FlyBase Gene Report: Dmel\Sox15

General Information

Symbol

Dmel\Sox15

Species

D. melanogaster

Name

Sox box protein 15

Annotation Symbol

CG8404

Feature Type

protein_coding_gene

FlyBase ID

FBgn0005613

Gene Model Status

Current

Stock Availability

14 publicly available

Gene Summary

Sox box protein 15 (Sox15) encodes a transcription factor that regulates cell proliferation and cell death in the wing disc. [Date last reviewed: 2019-09-12] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
Interactive Fly

Also Known As

SoxE, SoxF

Key Links

Genomic Location

Cytogenetic map

50E4-50E4

Sequence location

2R:14,201,390..14,212,413 [-]

Recombination map

2-69

RefSeq locus

NT_033778 REGION:14201390..14212413

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (11 terms)

Molecular Function (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables DNA-binding transcription activator activity, RNA polymerase II-specific

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(GO Reference Genome Project, 2011-)

enables RNA polymerase II cis-regulatory region sequence-specific DNA binding

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(GO Reference Genome Project, 2011-)

Biological Process (8 terms)

Terms Based on Experimental Evidence (6 terms)

CV Term

Evidence

References

involved_in chaeta development

inferred from mutant phenotype

(Miller et al., 2009)

inferred from genetic interaction with FLYBASE:Su(H); FB:FBgn0004837

(Miller et al., 2009)

involved_in negative regulation of apoptotic process

inferred from mutant phenotype

(Dichtel-Danjoy et al., 2009)

involved_in negative regulation of cell population proliferation

inferred from mutant phenotype

(Dichtel-Danjoy et al., 2009)

involved_in negative regulation of DNA-templated transcription

inferred from mutant phenotype

(Dichtel-Danjoy et al., 2009)

involved_in negative regulation of transcription by RNA polymerase II

inferred from genetic interaction with FLYBASE:Su(H); FB:FBgn0004837

(Miller et al., 2009)

involved_in wing disc development

inferred from mutant phenotype

(Dichtel-Danjoy et al., 2009)

inferred from genetic interaction with FLYBASE:wg; FB:FBgn0284084

(Dichtel-Danjoy et al., 2009)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in cell differentiation

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(GO Reference Genome Project, 2011-)

involved_in positive regulation of transcription by RNA polymerase II

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(GO Reference Genome Project, 2011-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Miller et al., 2009)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000030384

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS

Protein Family (UniProt)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Sox box protein 15 (Sox15) encodes a transcription factor that regulates cell proliferation and cell death in the wing disc. [Date last reviewed: 2019-09-12]

Gene Group (FlyBase)

HIGH MOBILITY GROUP BOX TRANSCRIPTION FACTORS -: The High mobility group box (HMGB) transcription factors are sequence-specific DNA binding proteins that regulate transcription. The HMGB proteins have a characteristic L-shaped HMGB domain of about 80 amino acid residues, which binds the DNA minor groove and induce DNA bending. The HMGB domains are found in one or more copies and are involved in the regulation of DNA-dependent processes such as transcription, replication and chromatin remodeling. (Adapted from FBrf0194706, FBrf0108466, PMID:24086078 and PMID:23153957).

Summary (Interactive Fly)

HMG-domain protein - SOX-domain protein - under the control of the canonical wingless pathway such that wg and Sox15 regulate each other's transcription through a feedback loop that results in proliferation of wing hinge cells

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\Sox15 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry P40657)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Gene model reviewed during 5.50

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

Sox15-RA

FBtr0087576

NM_079015

3651

784

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

Sox15-PA

FBpp0086702

84.9

784

7.02

P40657

NP_523739

AAF58279

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

P40657

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Sox15 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sox15_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.41

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism

(Fisher et al., 2012)

embryonic stage 11 -- 12

antennal primordium

(Fisher et al., 2012)

dorsal sensory complex primordium

(Fisher et al., 2012)

posterior pharyngeal sense organ primordium

(Fisher et al., 2012)

labial sensory complex primordium

(Fisher et al., 2012)

labral sensory complex primordium

(Fisher et al., 2012)

maxillary sensory complex primordium

(Fisher et al., 2012)

ventral sensory complex anlage

(Fisher et al., 2012)

embryonic stage 12 -- 13

presumptive embryonic/larval peripheral nervous system

Comment: likely socket cells of external sense organs

(Cremazy et al., 2001)

embryonic stage 13 -- 16

dorsal sensory complex proper primordium

Comment: reported as dorsal/lateral sensory complexes

(Fisher et al., 2012)

embryonic head sensory system

(Fisher et al., 2012)

ventral sensory complex primordium

(Fisher et al., 2012)

third instar larval stage

wing hinge primordium

Comment: complementary to rn and wg

(Dichtel-Danjoy et al., 2009, Cremazy et al., 2001)

anterior-posterior compartment boundary of the leg disc | proximal

(Cremazy et al., 2001)

pupal stage P5(ii) -- pupal stage P6

macrochaeta

Comment: assayed at 17h, 21h, 30h APF

(Miller et al., 2009)

microchaeta

Comment: assayed at 17h, 21h, 30h APF

(Miller et al., 2009)

tormogen cell

Comment: assayed at 17h, 21h, 30h APF

(Miller et al., 2009)

