FlyBase Gene Report: Dmel\Sox102F

General Information

Symbol

Dmel\Sox102F

Species

D. melanogaster

Name

Sox102F

Annotation Symbol

CG11153

Feature Type

protein_coding_gene

FlyBase ID

FBgn0039938

Gene Model Status

Current

Stock Availability

33 publicly available

Gene Summary

Sox102F (Sox102F) encodes a transcription factor in the Sox gene family that regulates the Wnt signaling pathway. Its roles include heart development and cardiac function, and wing vein development and patterning. [Date last reviewed: 2019-03-14] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

SoxD

Key Links

Genomic Location

Cytogenetic map

102E1-102E3

Sequence location

4:800,436..834,393 [-]

Recombination map

4-0

RefSeq locus

NC_004353 REGION:800436..834393

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

NCBI

UCSC

Ensembl

Function

Gene Ontology (GO) Annotations (6 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription factor activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN002909527

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN002909527

(GO Reference Genome Project, 2011-)

Biological Process (3 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

involved_in positive regulation of heart contraction

inferred from mutant phenotype

(Li et al., 2013)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell fate commitment

inferred from biological aspect of ancestor with PANTHER:PTN000030844

(GO Reference Genome Project, 2011-)

involved_in regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN002909527

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN002909527

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -: The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).

Summary (Interactive Fly)

(common alternative name: SoxD) HMG-domain protein - SOX-domain transcription factor - optic lobe - olfactory perception - neuromuscular junction - axon guidance, adult courtship behavior - wing - heart

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sox102F for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q59DN5)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.47

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sox102F-RA

FBtr0089252

NM_166792

2767

580

Sox102F-RB

FBtr0100600

NM_001014695

3804

618

Sox102F-RC

FBtr0334488

NM_001272144

2840

580

Sox102F-RD

FBtr0334489

NM_001272145

2902

580

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sox102F-PA

FBpp0088312

62.8

580

7.84

FBpp0100057

67.2

618

7.72

FBpp0306556

62.8

580

7.84

FBpp0306557

62.8

580

7.84

Q9V480

NP_001259074

AGB96564

Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

580 aa isoforms: Sox102F-PA, Sox102F-PC, Sox102F-PD

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sox102F using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.92

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

mushroom body primordium

Comment: reported as embryonic central brain mushroom body

(Fisher et al., 2012)

larval ventral nerve cord

(Fisher et al., 2012)

embryonic stage 16 -- 17

neuron of larval brain

(Cremazy et al., 2001)

neuron of larval ventral nerve cord

(Cremazy et al., 2001)

third instar larval stage

larval brain | restricted

(Cremazy et al., 2001)

Additional Descriptive Data

Sox102F is first expressed at embryonic stages 17/17, in the brain and in a subset of neuronal cells in the ventral nerve cord. In third instar larvae, Sox102F is expressed at the interface of the central brain and optic lobes. Sox102F transcript is undetectable in imaginal discs.

(Cremazy et al., 2001)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

third instar larval stage

T4 neuron

(Schilling et al., 2019)

T5 neuron

(Schilling et al., 2019)

adult stage

T4 neuron

(Schilling et al., 2019)

T5 neuron

(Schilling et al., 2019)

Additional Descriptive Data

Sox102F is expressed in all T4/T5 neuron subtypes, but not in their progenitors or in C/T neurons.

(Schilling et al., 2019)

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sox102F in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sox102F

View exonic expression by tissue for Dmel\Sox102F

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039938

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43844/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039938

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039938

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039938

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11153

Flygut - An atlas of the Drosophila adult midgut

FBgn0039938

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\Sox102F

Stages(s) 11-12
Stages(s) 13-16

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 7 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sox102F

Transgenic constructs containing regulatory region of Sox102F

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(4)C3

(Podemski et al., 2004)

Inferred from location ( 6 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^Bx-MS1096

Sox102F^{UAS.ORF.GW.Tag:HA}

lethal - all die during embryonic stage, with Scer\GAL4^da.PU

Sox102F^HJF

lethal - all die during embryonic stage, with Scer\GAL4^ey.PU

Sox102F^HJF

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Sox102F^GD4589

viable, with Scer\GAL4^Mef2.PR

Sox102F^GD4589

viable, with Scer\GAL4^pnr-MD237

Sox102F^GD4589

viable, with Scer\GAL4^tin.CΔ4

Sox102F^GD4589

Sterility

Allele

female fertile

female fertile (with Df(4)ED6382)

female fertile (with Df(4)O2)

