FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
Allele: Dmel\scb1
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General Information
Symbol
Dmel\scb1
Species
D. melanogaster
Name
FlyBase ID
FBal0015260
Feature type
allele
Associated gene
Dmel\scb
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992, Tearle and Nusslein-Volhard, 1987)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Adult-generated scb1 homozygous mutant intestinal stem cell clones have reduced maintenance 7 days and 14 days after clone induction compared to control clones; remaining clones contain fewer cells by day 14; intestinal stem cells show no obvious signs of apoptosis.

      (Lin et al., 2013)

      Large somatic clones of scb1 mutant cells in the wing cause blistering. Smaller, dorsally located clones that touch or cross longitudinal veins cause broadening of the vein from 2-3 to 4-5 cells. In addition, some small clones are restricted to the center of veins and cause the vein to split into two vein-like territories separated by a central less pigmented intervein-like area. Clone that do not touch the wing veins, or that lie ventrally, have no effect on vein development.

      (Araujo et al., 2003)

      Embryos have small mid-dorsal hole with necrotic rim.

      (Lindsley and Zimm, 1992)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      scb[+]/scb1 is an enhancer of visible | dominant phenotype of sogEP7

      (Araujo et al., 2003)

      scb[+]/scb1 is an enhancer of visible | dominant phenotype of sogEP11

      (Araujo et al., 2003)
      Suppressor of
      Statement
      Reference

      scb[+]/scb1 is a suppressor of decreased occurrence of cell division phenotype of CycEJP

      (Brumby et al., 2004)
      Phenotype Manifest In
      Enhanced by
      Statement
      Reference

      scb1 has wing vein | dorsal | somatic clone phenotype, enhanceable by sog[+]/sogEP7

      (Araujo et al., 2003)
      Enhancer of
      Statement
      Reference

      scb[+]/scb1 is an enhancer of wing vein phenotype of sogEP7

      (Araujo et al., 2003)

      scb[+]/scb1 is an enhancer of wing vein phenotype of sogEP11

      (Araujo et al., 2003)
      Suppressor of
      Statement
      Reference

      scb1 is a suppressor of eye disc & S phase phenotype of CycEJP

      (Brumby et al., 2004)

      scb[+]/scb1 is a suppressor of eye phenotype of CycEJP

      (Brumby et al., 2004)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Suppresses the S phase defects seen in the CycEJP eye disc.

      (Brumby et al., 2004)

      The vein splitting phenotype due to small dorsal clones of scb1 mutant cells located in the middle of veins, is enhanced by sogEP7 : the resulting vein branches are much more distinct than those induced by such clones in a wild-type background.

      (Araujo et al., 2003)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      scab1
      (Levi et al., 2006)
      scb1
      (Lin et al., 2013, Christensen and Cook, 2007.10.29)
      scbIID
      (Lindsley and Zimm, 1992, Tearle and Nusslein-Volhard, 1987)
      Name Synonyms
      Secondary FlyBase IDs
        References (7)