates.

(Broihier et al., 2002)

Identification: Comparative genomic approach to identify and screen potential regulators of eve and exex.

(Broihier et al., 2002)

Relationship to Other Genes

Source for database merge of

Source for merge of: CG13925 CG12361

(FlyBase Genome Annotators, 2008)

Source for merge of: Dbx CG42234

(Lacin et al., 2009)

Additional comments

Annotations CG13925 and CG12361 merged as CG42234 in release 5.6 of the genome annotation.

(FlyBase Genome Annotators, 2008)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

Name Synonyms

CG12361

CG13925

Dbx

Secondary FlyBase IDs

FBgn0062390
FBgn0250756
FBgn0035291
FBgn0035292

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 27 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

38254

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

AAF47594

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9W064

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Q9W064

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9W064

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0261723

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

38254/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0261723

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0261723

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG42234

MARRVEL_MODEL - MARRVEL (model organism gene)

38254

Linkouts

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0261723

DroID - A comprehensive database of gene and protein interactions.

FBgn0261723

DRSC - Results frm RNAi screens

FBgn0261723

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Dbx_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0250756

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0261723

Flygut - An atlas of the Drosophila adult midgut

FBgn0261723

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC034733

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

References (55)

The following external sites may use different assemblies or annotations than FlyBase.

-0.58

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