FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cazP398L.UAS.cUa
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General Information
Symbol
Dmel\cazP398L.UAS.cUa
Species
D. melanogaster
Name
UAS construct a of Unknown
FlyBase ID
FBal0349188
Feature type
allele
Associated gene
Dmel\caz
Associated Insertion(s)
Carried in Construct
P{UAS-caz.P398L.U}
Key Links
Genomic Maps

Transgenic product class
missense_variant
(FlyBase Curators, 2025-)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(FlyBase Curators, 2025-)
Mutagen
in vitro construct
(FlyBase Curators, 2025-)
Progenitor genotype
Carried in construct
P{UAS-caz.P398L.U}
Cytology
Description

UAS regulatory sequences drive expression of caz that carries the P398L mutation (equivalent to the disease-related P525L variant of the human Hsap\FUS ortholog).

(FlyBase Curators, 2025-)

FlyBase curator comment: this entry represents a transgenic construct where the particular construct used cannot be determined.

(FlyBase Curators, 2025-)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
caz
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:16,293,188..16,293,188 [+]
Nucleotide change:

C16293188T

Amino acid change:

P398L | caz-PB; P383L | caz-PC; P354L | caz-PD

Reported amino acid change:

P398L

Comment:

Analogous P525L mutation in human FUS implicated in amyotrophic lateral sclerosis 6; mutation carried on in vitro construct; site of nucleotide substitution in fly gene inferred by FlyBase curator based on reported amino acid change.

(Bogaert et al., 2018)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  amyotrophic lateral sclerosis type 6
      CEA
      (Bogaert et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      This allele represents a human variant implicated in disease.
      (FlyBase Curators, 2025-)
      FUS:p.Pro525Leu
      (FlyBase curators, 2019-)
      Variants Synonym(s)
      FUS:p.Pro521Leu
      FUS:p.Pro524Leu
      Associated human disease model(s)
      External database links
      ClinVar: FUS_280110
      Comments concerning this variant
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cazP398L.UAS.cUa
      Name Synonyms
      UAS construct a of Unknown
      Secondary FlyBase IDs
        References (3)