FlyBase Gene Report: Dmel\Sox100B

General Information

Symbol

Dmel\Sox100B

Species

D. melanogaster

Name

Sox100B

Annotation Symbol

CG15552

Feature Type

protein_coding_gene

FlyBase ID

FBgn0024288

Gene Model Status

Current

Stock Availability

17 publicly available

Gene Summary

Sox100B (Sox100B) encodes a group E Sox domain transcription factor. It has a role in the development of somatic components of the testis during metamorphosis, where it regulates pigment cell specification. Sox100B shows sexually dimorphic expression in the embryonic gonad. [Date last reviewed: 2018-09-20] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

SoxB

Key Links

Genomic Location

Cytogenetic map

100B2-100B2

Sequence location

3R:31,065,253..31,083,407 [+]

Recombination map

3-102

RefSeq locus

NT_033777 REGION:31065253..31083407

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (5 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002910095

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002910095

(GO Reference Genome Project, 2011-)

Biological Process (2 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in male gonad development

inferred from mutant phenotype

(Nanda et al., 2009)

inferred from expression pattern

(DeFalco et al., 2003)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN002910095

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002910095

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -: The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).

Summary (Interactive Fly)

a critical regulator of adult intestinal stem cell differentiation - required for differentiation of enteroblast progenitors into absorptive enterocytes - depletion inhibits ISC proliferation via cell cycle arrest, while overexpression inhibits ISC proliferation by directly suppressing EGFR expression - testes differentiation

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sox100B for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VA17)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sox100B-RA

FBtr0085735

NM_143582

2049

529

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sox100B-PA

FBpp0085097

57.1

529

7.36

Q9VA17

NP_651839

AAF57112

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sox100B using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sox100B_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

0.04

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 11 -- 12

anal pad primordium

Comment: reported as anal pad specific anlage

(Fisher et al., 2012)

hindgut proper primordium

(Fisher et al., 2012)

Malpighian tubule primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic anal pad

(Fisher et al., 2012)

embryonic hindgut

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 15

testis

(Nanda et al., 2009)

embryonic stage 17

testis pigment cell

(Nanda et al., 2009, DeFalco et al., 2008)

gonadal sheath proper primordium

(DeFalco et al., 2008)

gonadal sheath

(DeFalco et al., 2008)

larval stage

testis pigment cell

(Nanda et al., 2009)

pupal stage

testis pigment cell

(Nanda et al., 2009)

adult stage | male

testis pigment cell

(Nanda et al., 2009)

adult stage | female

ovary

(Nanda et al., 2009)

germarium cap cell

(Nanda et al., 2009)

terminal filament

(Nanda et al., 2009)

stalk follicle cell

(Nanda et al., 2009)

Additional Descriptive Data

Expressed in both somatic gonadal precursors and ensheathing cells in stage 17 embryos. Expressed in testis pigment cells in adults.

(DeFalco et al., 2008)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sox100B in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sox100B

View exonic expression by tissue for Dmel\Sox100B

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024288

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45039/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024288

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024288

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024288

Flygut - An atlas of the Drosophila adult midgut

FBgn0024288

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 13 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sox100B

Transgenic constructs containing regulatory region of Sox100B

Aberrations (Deficiencies and Duplications) ( 6 )

Inferred from experimentation ( 6 )

Gene disrupted in

Df(3R)Exel6260

(Ryder, 2004.4.26)

Df(3R)j3B9-rv12

(Nanda et al., 2009, Loh, 1999)

Gene partially disrupted in

Df(3R)j3B9-rv9

(Nanda et al., 2009)

Df(3R)j3B9-rv12

(DeFalco et al., 2003)

Df(3R)j3B9-rvB

(Nanda et al., 2009)

Df(3R)j3B9-rvL

(Nanda et al., 2009)

Gene not disrupted in

Df(3R)tll-g

(Nanda et al., 2009)

Inferred from location ( 2 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Df(3R)tll-e)

lethal (with Sox100B^d1)

Sox100B^d2

lethal (with Sox100B^d2)

