FlyBase Allele Report: Dmel\mTor[GL00156]

General Information

Symbol

Dmel\mTor^GL00156

Species

D. melanogaster

Name

FlyBase ID

FBal0262633

Feature type

allele

Associated gene

Dmel\mTor

Associated Insertion(s)

Carried in Construct

P{TRiP.GL00156}

Also Known As

UAS-TOR RNAi, GL00156, UAS-Tor-shRNA, UAS-IR-TOR^GL00156

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.GL00156}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-GL00156

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates prostate cancer

modeled by Ras85D^V12.UAS

(Rambur et al., 2020)

ameliorates amyotrophic lateral sclerosis type 8

modeled by Vap33^P58S.cRa.UAS

(Chaplot et al., 2019)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

Expressing Tor^GL00156 under the control of Scer\GAL4^en.PU leads to more cells undergoing S-phase and mitosis in the posterior compartment of the wing disc (where Scer\GAL4^en.PU is driving expression), despite a significant decrease in wing compartment size, as compared to controls.

(Li et al., 2019)

Expression of Tor^GL00156 under the control of Scer\GAL4^{Myo31DF-NP0001} results in premature autophagy in the larval midgut and shortened gastric caeca at an early age, 4 hrs before puparium formation.

Expression of Tor^GL00156 under the control of Scer\GAL4^cg.PU results in a lack of autophagic difference in the larval fat body between fed and starved flies as compared to controls.

(Xu et al., 2015)

Females heterozygous for Tor^GL00156 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Tor^GL00156 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.

(Sopko et al., 2014)

Scer\GAL4^He.PZ-mediated expression of Tor^GL00156 markedly downregulates hemocyte counts in larvae.

(Tran et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

mTor^GL00156/Scer\GAL4^en-e16E is a suppressor | partially of increased cell death | third instar larval stage phenotype of Scer\GAL4^en-e16E, vtd^GL00522

(Liu et al., 2016)

Phenotype Manifest In

Suppressor of

Statement

Reference

mTor^GL00156/Scer\GAL4^en-e16E is a suppressor of wing disc | third instar larval stage phenotype of Scer\GAL4^en-e16E, vtd^GL00522

(Liu et al., 2016)

mTor^GL00156/Scer\GAL4^en-e16E is a suppressor | partially of chromosome | third instar larval stage phenotype of Scer\GAL4^en-e16E, vtd^GL00522

(Liu et al., 2016)

NOT Suppressor of

Statement

Reference

mTor^GL00156/Scer\GAL4^Mhc.PK is a non-suppressor of mesothoracic tergotrochanter muscle cell | progressive phenotype of HDAC6^KO

(Yan et al., 2017)

mTor^GL00156/Scer\GAL4^Mhc.PK is a non-suppressor of lipid droplet | adult stage | progressive phenotype of HDAC6^KO

(Yan et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

The dramatic increase in apoptosis (visualized by [*]Casp3 or acridine orange staining) along with the elevated oxidative stress (monitored by levels of ROS) and increased frequency of aneuploid metaphases observed in larval wing discs upon expression of vtd^GL00522 driven by Scer\GAL4^en-e16E can be suppressed by co-expression of Tor^GL00156.

(Liu et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

35578