Other Phenotypes

Allele

abnormal courtship behavior, with Scer\GAL4^insc.PU

Sox102F^JF02118

abnormal locomotor behavior | adult stage, with Scer\GAL4^Toll-6-D42

Sox102F^JF02118

abnormal locomotor behavior | third instar larval stage, with Scer\GAL4^Toll-6-D42

Sox102F^JF02118

abnormal neuroanatomy | adult stage, with Scer\GAL4^insc.PU

Sox102F^JF02118

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^ppk.PU

Sox102F^JF02118

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^Toll-6-D42

Sox102F^JF02118

abnormal smell perception | third instar larval stage, with Scer\GAL4^Tab2-201Y

Sox102F^JF02118

visible, with Scer\GAL4^Bx-MS1096-KE

Sox102F^HJF

visible, with Scer\GAL4^ey.PH

Sox102F^HJF

visible, with Scer\GAL4^GMR.PF

Sox102F^HJF

visible, with Scer\GAL4^sd-SG29.1

Sox102F^JF02118

Phenotype manifest in

Allele

adult brain, with Scer\GAL4^insc.PU

Sox102F^JF02118

adult heart, with Scer\GAL4^how-24B

Sox102F^JF02118

dendritic arborizing neuron | third instar larval stage, with Scer\GAL4^ppk.PU

Sox102F^JF02118

dendritic tree | third instar larval stage, with Scer\GAL4^ppk.PU

Sox102F^JF02118

eye, with Scer\GAL4^ey.PH

Sox102F^HJF

eye, with Scer\GAL4^GMR.PF

Sox102F^HJF

microchaeta, with Scer\GAL4^pnr.PU

Sox102F^JF02118

myofibril, with Scer\GAL4^how-24B

Sox102F^JF02118

NMJ bouton | third instar larval stage, with Scer\GAL4^Toll-6-D42

Sox102F^JF02118

wing, with Scer\GAL4^Bx-MS1096-KE

Sox102F^HJF

wing, with Scer\GAL4^sd-SG29.1

Sox102F^JF02118

wing vein L2, with Scer\GAL4^sd-SG29.1

Sox102F^JF02118

wing vein L3, with Scer\GAL4^sd-SG29.1

Sox102F^JF02118

wing vein L3 | ectopic, with Scer\GAL4^sd-SG29.1

Sox102F^JF02118

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (40)

Hsap\SOX5

9 of 14

Yes

Hsap\SOX6

9 of 14

Yes

Hsap\SOX13

8 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (15)

Rnor\Sox5

9 of 14

Yes

Rnor\Sox6

9 of 14

Yes

Rnor\Sox13

7 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (25)

Mmus\Sox5

9 of 14

Yes

Mmus\Sox6

9 of 14

Yes

Mmus\Sox13

8 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (35)

Xtro\sox5

6 of 13

Yes

Xtro\sox6

6 of 13

Yes

Xtro\sox13

6 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\LOC101734060

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (32)

Drer\sox5

8 of 14

Yes

Drer\sox6

8 of 14

Yes

Drer\sox13

7 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\egl-13

5 of 14

Yes

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (17)

Agam\AgaP_AGAP000066

4 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (10)

Atha\3xHMG-box1

2 of 13

Yes

Atha\3xHMG-box2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\ROX1

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\ste11

2 of 12

Yes

Spom\matmc_1

1 of 12

Spom\matmc_2

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sox102F. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (17)

4 of 13

4 of 13

4 of 13

4 of 13

4 of 13

3 of 13

Sox100B

3 of 13

cic

2 of 13

pan

2 of 13

bbx

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Allele

Disease

Evidence

References

Sox102F^JF02118

model of heart disease

CEA

(Li et al., 2013)

model of Alzheimer's disease

CEA

(Li et al., 2017)

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SOX5; SRY-box transcription factor 5

9 of 14

604975

LAMB-SHAFFER SYNDROME; LAMSHF

SOX6; SRY-box transcription factor 6

9 of 14

607257

TOLCHIN-LE CAIGNEC SYNDROME; TOLCAS

SOX13; SRY-box transcription factor 13

8 of 14

604748

SOX3; SRY-box transcription factor 3

3 of 14

313430

X-linked panhypopituitarism

SOX4; SRY-box transcription factor 4

3 of 14

184430

INTELLECTUAL DEVELOPMENTAL DISORDER WITH SPEECH DELAY AND DYSMORPHIC FACIES; IDDSDF

Coffin-Siris syndrome 10

SOX7; SRY-box transcription factor 7

3 of 14

612202

SOX8; SRY-box transcription factor 8

3 of 14

605923

SOX9; SRY-box transcription factor 9

3 of 14

608160

SOX10; SRY-box transcription factor 10

3 of 14

602229

SOX11; SRY-box transcription factor 11

3 of 14

600898

INTELLECTUAL DEVELOPMENTAL DISORDER WITH MICROCEPHALY AND WITH OR WITHOUT OCULAR MALFORMATIONS OR HYPOGONADOTROPIC HYPOGONADISM; IDDMOH