Sox100B^d1

lethal | male limited, with Scer\GAL4^Bx-MS1096

Sox100B^{UAS.ORF.GW.Tag:HA}

lethal | male limited | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox100B^{UAS.ORF.GW.Tag:HA}

lethal - all die before end of P-stage | recessive

lethal - all die before end of pupal stage, with Scer\GAL4^{CG13917-BG01278}

Sox100B^GLV21021

lethal - all die before end of pupal stage, with Scer\GAL4^pnr-MD237

Sox100B^GD4588

lethal - all die during P-stage, with Scer\GAL4^Mef2.PR

Sox100B^GD4588

Other Phenotypes

Allele

abnormal cell number | adult stage, with Scer\GAL4^Su(H).GBE

Sox100B^GD4588

abnormal cell number | adult stage | somatic clone, with Scer\GAL4^Act.PU

Sox100B^GD4588

decreased cell number | adult stage | progressive

Sox100B^del1

decreased cell number | adult stage | somatic clone

Sox100B^del1

decreased cell number | adult stage | somatic clone, with Scer\GAL4^Act.PU

decreased cell size | adult stage | somatic clone

Sox100B^d1

decreased occurrence of cell division | adult stage

Sox100B^del1

decreased occurrence of cell division | adult stage, with Scer\GAL4^{Delta-05151-G}

decreased occurrence of cell division | adult stage, with Scer\GAL4^NP5130

increased cell number | adult stage, with Scer\GAL4^Su(H).GBE

Sox100B^UAS.cJa

increased cell number | adult stage | somatic clone

Sox100B^d1

increased occurrence of cell division | adult stage, with Scer\GAL4^esg.PU

some die during pupal stage, with Scer\GAL4^pnr-MD237

Sox100B^GD4588

visible | female limited, with Scer\GAL4^Bx-MS1096

Sox100B^{UAS.ORF.GW.Tag:HA}

visible | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox100B^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

adult enterocyte | increased number, with Scer\GAL4^Su(H).GBE

Sox100B^UAS.cJa

adult enteroendocrine cell | decreased number | somatic clone

Sox100B^del1

adult enteroendocrine cell | decreased number | somatic clone, with Scer\GAL4^Act.PU

adult gut, with Scer\GAL4^esg.PU

adult midgut enterocyte | decreased number, with Scer\GAL4^Su(H).GBE

Sox100B^GD4588

adult midgut enterocyte | decreased number | somatic clone

Sox100B^del1

adult midgut enterocyte | decreased number | somatic clone, with Scer\GAL4^Act.PU

adult midgut epithelium, with Scer\GAL4^NP5130

Sox100B^GD4588

adult midgut epithelium | adult stage

Sox100B^del1

adult midgut epithelium | adult stage, with Scer\GAL4^{Delta-05151-G}

adult midgut epithelium | adult stage, with Scer\GAL4^NP5130

adult midgut epithelium | adult stage | somatic clone

Sox100B^del1

adult midgut epithelium | adult stage | somatic clone, with Scer\GAL4^Act.PU

adult posterior midgut | somatic clone

Sox100B^d1

adult posterior midgut | somatic clone, with Scer\GAL4^Tub.PU

Sox100B^GLV21021

axoneme, with Scer\GAL4^{CG13917-BG01278}

Sox100B^GLV21021

enteroblast | adult stage | decreased number

Sox100B^del1

enteroblast | adult stage | decreased number | somatic clone, with Scer\GAL4^Act.PU

Sox100B^GD4588

enteroblast | adult stage | increased number, with Scer\GAL4^Su(H).GBE

Sox100B^GD4588

intestinal stem cell | adult stage | decreased number

Sox100B^del1

intestinal stem cell | adult stage | decreased number | somatic clone, with Scer\GAL4^Act.PU

ovariole | adult stage, with Scer\GAL4^GMR42B09

Sox100B^HMC04723

ovary | adult stage, with Scer\GAL4^GMR42B09

Sox100B^HMC04723

sperm flagellum | pupal stage, with Scer\GAL4^{CG13917-BG01278}

Sox100B^GLV21021

wing | female limited, with Scer\GAL4^Bx-MS1096

Sox100B^{UAS.ORF.GW.Tag:HA}

wing | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox100B^{UAS.ORF.GW.Tag:HA}

