FB2026_02 , released June 18, 2026
Allele: Dmel\Xrp1KO
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General Information
Symbol
Dmel\Xrp1KO
Species
D. melanogaster
Name
FlyBase ID
FBal0344645
Feature type
allele
Associated gene
Dmel\Xrp1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

amorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

amorphic allele - molecular evidence

(Mallik et al., 2018)
Mutagen
gene targeting by homologous recombination
(Mallik et al., 2018)
Progenitor genotype
Mi{MIC}Xrp1MI07118
(Mallik et al., 2018)
Cytology
Description

Precise deletion of the Xrp1 coding sequence. Generated by replacing the RMCE cassette in Mi{MIC}Xrp1MI07118 with a targeting construct, followed by two rounds of homologous recombination in which the targeting construct acts as the donor.

(Mallik et al., 2018)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
deletion
3R:18,914,957..18,926,510 [+]
Comment:

Deletion of Xrp1 created by homologous recombination. Position of deletion endpoints on reference sequence determined from reported primer sequences.

(Mallik et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  amyotrophic lateral sclerosis type 6
      modeled by caz2
      (Mallik et al., 2018)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      cazKO mutant larvae do not show any obvious defects in larval crawling ability (i.e. speed), as compared to controls.

      (Mallik et al., 2018)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      Xrp1KO/Xrp1[+] is a suppressor of lethal - all die during pupal stage phenotype of caz2

      (Mallik et al., 2018)

      Xrp1KO/Xrp1[+] is a suppressor of lethal - all die during pupal stage phenotype of cazKO

      (Mallik et al., 2018)

      Xrp1KO/Xrp1[+] is a suppressor of abnormal locomotor behavior | larval stage phenotype of cazKO

      (Mallik et al., 2018)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Xrp1KO
      (Catinozzi et al., 2020, Mallik et al., 2018)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)