FlyBase Allele Report: Dmel\Ggt-1[Δ1523]

General Information

Symbol

Dmel\Ggt-1^Δ1523

Species

D. melanogaster

Name

FlyBase ID

FBal0298273

Feature type

allele

Associated gene

Dmel\Ggt-1

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

amorphic allele - molecular evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - molecular evidence

(Liu et al., 2014)

Mutagen

Delta2-3 transposase

(Liu et al., 2014)

Progenitor genotype

P{GawB}Ggt-1^NP0136

(Liu et al., 2014)

Cytology

Description

Imprecise excision of the progenitor P{GawB}Ggt-1^NP0136 insertion, resulting in a 1523bp deletion in Ggt-1.

(Liu et al., 2014)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal behavior | larval stage

(Liu et al., 2014)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous larvae show significantly increased green-light avoidance compared to controls, but blue-light avoidance is normal in the mutant larvae. This phenotype can be suppressed by feeding with glutamic acid exceeding concentrations of 20μM.

(Liu et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Suppressor of

Statement

Reference

Ggt-1^Δ1523 is a non-suppressor of abnormal behavior | larval stage phenotype of Rh6¹

(Liu et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

The reduced green-light avoidance seen in Rh6¹ larvae is not altered if the larvae are also mutant for Ggt-1^Δ1523.

(Liu et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Ggt-1^Δ1523 is rescued by Scer\GAL4^Act.PU/Ggt-1^UAS.cLa

(Liu et al., 2014)

Ggt-1^Δ1523 is rescued by Scer\GAL4^c42/Ggt-1^UAS.cLa

(Liu et al., 2014)

Ggt-1^Δ1523 is rescued by Scer\GAL4^Alp4-c232/Ggt-1^UAS.cLa

(Liu et al., 2014)

Not rescued by

Ggt-1^Δ1523 is not rescued by Scer\GAL4^elav.PU/Ggt-1^UAS.cLa

(Liu et al., 2014)

Ggt-1^Δ1523 is not rescued by Scer\GAL4^repo.PU/Ggt-1^UAS.cLa

(Liu et al., 2014)

Ggt-1^Δ1523 is not rescued by Scer\GAL4^NP3609/Ggt-1^UAS.cLa

(Liu et al., 2014)

Comments

Expression of Ggt-1^Scer\UAS.cLa under the control of either Scer\GAL4^Act.PU, Scer\GAL4^c42 or Scer\GAL4^Aph-4-c232 fully rescues the increased green-light avoidance seen in Ggt-1^Δ1523 larvae compared to controls.

Expression of Ggt-1^Scer\UAS.cLa under the control of either Scer\GAL4^elav.PU, Scer\GAL4^repo.PU or Scer\GAL4^Gug-NP3609 does not rescue the increased green-light avoidance seen in Ggt-1^Δ1523 larvae compared to controls.

(Liu et al., 2014)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ggt-1^Δ1523

(Liu et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (1)

Report Sections

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