FB2026_03 , released September 17, 2026
CV Term Report
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Term SAGA complex ID (Ontology) GO:0000124 (Gene Ontology)
Definition A SAGA-type histone acetyltransferase complex that deubiquitinates H2A and/or H2B. This complex is organized into several functional submodules: a structural core including the activator binding module and consisting of ADA1 or a homolog, members of the SPT and TAF protein families as well as promotor recruitment factor TRRAP/TRA1, a histone acetyltransferase (HAT) module consisting of GCN5/KAT2A or PCAF/KAT2B, ADA2, ADA3/NGG1, and SGF29 or homologues thereof, a histone deubiquitinase (DUB) module consisting of ATXN7/SGF73, ATXN7L3/SGF11, ENY2/SUS1 and USP22/UBP8 or homologues thereof, and in some taxa a splicing module consisting of SF3B3 and SF3B5 or homologues thereof (not in fungi). In budding yeast also contains Spt8 which distinguishes it from SAGA-like (SLIK) complex (GO:0046695).[ PubMed:10637607 PubMed:17337012 PubMed:19056896 PubMed:20838651 PubMed:33004486 ]
Also Known As"Spt-Ada-Gcn5-acetyltransferase complex"
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     part_of | SAGA complex       --
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histone acetyltransferase complex
 |__SAGA-type complex__
catalytic complex      |
 |__peptidase complex__|
                       SAGA complex  27 rec.
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