FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Gene: Dmel\Vap33
Open Close
General Information
Symbol
Dmel\Vap33
Species
D. melanogaster
Name
VAMP-associated protein 33kDa
Annotation Symbol
CG5014
Feature Type
protein_coding_gene
FlyBase ID
FBgn0029687
Gene Model Status
Current
Stock Availability
15 publicly available
Gene Summary
VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. [Date last reviewed: 2019-03-21] (FlyBase Gene Snapshot)
All Summaries
Also Known As

Vap-33-1, VAP, DVAP, DVAP-33A, dVAP-A

Key Links
Genomic Location
Cytogenetic map
3F9-3F9
Sequence location
Recombination map
1-5
RefSeq locus
NC_004354 REGION:3948975..3955442
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (23 terms)
Molecular Function (2 terms)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
enables peroxisome-endoplasmic reticulum membrane tether activity
inferred from mutant phenotype
(Kors et al., 2024)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
enables protein-membrane adaptor activity
inferred from biological aspect of ancestor with PANTHER:PTN000087323
(GO Reference Genome Project, 2011-)
Biological Process (11 terms)
Terms Based on Experimental Evidence (7 terms)
CV Term
Evidence
References
involved_in axo-dendritic transport
inferred from mutant phenotype
(Forrest et al., 2013)
involved_in cytoplasmic microtubule organization
inferred from mutant phenotype
(Forrest et al., 2013)
involved_in defense response to Gram-negative bacterium
inferred from mutant phenotype
(Berkey et al., 2009)
involved_in neuromuscular junction development
inferred from mutant phenotype
(Chai et al., 2008, Pennetta et al., 2002)
involved_in phosphatidylinositol metabolic process
inferred from mutant phenotype
(Forrest et al., 2013)
involved_in positive regulation of hippo signaling
inferred from mutant phenotype
(Portela et al., 2024)
involved_in synapse maturation
inferred from mutant phenotype
(Forrest et al., 2013)
Terms Based on Predictions or Assertions (4 terms)
CV Term
Evidence
References
involved_in endoplasmic reticulum membrane organization
inferred from biological aspect of ancestor with PANTHER:PTN000087323
(GO Reference Genome Project, 2011-)
involved_in endoplasmic reticulum-plasma membrane tethering
inferred from biological aspect of ancestor with PANTHER:PTN000087323
(GO Reference Genome Project, 2011-)
involved_in neurotransmitter secretion
non-traceable author statement
(Lloyd et al., 2000)
involved_in synaptic vesicle priming
non-traceable author statement
(Lloyd et al., 2000)
Cellular Component (10 terms)
Terms Based on Experimental Evidence (9 terms)
CV Term
Evidence
References
is_active_in cholinergic synapse
inferred from direct assay
(Pennetta et al., 2002)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
is_active_in endoplasmic reticulum membrane
inferred from direct assay
(Kors et al., 2024)
located_in endoplasmic reticulum
inferred from direct assay
(Moustaqim-Barrette et al., 2014, Chen et al., 2010, Tsuda et al., 2008)
located_in extracellular space
inferred from direct assay
(Tsuda et al., 2008)
is_active_in neuromuscular junction
inferred from direct assay
(Pennetta et al., 2002)
located_in plasma membrane
inferred from direct assay
(Tsuda et al., 2008)
is_active_in presynaptic cytoskeleton
inferred from direct assay
(Pennetta et al., 2002)
is_active_in presynaptic membrane
inferred from direct assay
(Pennetta et al., 2002)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
is_active_in endoplasmic reticulum membrane
inferred from biological aspect of ancestor with PANTHER:PTN000087323
(GO Reference Genome Project, 2011-)
located_in endoplasmic reticulum membrane
inferred from electronic annotation with InterPro:IPR016763
(InterPro Project Members, 2004-)
is_active_in plasma membrane
inferred from biological aspect of ancestor with PANTHER:PTN000087323
(GO Reference Genome Project, 2011-)
located_in synaptic vesicle
non-traceable author statement
(Lloyd et al., 2000)
Gene Group (FlyBase)
Pathway (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Summaries
Gene Snapshot
VAMP-associated protein 33kDa (Vap33) encodes a protein that plays a conserved role in synaptic homeostasis. It controls a number of processes which depend on phosphoinositide levels, such as synaptic growth and axonal transport. It binds to the product of Sac1 to maintain normal levels of phosphoinositides and to the product of Dscam1 to affect its localization within axonal projections. [Date last reviewed: 2019-03-21]
Pathway (FlyBase)
POSITIVE REGULATORS OF HIPPO SIGNALING PATHWAY -
The Hippo signaling pathway is an intracellular kinase cascade in which hpo kinase in complex with sav, phosphorylates wts kinase which, in turn, phosphorylates yki transcriptional co-activator leading to its cytosolic retention. Positive regulators of the pathway, enhance the cytosolic retention of yki, negatively regulating tissue growth (Adapted from FBrf0224870).
Summary (Interactive Fly)

cleaved secreted ligand for Eph receptors - plays a conserved role in synaptic homeostasis

Gene Model and Products
Number of Transcripts
4
Number of Unique Polypeptides
2

Please see the JBrowse view of Dmel\Vap33 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q9W4N8)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Annotated transcripts do not represent all supported alternative splices within 5' UTR.

Gene model reviewed during 5.51

Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Vap33-RA
FBtr0070617
NM_206625
2439
235
Vap33-RB
FBtr0070616
NM_130731
2541
269
Vap33-RC
FBtr0070618
NM_206624
3607
269
Vap33-RE
FBtr0342739
NM_206623
3897
269
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Vap33-PA
FBpp0089169
26.8
235
8.61
Q7KVX5
NP_996348
AAS72340
Vap33-PB
FBpp0070589
29.5
269
7.95
Q9W4N8
NP_570087
AAF45909
Vap33-PC
FBpp0089170
29.5
269
7.95
Q9W4N8
NP_996347
AAS72339
Vap33-PE
FBpp0309607
29.5
269
7.95
Q9W4N8
NP_996346
AAS72341
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

269 aa isoforms: Vap33-PB, Vap33-PC, Vap33-PE
Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vap33 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-1.71

