FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\homerUAS.Tag:MYC
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General Information
Symbol
Dmel\homerUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0135704
Feature type
allele
Associated gene
Dmel\homer
Associated Insertion(s)
Carried in Construct
P{UAS-homer.Myc}
Also Known As
UAS-homer-myc
Key Links
Transgenic product class
cDNA
(Diagana et al., 2002)
wild_type
(Diagana et al., 2002)
Mutagen
Nature of the Allele
Transgenic product class
cDNA
(Diagana et al., 2002)
wild_type
(Diagana et al., 2002)
Mutagen
in vitro construct
(Diagana et al., 2002)
Progenitor genotype
Carried in construct
P{UAS-homer.Myc}
Cytology
Description

Six copies of Tag:MYC are fused in-frame to the C-terminus of the homer full length cDNA LD03156 - the expression of the resulting protein is governed by UASt regulatory sequences.

(Diagana et al., 2002)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
homer
Tagged with
Tag:MYC
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Overexpression of homerScer\UAS.T:Hsap\MYC in the nervous system under the control of Scer\GAL4elav-C155 does not alter ethanol sensitivity nor does it alter rapid ethanol tolerance.

      (Urizar et al., 2007)

      When expression is driven by Scer\GAL4elav-C155 no pathfinding errors occur in the embryonic ventral nerve cord.

      (Diagana et al., 2002)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Scer\GAL4elav-C155/homerUAS.Tag:MYC rescues homerR102

      (Urizar et al., 2007)

      homerUAS.Tag:MYC/Scer\GAL4c819 rescues homerR102

      (Urizar et al., 2007)

      Scer\GAL4c42/homerUAS.Tag:MYC rescues homerR102

      (Urizar et al., 2007)
      Fails to rescue

      Scer\GAL4c522/homerUAS.Tag:MYC fails to rescue homerR102

      (Urizar et al., 2007)

      Scer\GAL4121Y/homerUAS.Tag:MYC fails to rescue homerR102

      (Urizar et al., 2007)

      Scer\GAL4Mef2.247/homerUAS.Tag:MYC fails to rescue homerR102

      (Urizar et al., 2007)

      homerUAS.Tag:MYC/Scer\GAL4103Y fails to rescue homerR102

      (Urizar et al., 2007)

      homerUAS.Tag:MYC/Scer\GAL4c107 fails to rescue homerR102

      (Urizar et al., 2007)

      homerUAS.Tag:MYC/Scer\GAL4Ilp2.PR fails to rescue homerR102

      (Urizar et al., 2007)

      Scer\GAL4078Y/homerUAS.Tag:MYC fails to rescue homerR102

      (Urizar et al., 2007)

      Scer\GAL4Alp4-c232/homerUAS.Tag:MYC fails to rescue homerR102

      (Urizar et al., 2007)

      Scer\GAL4c105/homerUAS.Tag:MYC fails to rescue homerR102

      (Urizar et al., 2007)

      Scer\GAL4c481/homerUAS.Tag:MYC fails to rescue homerR102

      (Urizar et al., 2007)

      homerUAS.Tag:MYC/Scer\GAL4lilli-189Y fails to rescue homerR102

      (Urizar et al., 2007)

      homerUAS.Tag:MYC/Scer\GAL4c302 fails to rescue homerR102

      (Urizar et al., 2007)
      Comments

      Pan-neuronal expression of homerScer\UAS.T:Hsap\MYC restores the ethanol sensitivity and rapid tolerance phenotypes of homerR102 homozygous males to control levels.

      Expression of homerScer\UAS.T:Hsap\MYC in various subsections of the brain under the control of Scer\GAL4c522, Scer\GAL4121Y, Scer\GAL4247, Scer\GAL4103Y, Scer\GAL4c107, Scer\GAL4Ilp2.PR, Scer\GAL4078Y, Scer\GAL4Aph-4-c232, Scer\GAL4c105, Scer\GAL4c481, Scer\GAL4lilli-189Y or Scer\GAL4c302 does not affect ethanol sensitivity in homerR102 mutant male flies.

      Expression of homerScer\UAS.T:Hsap\MYC in the R2 and R4m Ring neurons of the ellipsoid body under the control of Scer\GAL4c819 or Scer\GAL4c42 results in significant rescue of the homerR102 ethanol sensitivity and rapid tolerance phenotype.

      (Urizar et al., 2007)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      homerScer\UAS.T:Hsap\MYC
      homerUAS.Tag:MYC
      Name Synonyms
      Secondary FlyBase IDs
        References (5)