FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Pka-C1B12
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General Information
Symbol
Dmel\Pka-C1B12
Species
D. melanogaster
Name
FlyBase ID
FBal0033954
Feature type
allele
Associated gene
Dmel\Pka-C1
Associated Insertion(s)
Carried in Construct
Also Known As
DC0B12
Key Links
Genomic Maps

Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    Amino acid replacement: G128S.

    (Lane and Kalderon, 1993)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    point_mutation
    2L:9,697,185..9,697,185 [-]
    Nucleotide change:

    G9697185A

    Reported nucleotide change:

    G2505A

    Amino acid change:

    G128S | Pka-C1-PB; G128S | Pka-C1-PC; G128S | Pka-C1-PD

    Reported amino acid change:

    G128S

    (Lane and Kalderon, 1993)
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 0 )
        Disease
        Interaction
        References
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Transheterozygotes for weak Pka-C1 alleles are lethal at 18oC. Hemizygotes are larval lethal with some adult escapers.

        (Lane and Kalderon, 1993)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Rescued by

        Pka-C1B12 is rescued by Pka-C1+mTgDC0

        (Lane and Kalderon, 1993)
        Comments

        One copy of Pka-C1+mTgDC0 provides full rescue of hemizygotes.

        (Lane and Kalderon, 1993)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        Comments
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        DC0B12
        (Horiuchi et al., 2008, Yamazaki et al., 2007, Li et al., 1996)
        Pka-C1B12
        Name Synonyms
        Secondary FlyBase IDs
          References (5)