FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cazFRT
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General Information
Symbol
Dmel\cazFRT
Species
D. melanogaster
Name
FlyBase ID
FBal0323136
Feature type
allele
Associated gene
Dmel\caz
Associated Insertion(s)
TI{TI}cazFRT
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
phiC31 integrase
(Frickenhaus et al., 2015)
Progenitor genotype
cazKO
(Frickenhaus et al., 2015)
Associated Insertion(s)
TI{TI}cazFRT
Cytology
Description

Contains wild-type caz genomic sequence, with FRT sites flanking the sequence encoding exons 2 through 7 (generated by replacing the attP RMCE cassette in cazKO).

(Frickenhaus et al., 2015)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  amyotrophic lateral sclerosis type 6
      CEA
      (Frickenhaus et al., 2015)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Selective pan-neuronal removal of caz by expressing Scer\FLP1Scer\UAS.cDa under the control of Scer\GAL4elav-C155 in a cazFRT background results in motor defects, a majority exhibiting P-stage lethality attributable to the inability of adult flies to eclose from the pupal case, with a subset of adult escapers that have significantly reduced lifespan, as compared to controls.

      Selective adult pan-neuronal removal of caz by expressing Scer\FLP1Scer\UAS.cDa under the control of Scer\GAL4elav-C155 in a cazFRT background (in combination with a Gal80[ts] transgene to restrict expression to the adult stage) does not result in a climbing defect at 4 weeks of age, and no significant change in life span, as compared to controls.

      (Frickenhaus et al., 2015)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      cazFRT
      (Catinozzi et al., 2020, Frickenhaus et al., 2015)
      Name Synonyms
      Secondary FlyBase IDs
        References (2)