FlyBase Gene Report: Dmel\Ada2b

(Fisher et al., 2012)

embryonic stage 7 -- 8

(Fisher et al., 2012)

embryonic stage 9 -- 10

(Fisher et al., 2012)

embryonic stage 11 -- 12

View Dmel\Ada2b in GBrowse 2

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic brain

(Fisher et al., 2012)

embryonic/larval midgut

(Fisher et al., 2012)

ventral nerve cord

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

western blot

Stage

Tissue/Position (including subcellular localization)

Reference

pupal stage

organism

(Zsindely et al., 2009)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

part_of H3 histone acetyltransferase complex

inferred from direct assay

(Torres-Zelada et al., 2019)

located_in nucleus

inferred from direct assay

(assigned by UniProt )

(Muratoglu et al., 2003)

inferred from direct assay

(Weake et al., 2011, Guelman et al., 2006)

located_in polytene chromosome

inferred from direct assay

(Nagy et al., 2010, Kusch et al., 2003, Muratoglu et al., 2003)

part_of SAGA complex

inferred from physical interaction with FLYBASE:Spt3; FB:FBgn0037981

(Kusch et al., 2003)

inferred from physical interaction with FLYBASE:Nipped-A; FB:FBgn0053554

(Kusch et al., 2003)

inferred from direct assay

(Torres-Zelada et al., 2019, Weake et al., 2011, Guelman et al., 2006)

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

GBrowse - Visual display of RNA-Seq signals

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\Ada2b

View exonic expression by tissue for Dmel\Ada2b

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0037555

FLIGHT - Cell culture data for RNAi and other high-throughput technologies

FBgn0037555

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

CG9638-RA

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG9638

Flygut - An atlas of the Drosophila adult midgut

FBgn0037555

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, and Transgenic Constructs

Classical and Insertion Alleles ( 9 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 22 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of Ada2b

Transgenic constructs containing regulatory region of Ada2b

Deletions and Duplications ( 2 )

Disrupted in

Df(3R)Ada2b^d52

(Pankotai et al., 2005)

Df(3R)dsx5

(Qi et al., 2004)

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal (with Ada2b¹)

Ada2b^d842

lethal (with Ada2b^d842)

Ada2b¹

lethal | pharate adult stage

lethal | pharate adult stage (with Df(3R)Ada2b^d52)

lethal | pupal stage P5

lethal | pupal stage P5 (with Df(3R)Ada2b^d52)

lethal - all die before end of pupal stage

Ada2b^d842

lethal - all die before end of pupal stage | recessive

partially lethal - majority die

Ada2b^HD-5

partially lethal - majority die, with Scer\GAL4^pnr-MD237

Ada2b^GD14276

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

Ada2b^GD14276

viable, with Scer\GAL4^Mef2.PR

Ada2b^GD14276

viable, with Scer\GAL4^tin.CΔ4

Ada2b^GD14276

Sterility

Allele

female sterile | germline clone | recessive

fertile, with Ada2b¹/Ada2b^d842

Ada2b^PA

fertile, with Ada2b¹/Ada2b^d842, Ada2b^PA

Ada2b^PB

fertile, with Ada2b¹/Ada2b^d842, Ada2b^PB

Ada2b^PA

fertile (with Ada2b¹), with Ada2b^PA

Ada2b^d842

fertile (with Ada2b¹), with Ada2b^PA, Ada2b^PB

Ada2b^d842

fertile (with Ada2b^d842), with Ada2b^PA

Ada2b¹

fertile (with Ada2b^d842), with Ada2b^PA, Ada2b^PB

Ada2b¹

Other Phenotypes

Allele

neuroanatomy defective

Ada2b¹

some die during pupal stage

Ada2b^d842

some die during pupal stage, with Scer\GAL4^pnr-MD237

Ada2b^GD14276

some die during pupal stage | recessive

visible, with Scer\GAL4^pnr-MD237

Ada2b^GD14276

Phenotype manifest in

Allele

axon & photoreceptor cell R2

Ada2b¹

axon & photoreceptor cell R3

Ada2b¹

axon & photoreceptor cell R4

Ada2b¹

axon & photoreceptor cell R5

Ada2b¹

glial cell

Ada2b¹

trichogen cell, with Scer\GAL4^pnr-MD237

Ada2b^GD14276

wing disc | conditional

Ada2b^unspecified

Orthologs

Downloads

Download All DIOPT Orthologs

Download All OrthoDB Orthologs

Human Orthologs (via DIOPT v8.0)