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
immunolocalization
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
cell
(Tsuda et al., 2008)
cell
(Tsuda et al., 2008)
(Tsuda et al., 2008)
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
is_active_in cholinergic synapse
inferred from direct assay
(Pennetta et al., 2002)
located_in endomembrane system
inferred from high throughput direct assay
(Tan et al., 2009)
is_active_in endoplasmic reticulum membrane
inferred from direct assay
(Kors et al., 2024)
located_in endoplasmic reticulum
inferred from direct assay
(Moustaqim-Barrette et al., 2014, Chen et al., 2010, Tsuda et al., 2008)
located_in extracellular space
inferred from direct assay
(Tsuda et al., 2008)
is_active_in neuromuscular junction
inferred from direct assay
(Pennetta et al., 2002)
located_in plasma membrane
inferred from direct assay
(Tsuda et al., 2008)
is_active_in presynaptic cytoskeleton
inferred from direct assay
(Pennetta et al., 2002)
is_active_in presynaptic membrane
inferred from direct assay
(Pennetta et al., 2002)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Vap33 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 15 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 23 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Vap33
Transgenic constructs containing regulatory region of Vap33
Aberrations (Deficiencies and Duplications) ( 0 )
Inferred from experimentation ( 0 )
Inferred from location ( 8 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal
lethal, with Scer\GAL4Act.PU
lethal, with Scer\GAL4elav.PU
lethal, with Scer\GAL4Tub.PU
lethal | heat sensitive, with Scer\GAL4how-24B
lethal | heat sensitive, with Scer\GAL4Tub.PU
lethal | recessive
lethal - all die before end of larval stage
lethal - all die before end of larval stage, with Scer\GAL4how-24B
lethal - all die before end of larval stage | recessive
lethal - all die before end of P-stage, with Scer\GAL4G14
partially lethal - majority die | female
partially lethal - majority die | male
partially lethal - majority die | recessive
viable
viable, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
viable, with Scer\GAL4Act.PU
viable, with Scer\GAL4elav.PLu
viable, with Scer\GAL4pnr-MD237
viable, with Scer\GAL4repo
viable, with Scer\GAL4tin.CΔ4
Sterility
Allele
fertile
Other Phenotypes
Allele
abnormal flight, with Scer\GAL4elav-C155
abnormal flight | progressive, with Vap33ALS8
abnormal flight | progressive, with Vap33Δ31
abnormal locomotor rhythm, with Scer\GAL4elav-C155
abnormal neuroanatomy
abnormal neuroanatomy, with Scer\GAL4C164
abnormal neuroanatomy, with Scer\GAL4elav.PU
abnormal neuroanatomy, with Scer\GAL4elav-C155
abnormal neuroanatomy, with Scer\GAL4RapGAP1-OK6
abnormal neuroanatomy | adult stage
abnormal neuroanatomy | adult stage, with Vap33ALS8
abnormal neuroanatomy | adult stage, with Vap33Δ31
abnormal neuroanatomy | adult stage | somatic clone
abnormal neuroanatomy | larval stage
abnormal neuroanatomy | larval stage, with Scer\GAL4C57
abnormal neuroanatomy | third instar larval stage
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4elav.PLu
abnormal neuroanatomy | third instar larval stage, with Scer\GAL4RapGAP1-OK6
abnormal neurophysiology
abnormal neurophysiology, with Scer\GAL4elav-C155
abnormal neurophysiology | adult stage
abnormal neurophysiology | adult stage, with Scer\GAL4GMR.PF
abnormal neurophysiology | adult stage | progressive, with Vap33ALS8
abnormal neurophysiology | adult stage | progressive, with Vap33Δ31
abnormal pain response | adult stage, with Dcr-2UAS.cDa, Scer\GAL4elav.PLu
abnormal size, with Scer\GAL4ey.PU
decreased cell number | adult stage | progressive | somatic clone
increased cell death, with Scer\GAL4elav-C155
majority die during pupal stage, with Scer\GAL4elav-C155
short lived, with Vap33ALS8
short lived, with Vap33Δ31
some die during larval stage
some die during larval stage, with Scer\GAL4how-24B
some die during larval stage | recessive
some die during pharate adult stage
some die during pharate adult stage, with Scer\GAL4G14
some die during pupal stage
uncoordinated, with Scer\GAL4elav-C155
visible, with Scer\GAL4ey.PU
visible, with Scer\GAL4pnr-MD237
visible, with Scer\GAL4sca.PU
Phenotype manifest in
Allele
adult cerebrum, with Vap33ALS8
adult cerebrum, with Vap33Δ31
adult mushroom body alpha-lobe | pupal stage
adult optic lobe, with Vap33ALS8
adult optic lobe, with Vap33Δ31
axon | adult stage, with Scer\GAL4nSyb.PS
bouton
bouton, with Scer\GAL4C164
bouton, with Scer\GAL4elav-C155
bouton & microtubule
bouton & microtubule, with Scer\GAL4C164
dendrite | adult stage | somatic clone
endoplasmic reticulum
endoplasmic reticulum, with Scer\GAL4C57
endoplasmic reticulum, with Scer\GAL4cv-c-C5
endoplasmic reticulum, with Scer\GAL4elav.PU
endoplasmic reticulum, with Vap33ALS8
endoplasmic reticulum, with Vap33Δ31
eye, with Scer\GAL4ey.PU
eye photoreceptor cell, with Scer\GAL4ey.PU
Golgi apparatus | adult stage | somatic clone
indirect flight muscle cell, with Scer\GAL4elav-C155
interommatidial bristle, with Scer\GAL4ey.PU
interommatidial bristle | increased number, with Scer\GAL4ey.PU
macrochaeta, with Scer\GAL4sca.PU
mesonotum, with Scer\GAL4pnr-MD237
microtubule, with Scer\GAL4elav-C155
mitochondrion
mitochondrion | adult stage | somatic clone
neuromuscular junction, with Scer\GAL4elav-C155
neuromuscular junction | larval stage
NMJ bouton
NMJ bouton, with Scer\GAL4elav.PLu
NMJ bouton, with Scer\GAL4elav.PU
NMJ bouton, with Scer\GAL4elav-C155
NMJ bouton, with Scer\GAL4RapGAP1-OK6
NMJ bouton | larval stage, with Scer\GAL4C57
nucleus, with Scer\GAL4C57
nucleus, with Scer\GAL4elav-C155
ommatidium, with Scer\GAL4ey.PU
peroxisome | adult stage, with Scer\GAL4nSyb.PS
photoreceptor neuron, with Scer\GAL4ey.PU
projection neuron | adult stage | decreased number | somatic clone
retina | adult stage, with Scer\GAL4GMR.PF
somatic muscle cell, with Scer\GAL4C57
synapse
synapse, with Scer\GAL4C57
synapse, with Scer\GAL4C164
synapse, with Scer\GAL4elav-C155
terminal bouton, with Scer\GAL4elav-C155
trichogen cell, with Scer\GAL4pnr-MD237
type I bouton | larval stage
wing disc, with Scer\GAL4cv-c-C5
wing nerve | adult stage, with Scer\GAL4nSyb.PS
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (5)
Hsap\VAPB
13 of 14
Yes
Yes
 