Additional Descriptive Data

Sox15 transcripts are abundant in prospective hinge cells in late third instar wing discs. The Sox15 domain straddles the gap domain in the wing hinge defined by the nub and tsh domains. It is complementary to the wg and rn domains.

(Dichtel-Danjoy et al., 2009)

Sox15 is weakly detected in microchaetes and macrochaetes at 17 and 21 hours APF and more strongly in these same cells at 30 hours APF.

(Miller et al., 2009)

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

immunolocalization

Stage

Tissue/Position (including subcellular localization)

Reference

larval stage

tormogen cell

(Miller et al., 2009)

external sensory organ

(Miller et al., 2009)

larval peripheral nervous system

(Miller et al., 2009)

third instar larval stage

wing disc

(Miller et al., 2009)

wing hinge primordium

(Miller et al., 2009)

leg disc

(Miller et al., 2009)

haltere disc

Comment: presumptive hinge region

(Miller et al., 2009)

adult stage

tormogen cell

(Miller et al., 2009)

external sensory organ

(Miller et al., 2009)

adult peripheral nervous system

(Miller et al., 2009)

Additional Descriptive Data

Sox15 protein is expressed specifically in socket cells of external sensory organs in larval and adult PNS. It is present in imaginal discs of late third instar larvae. Sox15 localizes to the presumptive hinge region in wing and haltere discs, In leg discs the protein is found in discrete patches on opposite sides of the proximal leg primordium.

(Miller et al., 2009)

Marker for

Subcellular Localization

CV Term

Evidence

References

located_in nucleus

inferred from direct assay

(Miller et al., 2009)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Sox15 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Sox15

View exonic expression by tissue for Dmel\Sox15

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005613

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36575/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0005613

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0005613

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0005613

Flygut - An atlas of the Drosophila adult midgut

FBgn0005613

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 8 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Sox15

Transgenic constructs containing regulatory region of Sox15

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(2R)BSC134

(Christensen and Cook, 2006.3.8)

Df(2R)BSC401

(Christensen et al., 2007.10.29)

Df(2R)Exel7130

(Dichtel-Danjoy et al., 2009, Ryder, 2004.4.26)

Inferred from location ( 4 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal | male limited, with Scer\GAL4^Bx-MS1096

Sox15^{UAS.ORF.GW.Tag:HA}

lethal | male limited | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox15^{UAS.ORF.GW.Tag:HA}

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Sox15^GD4417

partially lethal - majority die | recessive

viable, with Scer\GAL4^Mef2.PR

Sox15^GD4417

viable, with Scer\GAL4^tin.CΔ4

Sox15^GD4417

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage

Sox15^4AA

abnormal neurophysiology | adult stage

Sox15^4AA

abnormal size | recessive | third instar larval stage

Sox15^KG09145

hyperplasia | third instar larval stage

Sox15^KG09145

increased cell death | recessive | third instar larval stage

Sox15^KG09145

increased occurrence of cell division | third instar larval stage

Sox15^KG09145

short lived, with Scer\GAL4^Mef2.PR

Sox15^GD4417

short lived | recessive

Sox15²⁶

some die during pupal stage, with Scer\GAL4^pnr-MD237

Sox15^GD4417

visible

Sox15^4AA

visible, with Scer\GAL4^Bx-MS1096

Sox15^GD4417

visible, with Scer\GAL4^pnr-MD237

Sox15^GD4417

visible | female limited, with Scer\GAL4^Bx-MS1096

Sox15^{UAS.ORF.GW.Tag:HA}

visible | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox15^{UAS.ORF.GW.Tag:HA}

Phenotype manifest in

Allele

alar lobe

Sox15^KG09145

eo dendrite

Sox15^4AA

leg joint

Sox15^4AA

mechanosensory chaeta

Sox15^4AA

tormogen cell

Sox15^4AA

trichogen cell, with Scer\GAL4^pnr-MD237

Sox15^GD4417

wing, with Scer\GAL4^Bx-MS1096

Sox15^GD4417

wing | female limited, with Scer\GAL4^Bx-MS1096

Sox15^{UAS.ORF.GW.Tag:HA}

wing | female limited | cold sensitive, with Scer\GAL4^Bx-MS1096

Sox15^{UAS.ORF.GW.Tag:HA}

wing blade

Sox15²⁶

wing hinge

wing hinge primordium

Sox15^KG09145

wing sclerite

Sox15^KG09145

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (41)

