FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Dop1R1UAS.cKa
Open Close
General Information
Symbol
Dmel\Dop1R1UAS.cKa
Species
D. melanogaster
Name
FlyBase ID
FBal0277733
Feature type
allele
Associated gene
Dmel\Dop1R1
Associated Insertion(s)
Carried in Construct
P{UAS-Dop1R1.K}
Key Links
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Kong et al., 2010)
Progenitor genotype
Carried in construct
P{UAS-Dop1R1.K}
Cytology
Description

UASt regulatory sequences drive expression of Dop1R1 coding sequences starting from exon 2 onwards (i.e. from the first intron, thereby missing the first predicted translation start site).

(Kong et al., 2010)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Dop1R1
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  depressive disorder
      CEA
      (Jia et al., 2021)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of DopRScer\UAS.cKa under the control of Scer\GAL4ey-OK107 in a homozygous DopRf02676 background (which will also result in the expression of DopR from the Scer\UAS regulatory sequences present in the insertion in DopRf02676) results in a severe defect in long-term olfactory memory measured 24 hours after spaced repetitive training.

      (Li et al., 2013)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescues

      Dop1R1UAS.cKa/Scer\GAL45.30 rescues Dop1R1f02676

      (Kong et al., 2010)

      Dop1R1UAS.cKa/Scer\GAL411.148 rescues Dop1R1f02676

      (Kong et al., 2010)

      Dop1R1UAS.cKa/Scer\GAL4lilli-189Y rescues Dop1R1f02676

      (Kong et al., 2010)
      Fails to rescue

      Scer\GAL4Alp4-c232/Dop1R1UAS.cKa fails to rescue Dop1R1f02676

      (Kong et al., 2010)

      Dop1R1UAS.cKa/Scer\GAL417d fails to rescue Dop1R1f02676

      (Kong et al., 2010)

      Scer\GAL4Tab2-201Y/Dop1R1UAS.cKa fails to rescue Dop1R1f02676

      (Kong et al., 2010)
      Comments

      Flies of the genotype Scer\GAL45.30/+; DopRf02676/DopRf02676 show selectively restored expression of DopR. Those flies that had restored expression in patterns that include the R2/R4 class ellipsoid body neurons exhibit rescue of ethanol-induced hyperactivity. Restoring DopR expression in the R3 neurons of the ellipsoid body neurons (through Scer\GAL4lilli-189Y) results in a modest but statistically significant increase in ethanol-induced hyperactivity. However, expression with Scer\GAL4Aph-4-c232 has no effect on ethanol induced hyperactivity in DopRf02676 homozygous mutants.

      (Kong et al., 2010)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      Dop1R1Scer\UAS.cKa
      Dop1R1UAS.cKa
      DopRScer\UAS.cKa
      Name Synonyms
      Secondary FlyBase IDs
        References (3)