a critical regulator of adult intestinal stem cell differentiation - required for differentiation of enteroblast progenitors into absorptive enterocytes - depletion inhibits ISC proliferation via cell cycle arrest, while overexpression inhibits ISC proliferation by directly suppressing EGFR expression - testes differentiation
Gene model reviewed during 5.47
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sox100B using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\Sox100B in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Annotations CG15552 and CG12098 merged as CG15552 in release 3 of the genome annotation.
Source for merge of Sox100B CG12098 was sequence comparison ( date:000607 ).
Source for merge of Sox100B CG18674 was sequence comparison ( date:001216 ).