FlyBase Allele Report: Scer\GAL4[Alp4-c232]

(Flybrain Neuron Database et al., 2018.6.28, Chen et al., 2012, Young and Armstrong, 2010, Baker et al., 2007, Yang et al., 2000, Renn et al., 1999)

ellipsoid body

(Yang et al., 2000, Connolly et al., 1996)

adult ellipsoid body ring neuron R4 | distal | subset

(Renn et al., 1999)

ellipsoid body | restricted

(Young and Armstrong, 2010, Zars et al., 2000, Renn et al., 1999)

large field neuron | subset

(Renn et al., 1999)

adult brain | restricted

(Connolly et al., 1996)

adult ellipsoid body ring neuron R4d

(Flybrain Neuron Database et al., 2018.6.28, Chen et al., 2012, Young and Armstrong, 2010)

adult ellipsoid body ring neuron R4

(Baker et al., 2007, Yang et al., 2000)

adult ellipsoid body ring neuron R3 | subset

(Bridi et al., 2019)

adult ellipsoid body ring neuron R4d | subset

(Bridi et al., 2019)

lower segment of Malpighian tubule

(Yang et al., 2000, Sozen et al., 1997)

ureter

(Yang et al., 2000, Sozen et al., 1997)

adult ellipsoid body ring neuron

(Turner-Evans et al., 2020)

Additional Information

Statement

Reference

Drives expression in the ellipsoid body, and in a subset of ring neurons.

(FlyBase Curators, 2017)

Expression is limited to just a few cell types. In the brain, expression is found in the ring neurons of the ellipsoid body, specifically in the R3 and R4 morphological subtypes. In addition, expression is observed in the lower section and ureter of the Malpighian tubules.

(Yang et al., 2000)

Adult expression is observed in a subset of ring neurons of the ellipsoid body. Representative images can be seen Figure 4 of FBrf0127414.

(Zars et al., 2000)

Adult expression is observed in R3 ring neurons and in the subset of R4 neurons that arborize in the distal part of the ellipsoid body.

(Renn et al., 1999)

In adults, expressed in the Malpighian tubules; expression confined to the lower segment of Malpighian tubule and the ureter. Expression is not observed in the initial or main segements of the Malpighian tubule. Marks the lower tubule as a separate domain of the main segment.

(Sozen et al., 1997)

Marker for

adult ellipsoid body ring neuron

(Turner-Evans et al., 2020, Zars et al., 2000)

adult ellipsoid body ring neuron R3

(Renn et al., 1999)

adult ellipsoid body ring neuron R4d

(Renn et al., 1999)

ellipsoid body

(Renn et al., 1999)

lower segment of Malpighian tubule

(Sozen et al., 1997)

Reflects expression of

Alp4

(Turner-Evans et al., 2020, Young and Armstrong, 2010, Young and Armstrong, 2010, Baker et al., 2007, Yang et al., 2000)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Inhibition (using shi^1.UAS at 32[o]C) of Scer\GAL4^Alp4-c232 cells in adults does not affect startle-induced climbing behavior, compared to controls.

Thermogenetic activation (using TrpA1^UAS.(B).cKa at 32[o]C) of Scer\GAL4^Alp4-c232 cells in adults does not affect startle-induced climbing behavior, compared to controls.

(Sun et al., 2018)

Inhibition (using Hsap\KCNJ2^AAE.UAS.EGFP) of Scer\GAL4^Alp4-c232 cells in adults significantly reduces the preference to orient towards a dark vertical bar on the side where the same bar had not been shown previously, rather than a bar on the side where the same bar had been transiently shown previously, compared to controls; there is no effect on innate left/right preference between two dark vertical bars, or ability to orient towards a single bar, compared to controls.

(Shiozaki and Kazama, 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Scer\GAL4^Alp4-c232/Ggt-1^UAS.cLa rescues Ggt-1^Δ1523

(Liu et al., 2014)

Scer\GAL4^Alp4-c232/bs^UAS.cHa rescues bs²

(Thran et al., 2013)

Scer\GAL4^Alp4-c232/ebo^UAS.cTa rescues ebo⁶⁷⁸

(Thran et al., 2013)

Partially rescues

Scer\GAL4^Alp4-c232/kcc^UAS.cHb partially rescues kcc^DHS1

(Hekmat-Scafe et al., 2010)

Fails to rescue

pdm3^UAS.CFP/Scer\GAL4^Alp4-c232 fails to rescue pdm3¹

(Chen et al., 2012)

Scer\GAL4^Alp4-c232/Dop1R1^UAS.cKa fails to rescue Dop1R1^f02676

(Kong et al., 2010)

Su(H)^UAS.cPa/Scer\GAL4^Alp4-c232 fails to rescue Su(H)⁸

(Song et al., 2009)

for^UAS.cWa/Scer\GAL4^Alp4-c232 fails to rescue for^s

(Wang et al., 2008)

Scer\GAL4^Alp4-c232/spoon^UAS.cYa fails to rescue spoon^P1

(Lu et al., 2007)

Scer\GAL4^Alp4-c232/Ptp10D^UAS.cQa fails to rescue Ptp10D^chi

(Qian et al., 2007)

Scer\GAL4^Alp4-c232/homer^UAS.Tag:MYC fails to rescue homer^R102

(Urizar et al., 2007)

Scer\GAL4^Alp4-c232/Adcy1^UAS.cZa fails to rescue Adcy1^rut-2080

(Zars et al., 2000)

Scer\GAL4^Alp4-c232/Adcy1^UAS.cZa fails to rescue Adcy1^rut-2080

(Zars et al., 2000)

Comments

Expression of Su(H)^Scer\UAS.cPa under the control of Scer\GAL4^Aph-4-c232 (using the temperature sensitive Scer\GAL80^ts.αTub84B allele to limit expression to the adult stage) does not rescue the reduced 24 hour memory phenotype seen in Su(H)⁸ homozygotes.

(Song et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

30828

w^*; P{GawB}Alp4^c232

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

C232

(DeZazzo et al., 2000)

GAL4^c232

Scer\GAL4^Alp4-c232

Scer\GAL4^Aph-4-c232

Scer\GAL4^c232

Name Synonyms

Secondary FlyBase IDs

References (85)

Report Sections

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