Homo sapiens (Human) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Hsap\TADA2B

15 of 15

Yes

Hsap\TADA2A

5 of 15

Model Organism Orthologs (via DIOPT v8.0)

Mus musculus (laboratory mouse) (2)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Mmus\Tada2b

12 of 15

Yes

Mmus\Tada2a

5 of 15

Rattus norvegicus (Norway rat) (2)

Rnor\Tada2b

13 of 13

Yes

Rnor\Tada2a

4 of 13

Xenopus tropicalis (Western clawed frog) (2)

Xtro\tada2b

13 of 12

Yes

Xtro\tada2a

4 of 12

Danio rerio (Zebrafish) (2)

Drer\tada2b

14 of 15

Yes

Drer\tada2a

5 of 15

Caenorhabditis elegans (Nematode, roundworm) (2)

Cele\ada-2

9 of 15

Yes

Cele\sqst-5

1 of 15

Arabidopsis thaliana (thale-cress) (3)

Atha\ADA2B

7 of 9

Yes

Atha\ADA2A

6 of 9

Yes

Atha\AT4G09450

1 of 9

Yes

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\ADA2

11 of 15

Yes

Scer\FUN19

1 of 15

Scer\YOR338W

1 of 15

Schizosaccharomyces pombe (Fission yeast) (3)

Spom\ada2

9 of 12

Yes

Spom\laf1

1 of 12

Yes

Spom\laf2

1 of 12

Yes

Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091907YB )

Organism

Common Name

Gene

AAA Syntenic Ortholog

Multiple Dmel Genes in this Orthologous Group

Drosophila suzukii

Spotted wing Drosophila

Drosophila simulans

Drosophila sechellia

Drosophila erecta

Drosophila yakuba

Drosophila ananassae

Drosophila pseudoobscura pseudoobscura

Dpse\GA21933

Drosophila persimilis

Dper\GL23274

Drosophila willistoni

Dwil\GK14452

Drosophila virilis

Dvir\GJ23060

Drosophila mojavensis

Dmoj\GI24281

Drosophila grimshawi

Dgri\GH19246

Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091505FP )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Musca domestica

House fly

Mdoa\17012794

Glossina morsitans

Tsetse fly

Gmor\GMOY004623

Lucilia cuprina

Australian sheep blowfly

Lcup\FF38_08281

Aedes aegypti

Yellow fever mosquito

Aaeg\AAEL002137

Anopheles darlingi

American malaria mosquito

Adar\ADAC001026

Anopheles gambiae

Malaria mosquito

Agam\AGAP003109

Culex quinquefasciatus

Southern house mosquito

Cqui\CPIJ007393

Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W05C1 )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Bombyx mori

Silkmoth

Bmor\BGIBMGA004964

Danaus plexippus

Monarch butterfly

Dple\DPOGS211311-PA

Heliconius melpomene

Postman butterfly

Hmel\HMEL009363

Apis florea

Little honeybee

Aflo\3023099812

Apis mellifera

Western honey bee

Amel\GB52323

Bombus impatiens

Common eastern bumble bee

Bimp\BIMP13723

Bombus terrestris

Buff-tailed bumblebee

Bter\15208741

Linepithema humile

Argentine ant

Lhum\LH23419

Megachile rotundata

Alfalfa leafcutting bee

Mrot\MROTU:002d89

Nasonia vitripennis

Parasitic wasp

Nvit\Nasvi2EG011135

Dendroctonus ponderosae

Mountain pine beetle

Dpod\YQE_03904

Tribolium castaneum

Red flour beetle

Tcas\TC009145

Pediculus humanus

Human body louse

Phum\PHUM333960

Rhodnius prolixus

Kissing bug

Rpro\RPRC003177

Cimex lectularius

Bed bug

Clec\CLEC005708

Acyrthosiphon pisum

Pea aphid

Apim\ACYPI009268

Zootermopsis nevadensis

Nevada dampwood termite

Znev\Znev_10173

Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X058A )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strigamia maritima