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (39)

Hsap\SOX8

8 of 14

Yes

Hsap\SOX9

8 of 14

Yes

Hsap\SOX10

8 of 14

Yes

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (18)

Rnor\Sox8

7 of 14

Yes

Rnor\Sox9

7 of 14

Yes

Rnor\Sox10

7 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

Yes

Rnor\Tcf7l1

1 of 14

Rnor\Tcf7

1 of 14

Mus musculus (laboratory mouse) (27)

Mmus\Sox9

8 of 14

Yes

Mmus\Sox10

8 of 14

Yes

Mmus\Sox8

7 of 14

Yes

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (36)

Xtro\sox8

7 of 13

Yes

Xtro\sox9

7 of 13

Yes

Xtro\sox10

7 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (33)

Drer\sox8b

8 of 14

Yes

Drer\sox9a

8 of 14

Yes

Drer\sox10

8 of 14

Yes

Drer\sox8a

7 of 14

Yes

Drer\sox9b

7 of 14

Yes

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (12)

Cele\sox-4

4 of 14

Yes

3 of 14

3 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP000922

7 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (10)

Atha\3xHMG-box1

2 of 13

Yes

Atha\3xHMG-box2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (4)

Scer\ROX1

6 of 13

Yes

Scer\ABF2

1 of 13

Scer\NHP6A

1 of 13

Scer\NHP6B

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\ste11

5 of 12

Yes

Spom\matmc_1

4 of 12

Spom\matmc_2

4 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sox100B. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (17)

6 of 13

5 of 13

5 of 13

5 of 13

5 of 13

4 of 13

Sox102F

3 of 13

bbx

1 of 13

cic

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

pan

1 of 13

Ssrp

1 of 13

tHMG1

1 of 13

tHMG2

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 6 )

Human Ortholog

Disease

Evidence

References

SOX9; SRY-box transcription factor 9

model of 46,XX sex reversal 2

IEA

(FlyBase, 2019-)

model of 46,XY sex reversal 10

IEA

(FlyBase, 2019-)

model of campomelic dysplasia

IEA

(FlyBase, 2019-)

SOX10; SRY-box transcription factor 10

model of PCWH syndrome

IEA

(FlyBase, 2019-)

model of Waardenburg syndrome type 4C

IEA

(FlyBase, 2019-)

model of Waardenburg syndrome type 2E

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SOX8; SRY-box transcription factor 8

8 of 14

605923

SOX9; SRY-box transcription factor 9

8 of 14

608160

SOX10; SRY-box transcription factor 10

8 of 14

602229

SOX12; SRY-box transcription factor 12

4 of 14

601947

SOX15; SRY-box transcription factor 15

4 of 14

601297

SOX1; SRY-box transcription factor 1

3 of 14

602148

SOX2; SRY-box transcription factor 2

3 of 14

184429

MICROPHTHALMIA, SYNDROMIC 3; MCOPS3

syndromic microphthalmia 3

SOX3; SRY-box transcription factor 3

3 of 14

313430

X-linked panhypopituitarism

SOX4; SRY-box transcription factor 4

3 of 14

184430

INTELLECTUAL DEVELOPMENTAL DISORDER WITH SPEECH DELAY AND DYSMORPHIC FACIES; IDDSDF

Coffin-Siris syndrome 10

SOX7; SRY-box transcription factor 7

3 of 14

612202

SOX11; SRY-box transcription factor 11

3 of 14

600898

INTELLECTUAL DEVELOPMENTAL DISORDER WITH MICROCEPHALY AND WITH OR WITHOUT OCULAR MALFORMATIONS OR HYPOGONADOTROPIC HYPOGONADISM; IDDMOH