4  
Hsap\VAPA
12 of 14
No
Yes
Hsap\MOSPD3
2 of 14
No
Yes
Hsap\MOSPD1
1 of 14
No
Yes
Hsap\MOSPD2
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (6)
Rnor\Vapb
13 of 14
Yes
Yes
Rnor\Mospd4
12 of 14
No
Yes
Rnor\Vapa
12 of 14
No
Yes
Rnor\Mospd3
2 of 14
No
Yes
Rnor\Mospd1
1 of 14
No
Yes
Rnor\Mospd2
1 of 14
No
No
Mus musculus (laboratory mouse) (5)
Mmus\Vapa
12 of 14
Yes
Yes
Mmus\Vapb
12 of 14
Yes
Yes
Mmus\Mospd2
2 of 14
No
No
Mmus\Mospd3
2 of 14
No
Yes
Mmus\Mospd1
1 of 14
No
Yes
Xenopus tropicalis (Western clawed frog) (5)
Xtro\vapa
9 of 13
Yes
Yes
Xtro\vapb
8 of 13
No
Yes
Xtro\il4i1
1 of 13
No
Yes
Xtro\necab2
1 of 13
No
Yes
Xtro\pcdh9
1 of 13
No
Yes
Danio rerio (Zebrafish) (5)
Drer\vapb
13 of 14
Yes
Yes
Drer\vapal
11 of 14
No
Yes
Drer\mospd1
1 of 14
No
Yes
Drer\mospd2
1 of 14
No
No
Drer\vapa
1 of 14
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (77)
Cele\vpr-1
12 of 14
Yes
Yes
Cele\F42G2.5
8 of 14
No
Yes
Cele\ZC196.2
5 of 14
No
Yes
Cele\F54H5.3
4 of 14
No
Yes
Cele\C10H11.7
2 of 14
No
Yes
Cele\C15H11.1
2 of 14
No
Yes
Cele\F52F12.8
2 of 14
No
Yes
Cele\F57A10.2
2 of 14
No
Yes
Cele\F58E6.5
2 of 14
No
Yes
Cele\K05F1.9
2 of 14
No
Yes
Cele\R05D3.5
2 of 14
No
Yes
Cele\T22B3.3
2 of 14
No
Yes
Cele\ZC262.1
2 of 14
No
Yes
Cele\ZK354.7
2 of 14
No
Yes
Cele\ZK688.12
2 of 14
No
Yes
Cele\C15H11.13
1 of 14
No
Yes
Cele\C25A8.1
1 of 14
No
Yes
Cele\C34D10.1
1 of 14
No
Yes
Cele\C35E7.9
1 of 14
No
Yes
Cele\C36H8.1
1 of 14
No
Yes
Cele\F36H12.3
1 of 14
No
Yes
Cele\F38H4.6
1 of 14
No
No
Cele\F58A6.9
1 of 14
No
Yes
Cele\hpo-28
1 of 14
No
No
Cele\M199.2
1 of 14
No
Yes
Cele\msp-3
1 of 14
No
Yes
Cele\msp-10
1 of 14
No
Yes
Cele\msp-19
1 of 14
No
Yes
Cele\msp-31
1 of 14
No
Yes
Cele\msp-32
1 of 14
No
Yes
Cele\msp-33
1 of 14
No
Yes
Cele\msp-36
1 of 14
No
Yes
Cele\msp-38
1 of 14
No
Yes
Cele\msp-40
1 of 14
No
Yes
Cele\msp-45
1 of 14
No
Yes
Cele\msp-49
1 of 14
No
Yes
Cele\msp-50
1 of 14
No
Yes
Cele\msp-51
1 of 14
No
Yes
Cele\msp-53
1 of 14
No
Yes
Cele\msp-55
1 of 14
No
Yes
Cele\msp-56
1 of 14
No
Yes
Cele\msp-57
1 of 14
No
Yes
Cele\msp-58
1 of 14
No
Yes
Cele\msp-59
1 of 14
No
Yes
Cele\msp-63
1 of 14
No
Yes
Cele\msp-64
1 of 14
No
Yes
Cele\msp-65
1 of 14
No
Yes
Cele\msp-74
1 of 14
No
Yes
Cele\msp-76
1 of 14
No
Yes
Cele\msp-77
1 of 14
No
Yes
Cele\msp-78
1 of 14
No
Yes
Cele\msp-79
1 of 14
No
Yes
Cele\msp-81
1 of 14
No
Yes
Cele\msp-113
1 of 14
No
Yes
Cele\msp-142
1 of 14
No
Yes
Cele\msp-152
1 of 14
No
Yes
Cele\ssp-19
1 of 14
No
Yes
Cele\ssp-31
1 of 14
No
Yes
Cele\ssp-32
1 of 14
No
Yes
Cele\ssp-35
1 of 14
No
Yes
Cele\ssp-36
1 of 14
No
Yes
Cele\T05D4.5
1 of 14
No
No
Cele\W08E3.4
1 of 14
No
No
Cele\Y38F2AR.10
1 of 14
No
Yes
Cele\Y50E8A.2
1 of 14
No
Yes
Cele\Y53C10A.15
1 of 14
No
Yes
Cele\Y53F4B.19
1 of 14
No
Yes
Cele\Y59E9AR.1
1 of 14
No
Yes
Cele\Y59E9AR.7
1 of 14
No
Yes
Cele\Y59H11AM.1
1 of 14
No
Yes
Cele\Y105C5B.19
1 of 14
No
Yes
Cele\Y116A8A.2
1 of 14
No
Yes
Cele\Y116A8A.7
1 of 14
No
Yes
Cele\ZK973.4
1 of 14
No
Yes
Cele\ZK1240.6
1 of 14
No
Yes
Cele\ZK1248.4
1 of 14
No
Yes
Cele\ZK1248.17
1 of 14
No
Yes
Anopheles gambiae (African malaria mosquito) (2)
Agam\AgaP_AGAP000626
12 of 12
Yes
Yes
Agam\AgaP_AGAP005556
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (10)
Atha\AT5G47180
10 of 13
Yes
Yes
Atha\AT4G00170
9 of 13
No
Yes
Atha\PVA12
9 of 13
No
Yes
Atha\VAP27-1
9 of 13
No
Yes
Atha\AT2G23830
8 of 13
No
Yes
Atha\VAP27-2
7 of 13
No
Yes
Atha\AT1G51270
5 of 13
No
Yes
Atha\AT4G21450
4 of 13
No
No
Atha\AT4G05060
3 of 13
No
No
Atha\MAMI
3 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (2)
Scer\SCS2
10 of 13
Yes
Yes
Scer\SCS22
8 of 13
No
Yes
Schizosaccharomyces pombe (Fission yeast) (2)
Spom\SPAC17C9.12
9 of 12
Yes
Yes
Spom\SPBC16G5.05c
9 of 12
Yes
Yes
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Vap33. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (4)
fan
9 of 13
CG33523
2 of 13
CG6527
1 of 13
CG42658
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 10 )
Allele
Disease
Evidence
References
Vap33T48I.UAS
model of  amyotrophic lateral sclerosis
CEA
(Chen et al., 2010)
Vap33Δ166
model of  amyotrophic lateral sclerosis type 8
CEA
(Thulasidharan et al., 2024)
CEA with Vap33ALS8
(Thulasidharan et al., 2024)
CEA with Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
Vap33Δ20
model of  amyotrophic lateral sclerosis type 8
CEA
(Mao et al., 2019)
model of  autosomal dominant adult-onset proximal spinal muscular atrophy
CEA
(Mao et al., 2019)
Vap33UAS.cPa
model of  neurodegenerative disease
CEA
(Sanhueza et al., 2014)
model of  amyotrophic lateral sclerosis type 8
CEA
(Beaver et al., 2020)
Vap33P58S.cRa.UAS
model of  amyotrophic lateral sclerosis
CEA
(Ratnaparkhi et al., 2008)
CEC
(Deivasigamani et al., 2014)
model of  amyotrophic lateral sclerosis type 8
CEA
(Chaplot et al., 2019)
CEA with Vap33Δ166
(Tendulkar et al., 2022)
Vap33P58S.UAS.Tag:FLAG
model of  amyotrophic lateral sclerosis
CEA
(Forrest et al., 2013)
model of  amyotrophic lateral sclerosis type 8
CEA
(Kline et al., 2017, Sanhueza et al., 2015)
Vap33P58S.UAS
model of  amyotrophic lateral sclerosis
CEA
(Tsuda et al., 2008)
model of  motor neuron disease
CEA
(Chai et al., 2008)
model of  amyotrophic lateral sclerosis type 8
CEA
(Wong et al., 2021)
CEC
(Wong et al., 2021)
Vap33V260I.UAS
