FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\DbxΔ48
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General Information
Symbol
Dmel\DbxΔ48
Species
D. melanogaster
Name
FlyBase ID
FBal0241892
Feature type
allele
Associated gene
Dmel\Dbx
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
P-element activity
(Lacin et al., 2009)
Progenitor genotype
DbxKG00100
(Lacin et al., 2009)
Cytology
Description

Mobilisation of P{SUPor-P}DbxKG00100 results in a 2.2kb deletion that removes the Dbx transcription start site.

(Lacin et al., 2009)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3L:1,919,074..1,921,384 [+]
Comment:

2311bp deletion resulting from the excision of P{SUPor-P}DbxKG00100 that removes the Dbx transcription start site. Deletion endpoints determined from reported flanking sequences.

(Lacin et al., 2009)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      DbxΔ48/DbxΔ48 embryos display significantly lower numbers of ap-expressing neurons than controls. The remaining ap-expressing neurons fail to extend towards the medial-most Fas2-immunopositive fascicle in the ventral nerve cord, without impacting the overall organization of the Fas2-immunopositive scaffold.

      (Stratmann et al., 2019)

      Homozygous DbxΔ48 flies are viable, fertile and exhibit locomotor phenotypes. They are sessile and uncoordinated, perform poorly in climbing assays, and although they initiate a flight response, they can not maintain flight.

      (Lacin et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      DbxD48
      (Stratmann et al., 2019)
      DbxΔ48
      Name Synonyms
      Secondary FlyBase IDs
        References (2)