Hsap\SOX7

6 of 14

Yes

Hsap\SOX18

6 of 14

Yes

Hsap\SOX12

5 of 14

Hsap\SOX15

5 of 14

Yes

Hsap\SOX17

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (21)

Rnor\Sox7

6 of 14

Yes

Rnor\Sox17

6 of 14

Yes

Rnor\Sox18

6 of 14

Yes

5 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (30)

Mmus\Sox7

6 of 14

Yes

Mmus\Sox17

6 of 14

Yes

Mmus\Sox18

6 of 14

Yes

Mmus\Sox12

5 of 14

Mmus\Sox15

5 of 14

Yes

Mmus\Sry

5 of 14

Yes

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

Yes

Mmus\Sox6

2 of 14

Mmus\Sox16

2 of 14

Yes

Mmus\Sox19

2 of 14

Yes

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (35)

Xtro\sox7

5 of 13

Yes

Xtro\sox17a

5 of 13

Yes

Xtro\sox17b.1

5 of 13

Yes

Xtro\sox17b.2

5 of 13

Yes

Xtro\sox18

5 of 13

Yes

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

3 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (37)

Drer\sox18

6 of 14

Yes

Drer\sox7

5 of 14

Yes

Drer\sox17

5 of 14

Yes

5 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

4 of 14

Yes

3 of 14

3 of 14

3 of 14

3 of 14

3 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (10)

Cele\sem-2

4 of 14

Yes

Cele\sox-3

4 of 14

Yes

Cele\sox-4

4 of 14

Yes

3 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Anopheles gambiae (African malaria mosquito) (20)

Agam\AgaP_AGAP012033

4 of 12

Yes

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

3 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (10)

Atha\3xHMG-box1

2 of 13

Yes

Atha\3xHMG-box2

2 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (5)

Scer\ROX1

3 of 13

Yes

2 of 13

1 of 13

1 of 13

1 of 13

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\matmc_1

5 of 12

Yes

Spom\matmc_2

5 of 12

Yes

Spom\ste11

4 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:Sox15. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (17)

Sox21b

7 of 13

6 of 13

6 of 13

6 of 13

6 of 13

5 of 13

4 of 13

cic

2 of 13

pan

2 of 13

bbx

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 5 )

Human Ortholog

Disease

Evidence

References

SOX18; SRY-box transcription factor 18

model of hypotrichosis-lymphedema-telangiectasia syndrome

IEA

(FlyBase, 2019-)

model of hypotrichosis-lymphedema-telangiectasia-renal defect syndrome

IEA

(FlyBase, 2019-)

SOX17; SRY-box transcription factor 17

model of vesicoureteral reflux

IEA

(FlyBase, 2019-)

SRY; sex determining region Y

model of 46,XY sex reversal 1

IEA

(FlyBase, 2019-)

model of 46,XX sex reversal 1

IEA

(FlyBase, 2019-)

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

SOX7; SRY-box transcription factor 7

6 of 14

612202

SOX18; SRY-box transcription factor 18

6 of 14

601618

SOX12; SRY-box transcription factor 12

5 of 14

601947

SOX15; SRY-box transcription factor 15

5 of 14

601297

SOX17; SRY-box transcription factor 17

5 of 14

610928

vesicoureteral reflux

SOX1; SRY-box transcription factor 1

4 of 14

602148

SOX2; SRY-box transcription factor 2

4 of 14

184429

MICROPHTHALMIA, SYNDROMIC 3; MCOPS3

syndromic microphthalmia 3

SOX3; SRY-box transcription factor 3

4 of 14

313430

X-linked panhypopituitarism

SOX4; SRY-box transcription factor 4

4 of 14

184430

INTELLECTUAL DEVELOPMENTAL DISORDER WITH SPEECH DELAY AND DYSMORPHIC FACIES; IDDSDF

Coffin-Siris syndrome 10

SOX11; SRY-box transcription factor 11

4 of 14

600898

INTELLECTUAL DEVELOPMENTAL DISORDER WITH MICROCEPHALY AND WITH OR WITHOUT OCULAR MALFORMATIONS OR HYPOGONADOTROPIC HYPOGONADISM; IDDMOH

Coffin-Siris syndrome 9

SOX14; SRY-box transcription factor 14

4 of 14

604747

SOX21; SRY-box transcription factor 21

4 of 14

604974

SRY; sex determining region Y

4 of 14

480000

SOX8; SRY-box transcription factor 8

3 of 14

605923

SOX9; SRY-box transcription factor 9

3 of 14

608160

SOX10; SRY-box transcription factor 10

3 of 14

602229

SOX13; SRY-box transcription factor 13

3 of 14

604748

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Sox15 - abd-A

bimolecular fluorescence complementation, fluorescence microscopy

(Bischof et al., 2018)

Summary of Genetic Interactions

Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

enhanceable

Sox15

(Dichtel-Danjoy et al., 2009)

External Data

Linkouts

BioGRID - A database of protein and genetic interactions.