model of  neurodegenerative disease
CEA
(Sanhueza et al., 2014)
Vap33Δ31
model of  amyotrophic lateral sclerosis type 8
CEA with Vap33ALS8
(Moustaqim-Barrette et al., 2014)
CEA
(Kamemura et al., 2021, Mao et al., 2019, Moustaqim-Barrette et al., 2014)
model of  autosomal dominant adult-onset proximal spinal muscular atrophy
CEA
(Mao et al., 2019)
Vap33ALS8
model of  amyotrophic lateral sclerosis type 8
CEA with Vap33Δ31
(Moustaqim-Barrette et al., 2014)
CEA
(Thulasidharan et al., 2024, Mao et al., 2019)
CEA with Vap33Δ166
(Thulasidharan et al., 2024)
model of  autosomal dominant adult-onset proximal spinal muscular atrophy
CEA
(Mao et al., 2019)
Potential Models Based on Orthology ( 2 )
Modifiers Based on Experimental Evidence ( 9 )
Allele
Disease
Interaction
References
Vap33Δ20
model of  amyotrophic lateral sclerosis type 8
is ameliorated by Rab52
(Mao et al., 2019)
is ameliorated by Rab7Gal4-KO
(Mao et al., 2019)
model of  autosomal dominant adult-onset proximal spinal muscular atrophy
is ameliorated by Rab52
(Mao et al., 2019)
is ameliorated by Rab7Gal4-KO
(Mao et al., 2019)
Vap33Δ448
ameliorates  tauopathy
modeled by Hsap\MAPTGMR.Ex.PJ
(Karsten et al., 2006)
Vap33UAS.cPa
model of  amyotrophic lateral sclerosis type 8
is ameliorated by Tip60UAS.cUa
(Beaver et al., 2020)
Vap33UAS.cRa
exacerbates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ166, Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
Vap33P58S.cRa.UAS
model of  amyotrophic lateral sclerosis
is ameliorated by mTorHMS00904
(Deivasigamani et al., 2014)
is ameliorated by ND-20NIG.9172R
(Deivasigamani et al., 2014)
is ameliorated by Tsc1UAS.cTa
(Deivasigamani et al., 2014)
is ameliorated by mTorTED.UAS
(Deivasigamani et al., 2014)
is ameliorated by Nup75NIG.5733R
(Deivasigamani et al., 2014)
is ameliorated by ppk30NIG.18110R
(Deivasigamani et al., 2014)
is ameliorated by Atg1UAS.cCa
(Deivasigamani et al., 2014)
is ameliorated by sshNIG.6238R
(Deivasigamani et al., 2014)
is ameliorated by NaPi-TNIG.10207R
(Deivasigamani et al., 2014)
is ameliorated by Ada2bNIG.9638R
(Deivasigamani et al., 2014)
is ameliorated by CG6048NIG.6048R
(Deivasigamani et al., 2014)
is ameliorated by S6kKQ.UAS
(Deivasigamani et al., 2014)
is ameliorated by gigUAS.cTa
(Deivasigamani et al., 2014)
model of  amyotrophic lateral sclerosis type 8
is ameliorated by CatHMS00990
(Chaplot et al., 2019)
is exacerbated by CatUAS.cAa
(Chaplot et al., 2019)
is ameliorated by Sod1GL01016
(Chaplot et al., 2019)
is ameliorated by Sod1JF03321
(Chaplot et al., 2019)
is ameliorated by Sod2JF01989
(Chaplot et al., 2019)
is ameliorated by mTorGL00156
(Chaplot et al., 2019)
is ameliorated by Vap33JF02621
(Chaplot et al., 2019)
Vap33P58S.UAS.Tag:FLAG
model of  amyotrophic lateral sclerosis
is ameliorated by Pi4KIIIαRNAi.UAS.cUa
(Forrest et al., 2013)
is ameliorated by fwdRNAi.UAS.cUa
(Forrest et al., 2013)
model of  amyotrophic lateral sclerosis type 8
is ameliorated by Spc105RG4635
(Sanhueza et al., 2015)
is ameliorated by CG46491GD10091
(Sanhueza et al., 2015)
is ameliorated by 14-3-3ζEY06147
(Sanhueza et al., 2015)
is exacerbated by Vamp7GD4531
(Sanhueza et al., 2015)
is exacerbated by 14-3-3ζGD16467
(Sanhueza et al., 2015)
is ameliorated by CG4896EY01431
(Sanhueza et al., 2015)
is ameliorated by AcslEY07112
(Sanhueza et al., 2015)
is ameliorated by CG8520EY09481
(Sanhueza et al., 2015)
is exacerbated by AcslGD1638
(Sanhueza et al., 2015)
is exacerbated by CG8520GD14805
(Sanhueza et al., 2015)
is ameliorated by Act42AEY05608
(Sanhueza et al., 2015)
is exacerbated by Act42AGD1350
(Sanhueza et al., 2015)
is ameliorated by CG9643EY07345
(Sanhueza et al., 2015)
is ameliorated by Akap200EP2254
(Sanhueza et al., 2015)
is ameliorated by CaBP1GD4938
(Sanhueza et al., 2015)
is ameliorated by AlaRSEY01137b
(Sanhueza et al., 2015)
is ameliorated by Cdk4EY09330
(Sanhueza et al., 2015)
is exacerbated by Atg7GD11671
(Sanhueza et al., 2015)
is ameliorated by CG10492EY10125
(Sanhueza et al., 2015)
is exacerbated by CG10492GD5326
(Sanhueza et al., 2015)
is ameliorated by CG10809G4564
(Sanhueza et al., 2015)
is exacerbated by Hr39GD4462
(Sanhueza et al., 2015)
is ameliorated by IP3K1UY530
(Sanhueza et al., 2015)
is exacerbated by Cdk4GD11525
(Sanhueza et al., 2015)
is ameliorated by Mef2GD5039
(Sanhueza et al., 2015)
is exacerbated by CG10809GD7097
(Sanhueza et al., 2015)
is ameliorated by CharonEY18569
(Sanhueza et al., 2015)
is ameliorated by CG11125G18969
(Sanhueza et al., 2015)
is ameliorated by OraiEY01467
(Sanhueza et al., 2015)
is ameliorated by Cul2EY09124
(Sanhueza et al., 2015)
is exacerbated by CG11125GD7205
(Sanhueza et al., 2015)
is ameliorated by CG12299EY01579
(Sanhueza et al., 2015)
is exacerbated by CycBGD10993
(Sanhueza et al., 2015)
is exacerbated by CG12299KK110913
(Sanhueza et al., 2015)
is ameliorated by PclEY08457
(Sanhueza et al., 2015)
is ameliorated by Dap160EP2543
(Sanhueza et al., 2015)
is ameliorated by PclGE15295
(Sanhueza et al., 2015)
is ameliorated by CG13192EY07746
(Sanhueza et al., 2015)
is ameliorated by Diap2G2326
(Sanhueza et al., 2015)
is exacerbated by CG13192GD7958
(Sanhueza et al., 2015)
is exacerbated by l(2)k05819GD521
(Sanhueza et al., 2015)
is ameliorated by CG13204EY11838
(Sanhueza et al., 2015)