Coffin-Siris syndrome 9

SOX13; SRY-box transcription factor 13

3 of 14

604748

SOX14; SRY-box transcription factor 14

3 of 14

604747

SOX17; SRY-box transcription factor 17

3 of 14

610928

vesicoureteral reflux

SOX18; SRY-box transcription factor 18

3 of 14

601618

SOX21; SRY-box transcription factor 21

3 of 14

604974

SRY; sex determining region Y

3 of 14

480000

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Jin et al., 2020)

suppressible

(Jin et al., 2020)

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

suppressible

(Jin et al., 2020)

suppressible

(Jin et al., 2020)

suppressible

(Jin et al., 2020)

suppressible

(Jin et al., 2020)

suppressible

(Meng et al., 2020)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

69448

DroID - A comprehensive database of gene and protein interactions.

FBgn0024288

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-102

Cytogenetic map

100B2-100B2

Sequence location

3R:31,065,253..31,083,407 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

100B2-100B2

Limits computationally determined from genome sequence between P{PZ}Aph-4⁰⁷⁰²⁸&P{PZ}dco^rK215 and P{PZ}l(3)rM731^rM731

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

100B-100B

(Russell, 1999.11.17)

100B-100B

(determined by in situ hybridisation)

(Russell, 1998.3.16)

Experimentally Determined Recombination Data

Location

3-102

(FlyBase, 2016)

3-99.0

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (17)

Genomic Clones (29)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (2)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0024288

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0024288

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Jin et al., 2020)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: Sequence similarity to human SOX9.

(Loh et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Sox100B CG12098

(Crane-Robinson, 2000.5.9, Russell, 2000.4.27, FlyBase, 1996-)

Source for merge of: Sox100B CG15552

(FlyBase Genome Annotators, 2002-2003)

Source for merge of: Sox100B CG18674

(FlyBase, 1996-)

Additional comments

Annotations CG15552 and CG12098 merged as CG15552 in release 3 of the genome annotation.

(FlyBase Genome Annotators, 2002-2003)

Source for merge of Sox100B CG12098 was sequence comparison ( date:000607 ).

(FlyBase, 1996-)

Source for merge of Sox100B CG18674 was sequence comparison ( date:001216 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (12)

Reported As

Symbol Synonym

CG12098

(Crane-Robinson, 2000.5.7, Crane-Robinson, 2000.5.9, Russell, 2000.4.27)

CG15552

(Ni et al., 2011.7.19, Ni et al., 2010.12.1)

CG18674

CT6009

(Ceriani et al., 2002)

SOX100B

(Ågren et al., 2020, Whitworth et al., 2012, Weyers et al., 2011, DeFalco et al., 2008, Lemos et al., 2008, Hempel and Oliver, 2007, Hempel and Oliver, 2006, Le Bras and Van Doren, 2006, Bowles et al., 2000)

SOXE

(Bowles et al., 2000)

Sox100

(Sessa and Bianchi, 2007)

Sox9

(Van Doren et al., 2002)

SoxB

(Loh et al., 1998, Russell, 1998.3.16)

dSox9

(Lan et al., 2018)

sox100b

(Sutton et al., 2024)

Name Synonyms

SOX100B

(Hempel and Oliver, 2007)

Sox100B

(Cossais et al., 2010)

Secondary FlyBase IDs

FBgn0039814
FBgn0039815
FBgn0040626

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 35 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

45039

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

AJ251580

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VA17

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VA17

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0024288

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

45039/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0024288

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0024288

FlyMine - An integrated database for Drosophila genomics

FBgn0024288

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG15552

MARRVEL_MODEL - MARRVEL (model organism gene)

45039

Linkouts

BioGRID - A database of protein and genetic interactions.

69448

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0024288

DroID - A comprehensive database of gene and protein interactions.

FBgn0024288

DRSC - Results frm RNAi screens

FBgn0024288

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sox100B_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0024288

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0024288

Flygut - An atlas of the Drosophila adult midgut

FBgn0024288

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0024288

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC032549

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (105)

The following external sites may use different assemblies or annotations than FlyBase.

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