European centipede

Smar\SMAR006451

Ixodes scapularis

Black-legged tick

Isca\ISCW008979

Tetranychus urticae

Two-spotted spider mite

Turt\tetur19g00690

Daphnia pulex

Water flea

Dpux\DAPPUDRAFT_227604

Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0CQZ )

Organism

Common Name

Gene

Multiple Dmel Genes in this Orthologous Group

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tk9

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tada2b

Strongylocentrotus purpuratus

Purple sea urchin

Spur\SPU_003252gn

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Ret

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Fgfr

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Tk8

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cret

Strongylocentrotus purpuratus

Purple sea urchin

Spur\Sp-Cret_1

Ciona intestinalis

Vase tunicate

Cint\ENSCING00000001931

Ciona intestinalis

Vase tunicate

Cint\fgfr

Gallus gallus

Domestic chicken

Ggal\RET

Gallus gallus

Domestic chicken

Ggal\FGFR4

Gallus gallus

Domestic chicken

Ggal\FGFR1

Gallus gallus

Domestic chicken

Ggal\FGFR3

Gallus gallus

Domestic chicken

Ggal\TADA2B

Gallus gallus

Domestic chicken

Ggal\FGFR2

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v8.0)

Drosophila melanogaster (Fruit fly) (1)

Gene Symbol

Score

Source

Alignment

6 of 10

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Model Summary Ribbon

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Allele

Disease

Interaction

References

Ada2b^NIG.9638R

ameliorates amyotrophic lateral sclerosis

modeled by Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

TADA2B; transcriptional adaptor 2B

15 of 15

608790

TADA2A; transcriptional adaptor 2A

5 of 15

602276

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

Ada2b

two hybrid, anti tag coimmunoprecipitation, anti tag western blot

(Torres-Zelada et al., 2019, Pankotai et al., 2013)

Ada2b - Ada1-2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011, Weake et al., 2009)

Ada2b - Ada2a

affinity chromatography technology, molecular sieving, multidimensional protein identification technology, anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, two hybrid, anti tag western blot

(Muratoglu et al., 2003)

Ada2b - Ada3

(Soffers et al., 2019, Torres-Zelada et al., 2019, Pankotai et al., 2013, Weake et al., 2011, Weake et al., 2009, Ciurciu et al., 2006, Kusch et al., 2003, Muratoglu et al., 2003)

Ada2b - Alh

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Atac3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Atxn7

anti tag coimmunoprecipitation, molecular sieving, western blot, peptide massfingerprinting

(Mohan et al., 2014, Weake et al., 2011, Weake et al., 2009)

Ada2b - Brf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Popova et al., 2018)

Ada2b - Bug22

(Weake et al., 2011)

Ada2b - CG11970

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - CG3815

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - CG3909

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - CG42724

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - CG45071

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - CG6470

anti tag coimmunoprecipitation, peptide massfingerprinting

(Shokri et al., 2019)

Ada2b - CG7839

(Weake et al., 2011)

Ada2b - CTCF

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - CrebB

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Deaf1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Dp

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - E2f2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - ERR

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Ets65A

anti tag coimmunoprecipitation, peptide massfingerprinting

(Shokri et al., 2019)

Ada2b - Ets97D

(Weake et al., 2011)

Ada2b - FoxK

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - GATAd

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - GATAe

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - HIP-R

experimental knowledge based

(Guruharsha et al., 2011)

Ada2b - Hcf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Hr3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Hr78

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Hsf

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Jra

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - M1BP

experimental knowledge based

(Guruharsha et al., 2011)