is exacerbated by Prosβ5GD7568
(Sanhueza et al., 2015)
is exacerbated by Rab32KK107695
(Sanhueza et al., 2015)
is ameliorated by Diap2UAS.cUa
(Sanhueza et al., 2015)
is ameliorated by Rab5EY10619
(Sanhueza et al., 2015)
is exacerbated by CG13204JF02209
(Sanhueza et al., 2015)
is ameliorated by EP3104EP3104
(Sanhueza et al., 2015)
is ameliorated by CG18870EY06926
(Sanhueza et al., 2015)
is exacerbated by Rab5HMS00147
(Sanhueza et al., 2015)
is ameliorated by EnoEY23161
(Sanhueza et al., 2015)
is ameliorated by RapGAP1EY01137a
(Sanhueza et al., 2015)
is exacerbated by RapGAP1LA00889
(Sanhueza et al., 2015)
is ameliorated by RicG2693
(Sanhueza et al., 2015)
is ameliorated by RicUAS.cUa
(Sanhueza et al., 2015)
is exacerbated by CG18870GD2129
(Sanhueza et al., 2015)
is ameliorated by CG3625EY07089
(Sanhueza et al., 2015)
is exacerbated by CG3625GD780
(Sanhueza et al., 2015)
is ameliorated by CG4502EY07938
(Sanhueza et al., 2015)
is ameliorated by Ero1LG18511
(Sanhueza et al., 2015)
is ameliorated by Sec6EY10058
(Sanhueza et al., 2015)
is ameliorated by SgtEY02712
(Sanhueza et al., 2015)
is exacerbated by Ero1LGD3577
(Sanhueza et al., 2015)
is exacerbated by SgtGD11532
(Sanhueza et al., 2015)
is ameliorated by Fs(2)KetEY06666
(Sanhueza et al., 2015)
is ameliorated by Sirt1EP2300
(Sanhueza et al., 2015)
is exacerbated by Upf3GD7228
(Sanhueza et al., 2015)
is ameliorated by HSPC300G19021
(Sanhueza et al., 2015)
is ameliorated by Vamp7G7738
(Sanhueza et al., 2015)
is ameliorated by Sirt1UAS.cUa
(Sanhueza et al., 2015)
is ameliorated by HSPC300HMS01465
(Sanhueza et al., 2015)
is ameliorated by Snx17EY05560
(Sanhueza et al., 2015)
is ameliorated by Herc4GD2240
(Sanhueza et al., 2015)
is ameliorated by Vps35EY14200
(Sanhueza et al., 2015)
is exacerbated by Snx17GD11752
(Sanhueza et al., 2015)
is ameliorated by Hr39EY04579
(Sanhueza et al., 2015)
is exacerbated by Spc105RGL00392
(Sanhueza et al., 2015)
is exacerbated by Vps35GD11710
(Sanhueza et al., 2015)
is ameliorated by abEY09709
(Sanhueza et al., 2015)
is ameliorated by smGD12545
(Sanhueza et al., 2015)
is ameliorated by auxG6787
(Sanhueza et al., 2015)
is ameliorated by cosEY08735
(Sanhueza et al., 2015)
is exacerbated by cosk16101
(Sanhueza et al., 2015)
is ameliorated by crqEY14489
(Sanhueza et al., 2015)
is exacerbated by crqGD784
(Sanhueza et al., 2015)
is ameliorated by dockGD4034
(Sanhueza et al., 2015)
is ameliorated by dpaEY04015
(Sanhueza et al., 2015)
is exacerbated by dpaGD4445
(Sanhueza et al., 2015)
is ameliorated by drprUAS.cUa
(Sanhueza et al., 2015)
is ameliorated by fipiEY20668
(Sanhueza et al., 2015)
is ameliorated by hpoG3315
(Sanhueza et al., 2015)
is ameliorated by hpoJF02740
(Sanhueza et al., 2015)
is ameliorated by SppG2086
(Sanhueza et al., 2015)
is exacerbated by SppGD786
(Sanhueza et al., 2015)
is exacerbated by Src42AGD8338
(Sanhueza et al., 2015)
is ameliorated by Su(var)2-10EY01453
(Sanhueza et al., 2015)
is exacerbated by Su(var)2-10GD5048
(Sanhueza et al., 2015)
is ameliorated by SwimEY09931
(Sanhueza et al., 2015)
is exacerbated by SwimGD2147
(Sanhueza et al., 2015)
is ameliorated by Syx6EY14508
(Sanhueza et al., 2015)
is ameliorated by Syx7G6457
(Sanhueza et al., 2015)
is ameliorated by T3dhEY09338
(Sanhueza et al., 2015)
is exacerbated by T3dhMB09825
(Sanhueza et al., 2015)
is ameliorated by Trap1EY10238
(Sanhueza et al., 2015)
is ameliorated by Upf3EY03241
(Sanhueza et al., 2015)
is exacerbated by hrgGD14701
(Sanhueza et al., 2015)
is ameliorated by spagEY11196
(Sanhueza et al., 2015)
is exacerbated by kisGD16331
(Sanhueza et al., 2015)
is ameliorated by tejEY20088
(Sanhueza et al., 2015)
is ameliorated by klarYG3
(Sanhueza et al., 2015)
is ameliorated by l(2)k05819EY03384
(Sanhueza et al., 2015)
is exacerbated by miltGD8116
(Sanhueza et al., 2015)
is ameliorated by miltLA00951
(Sanhueza et al., 2015)
is ameliorated by qkr58E-3EY02038
(Sanhueza et al., 2015)
is exacerbated by qkr58E-3GD11020
(Sanhueza et al., 2015)
is ameliorated by rdgBβEP2360
(Sanhueza et al., 2015)
is ameliorated by rdgBβG8057
(Sanhueza et al., 2015)
is ameliorated by rhoEP3704
(Sanhueza et al., 2015)
is ameliorated by rhoUAS.cUa
(Sanhueza et al., 2015)
is ameliorated by robo2EP2582
(Sanhueza et al., 2015)
is exacerbated by robo2GD109
(Sanhueza et al., 2015)
is ameliorated by scaGD1965
(Sanhueza et al., 2015)
is ameliorated by DfdGD16159
(Kline et al., 2017)
Vap33JF02621
ameliorates  amyotrophic lateral sclerosis type 8
modeled by Vap33P58S.cRa.UAS
(Chaplot et al., 2019)
modeled by Vap33Δ166, Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
exacerbates  amyotrophic lateral sclerosis type 8
modeled by Vap33Δ166, Vap33P58S.cRa.UAS
(Tendulkar et al., 2022)
Vap33P58S.UAS
model of  amyotrophic lateral sclerosis type 8
is ameliorated by ItprJF01957
(Wong et al., 2021)
is ameliorated by mAChR-AHMC02343
(Wong et al., 2021)
is ameliorated by norpAunspecified
(Wong et al., 2021)
Vap33Δ31
model of  amyotrophic lateral sclerosis type 8
is ameliorated by Hsap\VAPBP56S.UAS.cTa
(Kamemura et al., 2021)
is ameliorated by Hsap\VAPBUAS.cCa
(Kamemura et al., 2021)
Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
VAPB; VAMP associated protein B and C
13 of 14
VAMP-ASSOCIATED PROTEIN B AND C; VAPB
 
