αPS3, Volado, Vol, PS3, E(Sev-CycE)E93
α-PS3 integrin - involved in dorsal closure, tracheal and salivary gland development and in the localization of pericardial cells - thought to dimerize with Myospheroid and possibly Integrin betanu subunit - Scb regulates adhesion, signalling, polarity and cell migration - genetic interaction with Laminin genes implicates them as extracellular matrix ligands
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
Heterodimer of an alpha and a beta subunit. The alpha subunit is composed of a heavy and a light chain linked by a disulfide bond. Interacts with mys/beta-PS and Itgbn.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\scb using the Feature Mapper tool.
scb appears in border cells and in stretch cells at oogenesis stage 10A. It is also strongly expressed in cells that will form the dorsal appendages at stages 10B and 11 and persists until stage 13.
The α3 integrin scb is generally enriched along the interface between the muscle layer and the epithelium of the midgut.
Co-localization with a hemocyte GFP marker shows that scb is present on the surface of embryonic hemocytes. A developmental western blot shows the hightest levels of scb protein in pupae and the lowest levels in larvae.
scb protein is observed starting in mid-oogenesis in dorsal appendage forming follicle cells, in stretch follicle cells, and in a posterior patch of follicle cells overlying the oocyte.
GBrowse - Visual display of RNA-Seq signalsView Dmel\scb in GBrowse 2
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
S2 cells treated with dsRNA generated against this gene show reduced phagocytosis of Candida albicans compared to untreated cells.
scb mutants display impaired olfactory memories within 3 minutes of training, indicating that the encoded α-integrin is required for short-term memory processes. Conditional expression of a scb transgene during adulthood rescues the memory impairment. Rescue is reversible, fading over time along with expression of the transgene.
The scb integrin, a cell surface protein predicted to mediate selective adhesion in response to activation by intracellular or extracellular signals, may participate in cell-cell interactions between mushroom bodies and these large interneurons underlying learning.
The gene has been known as 'Volado', a Chilean colloquialism with no English counterpart, which is loosely translated as 'forgetful' or 'absent-minded'. In Chile, it is often used in reference to professors and scientists.