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FB2026_01
,
released March 12, 2026
W26, bk24
homeodomain transcription factor - involved hindgut development of Drosophila, downstream factor of branchyenteron
Please see the JBrowse view of Dmel\otp for information on other features
To submit a correction to a gene model please use the Contact FlyBase form
AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.51
Stop-codon suppression (UGA) postulated; FBrf0234051.
Gene model reviewed during 6.25
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\otp using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: reported as large intestine specific anlage
The earliest otp expression is visible in the the proctodeum at embryonic stage 9. otp expression in the nervous system begins at stage 10 and expression in the hindgut, anal pads, ventral nerve cord, and brain is observed at stage 14. Expression is also observed in the rectum, at a lower leve than in the other parts of the hindgut. In the nervous system, there is a clear border with a higher level of otp expression in the five most anterior segments of the ventral nerve cord and a lower level in the posterior segments of the ventral nerve cord. Expression in the nervous system is specific to the larger 2.9kb alternative transcript that starts with exon 1 (e.g. otp-RE). Expression in the hindgut primordium, embryonic hindgut and anal pads is specific to the smaller 2.3kb transcripts (e.g. otp-RC) that initiates at exon 3.
otp protein expression is first observed in the proctodeum at embryonic stage 10. By stage 14, it is observed in the hindgut, anal pads, ventral nerve cord, and brain. In the ventral nerve cord, expression is only observed up to segment A2 and not in more posteriorly-located segments. In the embryonic brain, expression was seen in three discrete expression domains per hemisphere, two (P1 and P2) in the protocerebrum and one (D1) in the deutocerebrum. The expression domains consist of 10 (P1), 3 (P2) and 5 (D1) neurons. otp protein is also expressed in the larval and adult ileum and rectum but not in the pylorus.
JBrowse - Visual display of RNA-Seq signals
View Dmel\otp in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Annotations CG10036, CG2965 merged as CG10036 in release 3 of the genome annotation, April 2002.
Homologous genetic loci in D.subobscura and D.melanogaster tend to show a similar ultrastructure in the two species.
One of the homeodomain loci identified in a screen for genes encoding DNA binding proteins capable of binding to a consensus Engrailed binding site.
otp is necessary for hindgut formation.
otp has been isolated and its expression pattern analysed.
Source for merge of: otp BcDNA:RE58095
Source for merge of otp BcDNA:RE58095 was a shared cDNA ( date:030728 ).