62325

DroID - A comprehensive database of gene and protein interactions.

FBgn0005613

MIST (genetic) - An integrated Molecular Interaction Database

36575

MIST (protein-protein) - An integrated Molecular Interaction Database

36575

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

FlyBase

External Links

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

Class of Gene

nuclear_gene

protein_coding_gene

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-69

Cytogenetic map

50E4-50E4

Sequence location

2R:14,201,390..14,212,413 [-]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

50E4-50E4

Limits computationally determined from genome sequence between P{lacW}mam^k05821 and P{lacW}l(2)s3475^s3475&P{lacW}Hsc70-5^k04907

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

50D-50E

(determined by in situ hybridisation)

(Russell, 1998.3.16)

Experimentally Determined Recombination Data

Location

2-69

(FlyBase, 2016)

2-74.5

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (14)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

93036

w^*; P{Sox15-GFP.7.5}11

66396

w¹¹¹⁸; PBac{Sox15-GFP.FPTB}VK00033

93035

y¹ w^*; Sox15^4AA/CyO

14980

y¹; P{SUPor-P}Sox15^KG09145/CyO; ry⁵⁰⁶

80751

y¹ sc^* v¹ sev²¹; P{TOE.GS02128}attP40

606547

y¹ w^*; TI{CRIMIC.TG4.2}Sox15^{CR01610-TG4.2}/SM6a

FlyORF

F004823

M{UAS-Sox15.ORF-VN}ZH-86Fb

F001698

M{UAS-Sox15.ORF.3xHA.GW}ZH-86Fb

VDRC

v330360

P{VSH330360}attP40

v45482

w¹¹¹⁸; P{GD4417}v45482

v318020

PBac{fTRG00045.sfGFP-TVPTBF}VK00033

v342419

P{hsFLP}1, y¹ w¹¹¹⁸; P{HD_CFD01138}attP40/CyO-GFP

More stocks available...

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (14)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

IP09065

Other clones

FI01112

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0005613

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0005613

Antibody Information

Laboratory Generated Antibodies

polyclonal

(Miller et al., 2009)

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: Sequence similarity to human SOX9.

(Loh et al., 1998)

Relationship to Other Genes

Source for database merge of

Source for merge of: Sox15 CG13945

(FlyBase, 1996-)

Source for merge of: Sox50E Sox15

(FlyBase, 1996-)

Additional comments

Release 1 annotation CG13945 corresponds to part of the release 3.2 annotation for Sox15 (CG8404).

(FlyBase, 1996-)

Source for merge of Sox50E Sox15 was sequence comparison ( date:000606 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (14)

Reported As

Symbol Synonym

CG13945

CG8404

(Meadows, 2017.1.11, Ni et al., 2010.12.1, Dichtel-Danjoy et al., 2009, Klebes et al., 2005, Cremazy et al., 2001)

DSox-15

(Denny et al., 1992)

Dsox-15

(Denny, 1992.4.23)

SOX15

(Bowles et al., 2000)

SOX50E

(Bowles et al., 2000)

SOXF

(Bowles et al., 2000)

Sox F

(Cremazy et al., 2001)

Sox50E

SoxE

(Loh et al., 1998, Russell, 1998.3.16)

SoxF

(Janssen et al., 2018, Dichtel-Danjoy et al., 2009)

sox15

(Bischof et al., 2018)

Name Synonyms

Sox box protein 15

Secondary FlyBase IDs

FBgn0024287
FBgn0040750

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 36 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36575

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

P40657

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

P40657

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

P40657

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0005613

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36575/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0005613

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0005613

FlyMine - An integrated database for Drosophila genomics

FBgn0005613

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG8404

MARRVEL_MODEL - MARRVEL (model organism gene)

36575

Linkouts

BioGRID - A database of protein and genetic interactions.

62325

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0005613

DroID - A comprehensive database of gene and protein interactions.

FBgn0005613

DRSC - Results frm RNAi screens

FBgn0005613

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

Sox15_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0005613

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0005613

Flygut - An atlas of the Drosophila adult midgut

FBgn0005613

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0005613

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC033720

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

MIST (genetic) - An integrated Molecular Interaction Database

36575

MIST (protein-protein) - An integrated Molecular Interaction Database

36575

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Deactivation of the beta-catenin transactivating complex

References (68)

The following external sites may use different assemblies or annotations than FlyBase.

-0.41

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