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Yamazaki, D., Horiuchi, J., Nakagami, Y., Nagano, S., Tamura, T., Saitoe, M. (2007). The Drosophila DC0 mutation suppresses age-related memory impairment without affecting lifespan.  Nat. Neurosci. 10(4): 478--484.
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FBrf0201075
Publication Type
Research paper
Abstract

The study of age-related memory impairment (AMI) has been hindered by a lack of AMI-specific mutants. In a screen for such mutants in Drosophila melanogaster, we found that heterozygous mutations of DCO (DCO/+), which encodes the major catalytic subunit of cAMP-dependent protein kinase (PKA), delay AMI more than twofold without affecting lifespan or memory at early ages. AMI is restored when a DCO transgene is expressed in mushroom bodies, structures important for olfactory memory formation. Furthermore, increasing cAMP and PKA activity in mushroom bodies causes premature AMI, whereas reducing activity suppresses AMI. In Drosophila AMI consists of a specific reduction in memory dependent on the amnesiac (amn) gene. amn encodes putative neuropeptides that have been proposed to regulate cAMP levels in mushroom bodies. Notably, both the memory and AMI defects of amn mutants are restored in amn;DCO/+ double mutants, suggesting that AMI is caused by an age-related disruption of amn-dependent memory via PKA activity in mushroom bodies.

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Secondary IDs
  • FBrf0194168
Language of Publication
English
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Publication Type
Journal
Abbreviation
Nat. Neurosci.
Title
Nature Neuroscience
Publication Year
1998-
ISBN/ISSN
1097-6256
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