FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\cazTag:FLAG
Open Close
General Information
Symbol
Dmel\cazTag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0265757
Feature type
allele
Associated gene
Dmel\caz
Associated Insertion(s)
Carried in Construct
P{caz.FLAG}
Key Links
Transgenic product class
genomic_DNA
(Wang et al., 2011)
wild_type
(Wang et al., 2011)
Mutagen
Nature of the Allele
Transgenic product class
genomic_DNA
(Wang et al., 2011)
wild_type
(Wang et al., 2011)
Mutagen
in vitro construct
(Wang et al., 2011)
Progenitor genotype
Carried in construct
P{caz.FLAG}
Cytology
Description

6.4kb genomic fragment containing the caz promoter, full coding region and 3' sequences (but not the neighbouring CG32576 coding region). Three copies of Tag:FLAG sequence are inserted immediately after the caz start codon.

(Wang et al., 2011)
Allele components
Component
Use(s)
Regulatory region(s)
caz
Encoded product / tool
caz
Tagged with
Tag:FLAG
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      epitope tag
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      larval stage
      larval neuron
      (Wang et al., 2011)
      larval brain
      (Wang et al., 2011)
      larval muscle system
      (Wang et al., 2011)
      adult stage
      adult brain | restricted
      (Wang et al., 2011)
      Additional Information
      Statement
      Reference

      Tagged caz is detected in neurons in the adult brain and in larvae. It is also seen in other cell types including muscle and glia.

      (Wang et al., 2011)
       
      Marker for
      Reflects expression of
      caz
      (Wang et al., 2011)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  amyotrophic lateral sclerosis type 6
      CEA
      (Machamer et al., 2018)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      CG32576+t5.0/cazTag:FLAG rescues Df(1)383

      (Machamer et al., 2014)

      CG32576+t5.0/cazTag:FLAG rescues Df(1)383

      (Wang et al., 2011)
      Comments

      cazT:Zzzz\FLAG rescues the electrophysiological defects seen in 'caz1' mutants (FlyBase curator comment: this mutant corresponds to Df(1)383 onto which a transgene containing CG32576+t5.0 has been recombined to provide CG32576[+] function).

      (Machamer et al., 2014)

      cazT:Zzzz\FLAG fully rescues the reduced adult viability of males hemizygous for the 'caz1' mutant chromosome (Df(1)383 onto which a transgene containing CG32576+t5.0 has been recombined to provide CG32576[+] function). The reduced longevity, locomotion defects and external morphological defects of adult caz1/Y escapers are also fully rescued by cazT:Zzzz\FLAG.

      (Wang et al., 2011)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      cazT:Zzzz\FLAG
      cazTag:FLAG
      Name Synonyms
      Secondary FlyBase IDs
        References (3)