VAPA; VAMP associated protein A
12 of 14
605703
      Functional Complementation Data
      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
      Dmel gene
      Ortholog showing functional complementation
      Supporting References
      Vap33
      Hsap\VAPB
      (Kamemura et al., 2021, Chai et al., 2008)
      Interactions
      Summary of Physical Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please see the Physical Interaction reports below for full details
      protein-protein
      Physical Interaction
      Assay
      References
      Vap33 - Acbp7
      anti tag coimmunoprecipitation, anti tag western blot
      (Kors et al., 2024)
      Vap33 - Agpat3
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - CG13220
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - CG1513
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - CG33523
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - CG5742
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - CG8765
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - CG9205
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - Dscam1
      anti bait coimmunoprecipitation, western blot, pull down, anti tag coimmunoprecipitation, peptide massfingerprinting
      (Yang et al., 2012)
      Vap33 - Git
      proximity ligation assay, fluorescence microscopy, anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Portela et al., 2024)
      Vap33 - Lfg
      two hybrid
      (Hu et al., 2017.6.13)
      Vap33 - MRG15
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - Miga
      anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry
      (Xu et al., 2022, Xu et al., 2020)
      Vap33 - Nemp
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - Osbp
      pull down, western blot
      (Moustaqim-Barrette et al., 2014)
      Vap33 - Pcyt2
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - Rdh1
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - ReepA
      experimental knowledge based
      (Guruharsha et al., 2011)
      Vap33 - Sac1
      anti tag coimmunoprecipitation, anti tag western blot, two hybrid
      (Forrest et al., 2013)
      Vap33 - Vha44
      proximity ligation assay, fluorescence microscopy
      (Portela et al., 2018)
      Vap33 - Vha68-2
      anti tag coimmunoprecipitation, anti tag western blot
      (Portela et al., 2018)
      Vap33 - Vha68-3
      anti tag coimmunoprecipitation, anti tag western blot
      (Portela et al., 2018)
      Vap33 - casp
      anti bait coimmunoprecipitation, western blot, Identification by mass spectrometry, anti tag coimmunoprecipitation, anti tag western blot
      (Tendulkar et al., 2022)
      Vap33 - dachs
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Vap33 - ft
      anti tag coimmunoprecipitation, peptide massfingerprinting
      (Kwon et al., 2013)
      Vap33 - hpo
      anti tag coimmunoprecipitation, anti tag western blot
      (Portela et al., 2024)
      Vap33 - kek6
      anti tag coimmunoprecipitation, anti tag western blot
      (Ulian-Benitez et al., 2017)
      Vap33 - l(2)gl
      anti tag coimmunoprecipitation, anti tag western blot, proximity ligation assay, fluorescence microscopy, pull down, Identification by mass spectrometry
      (Portela et al., 2024, Portela et al., 2018)
      Vap33 - pix
      anti tag coimmunoprecipitation, anti tag western blot, Identification by mass spectrometry
      (Portela et al., 2024)
      Vap33 - rdgB
      anti bait coimmunoprecipitation, western blot
      (Krishnan et al., 2023)
      Vap33 - rictor
      anti tag coimmunoprecipitation, Identification by mass spectrometry
      (Vinayagam et al., 2016)
      Summary of Genetic Interactions
      Interaction Browsers
      View in FlyBase Interactions Browser   View in MIST tool (external link)
      Please look at the allele data for full details of the genetic interactions
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      Vap33
      suppressible
      Ada2b
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      Atg1
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      CG6048
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      CG7564
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      Eph
      (Tsuda et al., 2008)
      Vap33
      suppressible
      fwd
      (Forrest et al., 2013)
      Vap33
      suppressible
      mTor
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      NaPi-T
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      ND-20
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      Nup75
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      Pi4KIIIα
      (Forrest et al., 2013)
      Vap33
      suppressible
      ppk30
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      S6k
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      Sod1
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      ssh
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      TBPH
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      Thor
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      tkv
      (Ratnaparkhi et al., 2008)
      Vap33
      suppressible
      Tsc1
      (Deivasigamani et al., 2014)
      Vap33
      suppressible
      Tsc1|gig
      (Deivasigamani et al., 2014)
      Starting gene(s)
      Interaction type
      Interacting gene(s)
      Reference
      kek6
      suppressible
      Vap33
      (Ulian-Benitez et al., 2017)
      Osbp
      suppressible
      Vap33
      (Ma et al., 2010)
      spz5
      suppressible
      Vap33
      (Ulian-Benitez et al., 2017)
      spz5|kek6
      enhanceable
      Vap33
      (Ulian-Benitez et al., 2017)
      spz5|kek6
      suppressible
      Vap33
      (Ulian-Benitez et al., 2017)
      αCOP
      suppressible
      Vap33
      (Maddison et al., 2023)
      External Data
      Linkouts
      BioGRID - A database of protein and genetic interactions.
      DroID - A comprehensive database of gene and protein interactions.
      MIST (genetic) - An integrated Molecular Interaction Database
      MIST (protein-protein) - An integrated Molecular Interaction Database
      Pathways
      Signaling Pathways (FlyBase)
      Metabolic Pathways
      FlyBase
      External Links
      Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
      External Data
      Class of Gene
      Genomic Location and Detailed Mapping Data
      Chromosome (arm)
      X
      Recombination map
      1-5
      Cytogenetic map
      3F9-3F9
      Sequence location
      FlyBase Computed Cytological Location
      Cytogenetic map
      Evidence for location
      3F9-3F9
      Limits computationally determined from genome sequence between P{EP}CG2930EP1352 and P{EP}EP425
      Experimentally Determined Cytological Location
      Cytogenetic map
      Notes
      References
      3F-3F
      (determined by in situ hybridisation)
      (Peter et al., 2002, Schäfer et al., 1999.12.2)
      3F5-3F6
      (determined by in situ hybridisation)
      (Pennetta et al., 2002)
      Experimentally Determined Recombination Data
      Location

