FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term transcription coregulator activity ID (Ontology) GO:0003712 (Gene Ontology)
Definition A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.[ PubMed:10213677 PubMed:16858867 PubMed:24203923 PubMed:25957681 ]
Also Known As "transcription cofactor activity" ; "transcription coreceptor activity" ; "transcriptional co-regulator"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_CELLULAR_COMPONENT
Genes (FBgn)GO_MOLECULAR_FUNCTION
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Relevant FlyBase reports
 Gene Groups Genes
 transcription coregulator activity (all annotations which use CV term, excluding "NOT" statements)
     contributes_to | transcription coregulator activity       --
     enables | transcription coregulator activity       --
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  molecular_function
   |__transcription regulator activity
       |__transcription coregulator activity  202 rec.
           |__transcription coactivator activity 92 rec.
           |__transcription corepressor activity 61 rec.
               |__sigma factor antagonist activity
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Synonyms
  • "nuclear receptor coreceptor activity" NARROW
    "RNA polymerase II transcriptional cofactor activity" RELATED
    "transcription cofactor activity" EXACT
    "transcription coreceptor activity" EXACT
    "transcriptional co-regulator" EXACT
Secondary IDs
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Reactome:R-HSA-5340251 "NR1H4:DCA,CDCA,LCHA binds RXRA and NCOA1,2"