FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
CV Term Report
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General Information
Term DNA damage response ID (Ontology) GO:0006974 (Gene Ontology)
Definition Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
Also Known As "cellular DNA damage response" ; "cellular response to DNA damage stimulus" ; "response to genotoxic stress"
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_BIOLOGICAL_PROCESS      49
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Genes
 DNA damage response (all annotations which use CV term, excluding "NOT" statements)      49
     involved_in | DNA damage response      49
Spanning Tree (Parents/Children)
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response to stress_____________
cellular response to stimulus__|
                               cellular response to stress
                                |__DNA damage response  293 rec.
                                    |__broken chromosome clustering
                                    |__DNA damage tolerance 17 rec.
                                    |   |__error-free postreplication DNA repair(+)
                                    |   |__translesion synthesis(+) 13 rec.
                                    |__DNA repair 213 rec.
                                    |   |__base-excision repair(+) 15 rec.
                                    |   |__chromosomal 5-methylcytosine DNA demethylation, oxidative deamination pathway
                                    |   |__DNA alkylation repair 2 rec.
                                    |   |__DNA replication proofreading 7 rec.
                                    |   |__DNA synthesis involved in DNA repair(+) 9 rec.
                                    |   |__double-strand break repair(+) 110 rec.
                                    |   |__guanine deglycation(+)
                                    |   |__interstrand cross-link repair(+) 16 rec.
                                    |   |__mismatch repair(+) 14 rec.
                                    |   |__mitochondrial DNA repair 1 rec.
                                    |   |__non-photoreactive DNA repair
                                    |   |__nucleotide-excision repair(+) 28 rec.
                                    |   |__protein-DNA covalent cross-linking repair 3 rec.
                                    |   |__pyrimidine dimer repair(+) 2 rec.
                                    |   |__recombinational repair(+) 66 rec.
                                    |   |__regulation of DNA repair(+) 17 rec.
                                    |   |__single strand break repair(+) 4 rec.
                                    |   |__UV-damage excision repair(+) 3 rec.
                                    |   |__viral DNA repair
                                    |__DNA repair-dependent chromatin remodeling 17 rec.
                                    |__intrinsic apoptotic signaling pathway in response to DNA damage 15 rec.
                                    |   |__intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(+) 7 rec.
                                    |   |__regulation of intrinsic apoptotic signaling pathway in response to DNA damage(+) 3 rec.
                                    |__signal transduction in response to DNA damage 41 rec.
                                    |   |__DNA damage checkpoint signaling(+) 37 rec.
                                    |   |__DNA damage response, signal transduction by p53 class mediator(+) 5 rec.
                                    |   |__DNA damage response, signal transduction resulting in transcription
                                    |__SOS response
                                    |__telomere maintenance in response to DNA damage 4 rec.
                                        |__protection from non-homologous end joining at telomere(+) 4 rec.
                                        |__regulation of telomere maintenance in response to DNA damage(+)
                                        |__telomere maintenance via base-excision repair
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Is a cellular response to stress
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Synonyms
  • "cellular DNA damage response" EXACT
    "cellular response to DNA damage stimulus" EXACT
    "response to DNA damage stimulus" BROAD
    "response to genotoxic stress" EXACT
Secondary IDs
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