FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\norpAunspecified
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General Information
Symbol
Dmel\norpAunspecified
Species
D. melanogaster
Name
FlyBase ID
FBal0062526
Feature type
allele
Associated gene
Dmel\norpA
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
    Nature of the Allele
    Allele class
    Mutagen
    Progenitor genotype
    Cytology
    Description

    FlyBase curator comment: this entry is used to capture phenotypic information when the particular allele (or allele combination) used by the author could not be determined but the context of the experiment suggests that the phenotype being described is some kind of loss of function.

    (FlyBase Curators, 2025-)
    Mutations Mapped to the Genome
    Curation Data
    Type
    Location
    Additional Notes
    References
    Variant Molecular Consequences
    Associated Sequence Data
    DDBJ / EMBL / GenBank
    DNA sequence
    Protein sequence
     
    UniProtKB/Swiss-Prot
      UniProtKB/TrEMBL
        Expression Data
        Reporter Expression
        Additional Information
        Statement
        Reference
         
        Marker for
        Reflects expression of
        Reporter construct used in assay
        Human Disease Associations
        Disease Ontology (DO) Annotations
        Models Based on Experimental Evidence ( 0 )
        Disease
        Evidence
        References
        Modifiers Based on Experimental Evidence ( 1 )
        Disease
        Interaction
        References
        ameliorates  tauopathy
        modeled by Hsap\MAPTUAS.cAa
        (Wong et al., 2021)
        ameliorates  amyotrophic lateral sclerosis type 8
        modeled by Vap33P58S.UAS
        (Wong et al., 2021)
        Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
         
        Disease-implicated variant(s)
         
        Phenotypic Data
        Phenotypic Class
        Phenotype Manifest In
        Detailed Description
        Statement
        Reference

        Cad99C-dependent endosome formation is abolished in norpAunspecified mutants.

        (Lee et al., 2015)

        The number of successful climbs by norpAunspecified flies when crossing gaps of 1-4mm is greatly reduced compared to wild-type flies. norpAunspecified flies occasionally show "leg-over-head" behaviour indicative of a climbing attempt, but do not direct their leg movements to the opposing side of the gap.

        (Pick and Strauss, 2005)
        External Data
        Interactions
        Show genetic interaction network for Enhancers & Suppressors
        Phenotypic Class
        Phenotype Manifest In
        Additional Comments
        Genetic Interactions
        Statement
        Reference
        Xenogenetic Interactions
        Statement
        Reference
        Complementation and Rescue Data
        Partially rescued by

        norpAunspecified is partially rescued by norpAninaE.PM

        (Wernet et al., 2012)

        norpAunspecified is partially rescued by norpAUAS.cWa/Scer\GAL4Rh3.PP

        (Wernet et al., 2012)

        norpAunspecified is partially rescued by Scer\GAL4Rh6+DRA/norpAUAS.cWa

        (Wernet et al., 2012)

        norpAunspecified is partially rescued by Scer\GAL4Rh5.PT/norpAUAS.cWa

        (Wernet et al., 2012)

        norpAunspecified is partially rescued by norpAUAS.cWa/Scer\GAL4Rh6.PD

        (Wernet et al., 2012)
        Not rescued by

        norpAunspecified is not rescued by norpAUAS.cWa/Scer\GAL4Rh2.PB

        (Wernet et al., 2012)

        norpAunspecified is not rescued by norpAUAS.cWa/Scer\GAL4Rh4.PT

        (Wernet et al., 2012)

        norpAunspecified is not rescued by norpAUAS.cWa/Scer\GAL4hth-GAL4

        (Wernet et al., 2012)
        Comments

        Expression of norpAScer\UAS.cWa under the control of either Scer\GAL4Rh3.PP or Scer\GAL4Rh6+DRA in norpAunspecified flies rescues a polarotactic response to linearly polarised UV light presented dorsally.

        Expression of norpAScer\UAS.cWa under the control of any one of Scer\GAL4Rh2.PB, Scer\GAL4Rh4.PT, Scer\GAL4Rh5.PT, Scer\GAL4Rh6.PD or Scer\GAL4hth-GAL4 in norpAunspecified flies does not rescue a polarotactic response to linearly polarised UV light presented dorsally.

        Expression of norpAScer\UAS.cWa under the control of either Scer\GAL4Rh3.PP or Scer\GAL4Rh5.PT in norpAunspecified flies weakly rescues a polarotactic response to linearly polarised UV light presented ventrally.

        Expression of norpAScer\UAS.cWa under the control of either Scer\GAL4hth-GAL4 or Scer\GAL4Rh6+DRA in norpAunspecified flies fails to rescue a polarotactic response to linearly polarised UV light presented ventrally.

        Expression of norpAScer\UAS.cWa under the simultaneous control of both Scer\GAL4ninaE.PT and Scer\GAL4Rh3.PP in norpAunspecified flies rescues to wild type the polarotactic response to linearly polarised UV light presented ventrally.

        Expression of norpAScer\UAS.cWa under the control of either Scer\GAL4Rh5.PT or Scer\GAL4Rh6.PD in norpAunspecified flies rescues a polarotactic response to linearly polarised green light presented ventrally.

        norpAninaE.PM fails to rescue a polarotactic response to linearly polarised UV light presented dorsally in norpAunspecified flies.

        norpAninaE.PM weakly rescues a polarotactic response to linearly polarised UV light presented ventrally in norpAunspecified flies.

        norpAninaE.PM rescues a polarotactic response to linearly polarised green light presented ventrally in norpAunspecified flies.

        (Wernet et al., 2012)
        Images (0)
        Mutant
        Wild-type
        Stocks (0)
        Notes on Origin
        Discoverer
        External Crossreferences and Linkouts ( 0 )
        Synonyms and Secondary IDs (2)
        Reported As
        Symbol Synonym
        norpAunspecified
        unspecified
        (Johnson et al., 1997)
        Name Synonyms
        Secondary FlyBase IDs
          References (9)