Coffin-Siris syndrome 9

SOX12; SRY-box transcription factor 12

3 of 14

601947

SOX14; SRY-box transcription factor 14

3 of 14

604747

SOX15; SRY-box transcription factor 15

3 of 14

601297

SOX18; SRY-box transcription factor 18

3 of 14

601618

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sox102F - CtBP

two hybrid array

(Shokri et al., 2019)

Sox102F - Hr78

two hybrid array

(Shokri et al., 2019)

Sox102F - Irbp18

two hybrid array

(Shokri et al., 2019)

Sox102F - Rel

two hybrid array

(Shokri et al., 2019)

Sox102F - croc

two hybrid array

(Shokri et al., 2019)

Sox102F - drm

two hybrid array

(Shokri et al., 2019)

Sox102F - p53

two hybrid array

(Shokri et al., 2019)

Sox102F - pdm2

two hybrid array

(Shokri et al., 2019)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Rrp4

enhanceable

Sox102F

(Yang et al., 2020)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

68668

DroID - A comprehensive database of gene and protein interactions.

FBgn0039938

MIST (protein-protein) - An integrated Molecular Interaction Database

43844

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

4-0

Cytogenetic map

102E1-102E3

Sequence location

4:800,436..834,393 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

102E1-102E3

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

4-0

(FlyBase, 2016)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (33)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

50072

w¹¹¹⁸; P{GMR40A01-GAL4}attP2

50159

w¹¹¹⁸; P{GMR42E12-GAL4}attP2

50172

w¹¹¹⁸; P{GMR42H07-GAL4}attP2

600794

w¹¹¹⁸; P{R40A12-p65.AD}JK22C

54099

w¹¹¹⁸; P{GMR42H07-lexA}attP40

54792

w¹¹¹⁸; P{GMR41D02-lexA}attP40

69057

w¹¹¹⁸; P{R42E12-GAL4.DBD}attP2

600888

w¹¹¹⁸; P{R40A12-GAL4.DBD}attP2

54731

w¹¹¹⁸; P{GMR40A01-lexA}attP40/CyO

FlyORF

F001902

M{UAS-Sox102F.ORF.3xHA.GW}ZH-86Fb

VDRC

v330016

P{VSH330016}attP40

v19022

w¹¹¹⁸; P{GD4589}v19022

More stocks available...

Genomic Clones (19)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (23)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

LD16247

Other clones

FI18025

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0039938

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0039938

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Konstantinides et al., 2022, Schilling et al., 2019)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Source for identity of: Sox102F SoxD

(FlyBase, 1996-)

Source for identity of: Sox102F CG11153

(McKimmie et al., 2001, Overton, 2001.9.6)

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG11153

(Meadows, 2017.1.11, Hosono et al., 2015, Perkins et al., 2009, Perkins et al., 2009.3.31, Wang et al., 2002, Cremazy et al., 2001)

SOX102D

(Bowles et al., 2000)

SOX102F

(Yang et al., 2020)

SOXD

(Bowles et al., 2000)

Sox D

(Cremazy et al., 2001)

Sox102D

Sox102F

Sox102f

(McLamb et al., 2025)

SoxD

(Contreras et al., 2018)

sox102F

(Park et al., 2023)

Name Synonyms

Sox102F

Secondary FlyBase IDs

FBgn0043567

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 64 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

43844

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q59DN5

UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q59DN5

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0039938

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

43844/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0039938

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0039938

FlyMine - An integrated database for Drosophila genomics

FBgn0039938

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG11153

MARRVEL_MODEL - MARRVEL (model organism gene)

43844

Linkouts

BioGRID - A database of protein and genetic interactions.

68668

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0039938

DroID - A comprehensive database of gene and protein interactions.

FBgn0039938

DRSC - Results frm RNAi screens

FBgn0039938

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0039938

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0039938

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG11153

Flygut - An atlas of the Drosophila adult midgut

FBgn0039938

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0039938

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC007419

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (protein-protein) - An integrated Molecular Interaction Database

43844

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

References (78)

The following external sites may use different assemblies or annotations than FlyBase.

-0.92

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