FlyBase Allele Report: Dmel\scb[JF02696]

General Information

Symbol

Dmel\scb^JF02696

Species

D. melanogaster

Name

FlyBase ID

FBal0242284

Feature type

allele

Associated gene

Dmel\scb

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02696}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009)

Mutagen

in vitro construct

(Perkins et al., 2009)

Progenitor genotype

Carried in construct

P{TRiP.JF02696}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02696

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates tauopathy

modeled by Hsap\MAPT^V337M.UAS

(Shulman et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4^repo

(Tavares et al., 2015)

Phenotype Manifest In

embryonic/larval optic stalk | third instar larval stage, with Scer\GAL4^repo

(Tavares et al., 2015)

extracellular matrix | third instar larval stage, with Scer\GAL4^repo

(Tavares et al., 2015)

eye disc | third instar larval stage, with Scer\GAL4^repo

(Tavares et al., 2015)

eye photoreceptor cell | third instar larval stage, with Scer\GAL4^repo

(Tavares et al., 2015)

Detailed Description

Statement

Reference

Expressing scb^JF02696 under the control of Scer\GAL4^repo in third instar larvae (in combination with a Dicer-2 transgene to enhance RNAi efficiency) results in stalling photoreceptor axons in the optic stalk and a slightly thinner fenestrated membrane in this region. There is no impact on glial cell numbers and migration in the eye disc and optic stalk.

(Tavares et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

scb^JF02696, Scer\GAL4^repo is a suppressor of decreased rate of adult locomotory behavior phenotype of Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^repo

(Hernandez et al., 2023)

scb^JF02696, Scer\GAL4^elav-C155 is a suppressor of decreased rate of adult locomotory behavior | progressive phenotype of Hsap\HTT^{128Q.1-231.UAS}, Scer\GAL4^elav-C155

(Hernandez et al., 2023)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27545

y¹ v¹; P{TRiP.JF02696}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

scb^JF02696

Name Synonyms

Secondary FlyBase IDs

References (8)

Report Sections

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