      1-5

      (FlyBase, 2016)

      1-5.3

      (Comeron et al., 2012)
      Left of (cM)
      Right of (cM)
      Notes
      Stocks and Reagents
      Stocks (15)
      Genomic Clones (10)
       

      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

      cDNA Clones (221)
       

      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

      cDNA clones, fully sequenced
      BDGP DGC clones
      Other clones
      Drosophila Genomics Resource Center cDNA clones

      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

      cDNA Clones, End Sequenced (ESTs)
      BDGP DGC clones
      Other clones
      RNAi and Array Information
      Linkouts
      DRSC - Results frm RNAi screens
      Antibody Information
      Laboratory Generated Antibodies
       

      polyclonal

      (Yadav et al., 2018, Tsuda et al., 2008)
      Commercially Available Antibodies
       
      Cell Line Information
      Publicly Available Cell Lines
       
        Other Stable Cell Lines
         
        Other Comments

        Hypomorphic and null mutations in Vap-33-1 cause a severe decrease in bouton number and an increase in bouton size.

        (Chai et al., 2008)

        dsRNA made from templates generated with primers directed against this gene tested in RNAi screen for effects on Kc167 and S2R+ cell morphology.

        (Kiger et al., 2003)

        Vap-33-1 and dlg1 localize asymmetrically at the synapse during bouton budding.

        (Pennetta et al., 2002)
        Relationship to Other Genes
        Source for database merge of

        Source for merge of: Vap-33-1 l(1)G0231

        (Peter et al., 2002)

        Source for merge of: Vap-33-1 anon- EST:Liang-2.42

        (Ashburner, 2004.6.30)

        Source for merge of: Vap-33-1 BcDNA:GM03307

        (FlyBase, 1996-)

        Source for merge of: Vap-33-1 anon-WO03040301.124

        (FlyBase, 1996-)
        Additional comments

        Source for merge of Vap-33-1 BcDNA:GM03307 was a shared cDNA ( date:030728 ).

        (FlyBase, 1996-)

        Source for merge of Vap-33-1 anon-WO03040301.124 was sequence comparison ( date:051113 ).

        (FlyBase, 1996-)
        Nomenclature History
        Source for database identify of

        Source for identity of: Vap-33-1 CG5014

        (Verstreken and Bellen, 2000.9.4)

        Source for identity of: Vap-33A Vap-33-1

        (Pennetta et al., 2002)

        Source for identity of: Vap33 Vap-33A

        (Pennetta, 2016.5.9)
        Nomenclature comments

        Symbol of this gene changed from 'Vap-33A' to 'Vap33' as it is now apparent that it encodes the sole VAP protein in D. melanogaster. (FlyBase curator comment: The '33' suffix has been retained to distinguish this gene from the 'vap' gene (FBgn0003969)).

