FlyBase Allele Report: Dmel\Xrp1[GD9476]

General Information

Symbol

Dmel\Xrp1^GD9476

Species

D. melanogaster

Name

FlyBase ID

FBal0201971

Feature type

allele

Associated gene

Dmel\Xrp1

Associated Insertion(s)

Carried in Construct

P{GD9476}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD9476}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD9476

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 6

modeled by caz²

(Mallik et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Phenotype Manifest In

Detailed Description

Statement

Reference

Adults expressing Xrp1^GD9476 under the control of Scer\GAL4^elav-C155 do not show any obvious change in lifespan, as compared to controls.

(Mallik et al., 2018)

Adults expressing Xrp1^GD9476 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9476

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Scer\GAL4^elav-C155/Xrp1^GD9476 is a suppressor of lethal - all die during pupal stage phenotype of caz²

(Mallik et al., 2018)

NOT Suppressor of

Statement

Reference

Xrp1^GD9476/Scer\GAL4^repo.PU is a non-suppressor of lethal - all die during pupal stage phenotype of caz²

(Mallik et al., 2018)

Other

Statement

Reference

Scer\GAL4^elav-C155, Xrp1^GD9476, caz² has short lived phenotype

(Mallik et al., 2018)

Scer\GAL4^elav-C155, Xrp1^GD9476, caz^KO has short lived phenotype

(Mallik et al., 2018)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

caz² males rescued to adulthood by the expression of Xrp1^GD9476 under the control of Scer\GAL4^elav-C155 are short lived.

(Mallik et al., 2018)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v33010

w¹¹¹⁸; P{GD9476}v33010

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

9476

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

CG17836^GD9476

Xrp1^GD9476

Name Synonyms

Secondary FlyBase IDs

References (7)

Report Sections

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