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General Information
Symbol
Dmel\klarYG3
Species
D. melanogaster
Name
FlyBase ID
FBal0194848
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Cytology
Nature of the lesion
Statement
Reference

Imprecise excision of the P{EP} element, resulting in an ~11kb deletion around exon 0.

Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

At 25[o]C the fraction and net velocity vector of motile osk ribonucleoproteins (RNPs) in homozygous or klarYG3/klar1 oocytes is not significantly different from wild type. However the mean speed is slightly, but significantly reduced and RNP travel distance is significantly increased. At 18[o]C, the fraction of motile osk RNPs in the mutant oocytes is double that seen in control oocytes in a given imaging period. The RNP travel distance is significantly increased compared to wild type at this temperature.

The hatching rate of embryos derived from homozygous females is reduced compared to those derived from wild-type females, at both 25[o]C and 18[o]C (the phenotype is more severe at 18[o]C). Many embryos laid by homozygous females are arrested before the syncytial blastoderm stage or have abnormal nuclear distribution around cellularisation. Most unhatched embryos fail to form a cuticle and those that do, show defects in overall patterning.

The nuclei of developing photoreceptor cells are mispositioned in mutant eye imaginal discs, with many nuclei being found basally (the nuclei are apical in wild-type discs).

In klarYG3 mutant eye discs, nuclei are present in both apical and basal sections, indicating disrupted nuclear migration; nuclei are also found in the optical nerve.

klarYG3 embryos show aberrant lipid droplet transport.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressed by
Statement
Reference
Phenotype Manifest In
Additional Comments
Genetic Interactions
Statement
Reference

The alterations in osk ribonucleoprotein motility which are seen in homozygous klarYG3 oocytes are partially suppressed if the females are also carrying either Khc17/+ or Pat1robin/Pat1robin.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Name Synonyms
Secondary FlyBase IDs
    References (5)