Ada2b - Max

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Mef2

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Myb

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Nipped-A

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot

(Popova et al., 2018, Weake et al., 2011, Weake et al., 2009, Kusch et al., 2003)

Ada2b - Pbp45

anti tag coimmunoprecipitation, peptide massfingerprinting

(Popova et al., 2018)

Ada2b - Ptx1

(Weake et al., 2011)

Ada2b - Saf6

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011, Weake et al., 2009)

Ada2b - Sf3b3

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016)

Ada2b - Sf3b5

anti tag coimmunoprecipitation, peptide massfingerprinting, two hybrid

(Stegeman et al., 2016)

Ada2b - Sgf11

anti tag coimmunoprecipitation, peptide massfingerprinting, anti tag western blot

(Weake et al., 2011, Weake et al., 2009, Weake et al., 2008)

Ada2b - Sgf29

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot, affinity chromatography technology, molecular sieving, multidimensional protein identification technology

(Soffers et al., 2019, Weake et al., 2011, Weake et al., 2009, Weake et al., 2008)

Ada2b - Spt20

anti tag coimmunoprecipitation, peptide massfingerprinting

(Stegeman et al., 2016, Weake et al., 2011, Weake et al., 2009)

Ada2b - Spt3

anti tag coimmunoprecipitation, peptide massfingerprinting, anti bait coimmunoprecipitation, western blot, two hybrid, multidimensional protein identification technology

(Torres-Zelada et al., 2019, Stegeman et al., 2016, Weake et al., 2011, Weake et al., 2009, Weake et al., 2008, Guelman et al., 2006, Kusch et al., 2003)

Ada2b - Spt7

anti tag coimmunoprecipitation, multidimensional protein identification technology, peptide massfingerprinting, two hybrid

(Torres-Zelada et al., 2019, Weake et al., 2011, Weake et al., 2009)

Ada2b - Stat92E

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - Taf10

anti tag coimmunoprecipitation, peptide massfingerprinting

(Kusch et al., 2003, Muratoglu et al., 2003)

Ada2b - Taf10b

(Weake et al., 2011, Weake et al., 2009)

Ada2b - Taf12

two hybrid, anti tag coimmunoprecipitation, peptide massfingerprinting

(Torres-Zelada et al., 2019, Weake et al., 2011, Weake et al., 2009)

Ada2b - Taf4

ion exchange chromatography, molecular sieving, western blot, anti bait coimmunoprecipitation

(Muratoglu et al., 2003)

Ada2b - Taf5

anti tag coimmunoprecipitation, peptide massfingerprinting, ion exchange chromatography, molecular sieving, western blot, anti bait coimmunoprecipitation

(Kusch et al., 2003)

Ada2b - Taf9

(Weake et al., 2011, Weake et al., 2009, Kusch et al., 2003, Muratoglu et al., 2003)

Ada2b - Tbp

anti tag coimmunoprecipitation, peptide massfingerprinting

(Muratoglu et al., 2003)

Ada2b - bab2

(Weake et al., 2011)

Ada2b - br

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - cg

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - chinmo

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - chn

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - ci

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - ct

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - d4

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - dve

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - e(y)2

anti bait coimmunoprecipitation, western blot, anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011, Kurshakova et al., 2009, Weake et al., 2009, Kurshakova et al., 2007)

Ada2b - fkh

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - fru

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - ftz-f1

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - gro

anti tag coimmunoprecipitation, peptide massfingerprinting

(Shokri et al., 2019)

Ada2b - kay

(Weake et al., 2011)

Ada2b - ken

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - l(3)mbt

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - not

anti tag coimmunoprecipitation, peptide massfingerprinting, western blot

(Cloud et al., 2019, Weake et al., 2011, Weake et al., 2009)

Ada2b - oc

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - p53

anti tag coimmunoprecipitation, anti tag western blot, pull down, western blot

(Pankotai et al., 2013, Kusch et al., 2003)

Ada2b - peb

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - pho

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - pnr

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - pps

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - rib

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - stc

anti tag coimmunoprecipitation, peptide massfingerprinting

(Weake et al., 2011)

Ada2b - sug