        (Pennetta, 2016.5.9)

        FlyBase curator comment: Originally called 'VAP-33-1' in FBrf0127207, but papers by same group (this one & FBrf0202930) call it 'VAP-33A'. (This nomenclature also matches the related gene named 'VAP-33B'.)

        (Pennetta et al., 2002)
        Etymology
        Synonyms and Secondary IDs (34)
        Reported As
        Symbol Synonym
        BcDNA:GM03307
        CG5014
        (Kors et al., 2024, Kolkhof et al., 2017, Cockcroft and Raghu, 2016, Hosono et al., 2015, Rosa-Ferreira et al., 2015, White-Grindley et al., 2014, Krahmer et al., 2013, Jaspers et al., 2012, Cammarato et al., 2011, Müller et al., 2010, Keleman et al., 2009.8.5, Pan and Zhang, 2009, Perkins et al., 2009, Chai et al., 2008, Cermelli et al., 2006, Legube et al., 2006, Ashburner, 2004.6.30, Whitfield et al., 2002)
        DVAP
        (Kline et al., 2017, Pennetta, 2016.5.9, Sanhueza et al., 2015, Sanhueza et al., 2014, Forrest et al., 2013, Chen et al., 2010)
        DVAP-33A
        (Chen et al., 2010, Lorbeck et al., 2010, Chai et al., 2008, Pennetta et al., 2003, Verstreken et al., 2003, Pennetta et al., 2002)
        DVAP33A
        (Karsten et al., 2006)
        VAP
        (Thulasidharan et al., 2024, Tendulkar et al., 2022, Chaplot et al., 2019, Ryoo, 2015, Deivasigamani et al., 2014, Beck et al., 2012, Han et al., 2012, Ratnaparkhi et al., 2008)
        VAP-33
        (Babcock et al., 2004)
        VAP-33-1
        (Kline et al., 2017, Lloyd et al., 2000)
        VAP33
        (Gaspar et al., 2022, Lloyd and Taylor, 2010)
        VAP33-A
        (Tsuda et al., 2008)
        VAP33A
        (Chaplot et al., 2019, Ulian-Benitez et al., 2017)
        VAPB
        (Ratnaparkhi et al., 2008, Karsten et al., 2006)
        Vap-33-1
        (Titlow et al., 2023, Beaver et al., 2020, Kitatani et al., 2020, Mukherjee et al., 2020, Aw et al., 2017, Ashwal-Fluss et al., 2014, Cao et al., 2014, Chen et al., 2014, Moustaqim-Barrette et al., 2014, White-Grindley et al., 2014, Krahmer et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Kwon et al., 2013, Japanese National Institute of Genetics, 2012.5.21, Bayat et al., 2011, Friedman et al., 2011, Lorbeck et al., 2010, Ma et al., 2010, Müller et al., 2010, Berkey et al., 2009, Liu et al., 2009, Parks and Muskavitch, 2009.2.2, Perkins et al., 2009.8.10, Tan et al., 2009, Beckstead et al., 2007, Cermelli et al., 2006)
        Vap-33A
        (Dalton et al., 2022, Goyal et al., 2019, Sanhueza et al., 2014)
        Vap33
        (Crane et al., 2025, Portela et al., 2024, Liu et al., 2023, Maddison et al., 2023, O'Brien et al., 2023, Byrne et al., 2022, Ecovoiu et al., 2022, Xu et al., 2022, Baker et al., 2021, Uçkun et al., 2021, Yamaguchi et al., 2021, Bolus et al., 2020, Xu et al., 2020, Goyal et al., 2019, Mao et al., 2019, Azuma et al., 2018, Portela et al., 2018, Zhang et al., 2018, Hu et al., 2017.6.13, Transgenic RNAi Project members, 2017-, Sopko and Perrimon, 2013)
        Vap33-1
        (Huang et al., 2007)
        anon-EST:Liang-2.42
        anon-WO03040301.124
        clone 2.42
        (Liang and Biggin, 1998)
        dVAP
        (Casci and Pandey, 2015, Tsuda et al., 2008)
        dVAP-33
        (Hegde and Srivastava, 2022)
        dVAP-A
        (Krishnan et al., 2023, Raghu et al., 2021, Smylla et al., 2021, Yadav et al., 2018, Cockcroft and Raghu, 2016)
        dVAP33A
        (Braems et al., 2021, Ratnaparkhi et al., 2008, Ratnaparkhi et al., 2008, Karsten et al., 2006)
        dVap-A
        (Kors et al., 2024)
        dvap
        (Han et al., 2012)
        dvap33a
        (Ma et al., 2010)
        l(1)G0231
        (Schäfer et al., 1999.12.2)
        vap-33A
        (Roman, 2004)
        vap33
        (Kamemura et al., 2021)
        vap33-1
        (Buscaino et al., 2006)
        vapb
        (Karagas et al., 2022, Wong et al., 2021)
        Name Synonyms
        VAMP-associated protein 33kDa
        VAMP-associated protein of 33kDa A
        (Chai et al., 2008)
        VAMP-associated protein of 33kDa ortholog A
        Vap-33-1
        (Jaspers et al., 2012, Cammarato et al., 2011)
        Vap33-1
        (Huang et al., 2007)
        Secondary FlyBase IDs
        • FBgn0025953
        • FBgn0040184
        • FBgn0062492
        • FBgn0066853
        Datasets (0)
        Study focus (0)
        Experimental Role
        Project
        Project Type
        Title
        Study result (0)
        Result
        Result Type
        Title
        External Crossreferences and Linkouts ( 63 )
        Sequence Crossreferences
        NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
        GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
        GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
        RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
        UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
        UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
        Other crossreferences
        AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
        BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
        DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
        EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
        FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
        FlyMine - An integrated database for Drosophila genomics
        InterPro - A database of protein families, domains and functional sites
        KEGG Genes - Molecular building blocks of life in the genomic space.
        MARRVEL_MODEL - MARRVEL (model organism gene)
        Linkouts
        BioGRID - A database of protein and genetic interactions.
        Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
        DroID - A comprehensive database of gene and protein interactions.
        DRSC - Results frm RNAi screens
        Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
        FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
        FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
        Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
        Flygut - An atlas of the Drosophila adult midgut
        FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
        iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
        Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
        MIST (genetic) - An integrated Molecular Interaction Database
        MIST (protein-protein) - An integrated Molecular Interaction Database
        Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
        Reactome Metabolic Pathways - An open-source, open access, manually curated and peer-reviewed metabolic pathway database.
        References (162)