FlyBase Allele Report: Dmel\mTor[HMS00904]

General Information

Symbol

Dmel\mTor^HMS00904

Species

D. melanogaster

Name

FlyBase ID

FBal0257579

Feature type

allele

Associated gene

Dmel\mTor

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00904}

Also Known As

TOR RNAi, HMS00904, UAS-TOR-RNAi, Tor-i, UAS-TOR^RNAi, UAS-mTOR-RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2010.12.1)

Mutagen

in vitro construct

(Ni et al., 2010.12.1)

Progenitor genotype

Carried in construct

P{TRiP.HMS00904}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2010.12.1)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00904

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis

modeled by Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cold stress response | larval stage, with Scer\GAL4^nSyb.PP

(Matsumura et al., 2025)

abnormal heat stress response | larval stage, with Scer\GAL4^nSyb.PP

(Matsumura et al., 2025)

abnormal osmotic stress response | larval stage, with Scer\GAL4^nSyb.PP

(Matsumura et al., 2025)

abnormal size | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

abnormal size | third instar larval stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

abnormal starvation stress response | larval stage, with Scer\GAL4^Cg.PU

(Xu et al., 2015)

abnormal stress response | larval stage, with Scer\GAL4^nSyb.PP

(Matsumura et al., 2025)

decreased body size | adult stage, with Scer\GAL4^Ilp2.PR

(Hasygar and Hietakangas, 2014)

decreased cell death | P-stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

decreased rate of adult locomotory behavior, with Scer\GAL4^elav.PU

(Planas-Serra et al., 2025)

female sterile, with Scer\GAL4^{VP16.nanos.UTR}, Scer\GAL4^VP16.otu, Scer\GAL4^nanos.PG

(Sopko et al., 2014)

increased cell death, with Scer\GAL4^Ugt36A1.PK

(Wolff et al., 2025)

increased cell death | oogenesis, with Scer\GAL4^nanos.PG

(Wang et al., 2019)

increased cell death | third instar larval stage, with Scer\GAL4^NP0001

(Xu et al., 2015)

visible | adult stage, with Scer\GAL4^eya.enh1+E+2

(Pletcher et al., 2019)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression under the control of Scer\GAL4^eya.enh1+E+2 results in glossy, small and misshapen eye phenotype.

(Pletcher et al., 2019)

The expression of Tor^HMS00904 under the control of Scer\GAL4^nos.PG leads to germline degeneration in the germarium.

(Wang et al., 2019)

Expression of Tor^HMS00904 under the control of Scer\GAL4^{Myo31DF-NP0001} results in premature autophagy in the larval midgut and shortened gastric caeca at an early age, 4 hrs and 0 hrs before puparium formation, and decreased autophagy 2 hrs after puparium formation, but the gastric caeca size is not significantly different from controls at 4 hrs after puparium formation.

Expression of Tor^HMS00904 under the control of Scer\GAL4^cg.PU results in a lack of autophagic difference in the larval fat body between fed and starved flies as compared to controls.

(Xu et al., 2015)

Expression of Tor^HMS00904 under the control of Scer\GAL4^elav-C155 has no effect on bouton size.

(Deivasigamani et al., 2014)

Scer\GAL4^Ilp2.PR-mediated expression results in a significant reduction in the body weight of emerging adults compared to controls.

(Hasygar and Hietakangas, 2014)

Females heterozygous for Tor^HMS00904 and MTD-Gal4 (consists of Scer\GAL4^{otu.T:Hsim\VP16}, Scer\GAL4^nos.PG and Scer\GAL4^{nos.UTR.T:Hsim\VP16}) crossed to Tor^HMS00904 males results in: no eggs; egg/embryonic phenotype: no vitellogenic egg chambers; oogenesis defect.

(Sopko et al., 2014)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^nSyb.PP, mTor^HMS00904 has abnormal heat stress response | larval stage phenotype, suppressible by Phae1^UAS.cMa, Scer\GAL4^nSyb.PP

(Matsumura et al., 2025)

Scer\GAL4^NP0001, mTor^HMS00904 has decreased cell death | P-stage phenotype, suppressible by Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

Scer\GAL4^NP0001, mTor^HMS00904 has abnormal size | third instar larval stage phenotype, suppressible by Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

Enhancer of

Statement

Reference

mTor^HMS00904, Scer\GAL4^elav.PU is an enhancer of decreased rate of adult locomotory behavior phenotype of Rps6kc1^HMJ22016, Scer\GAL4^elav.PU

(Planas-Serra et al., 2025)

Suppressor of

Statement

Reference

mTor^HMS00904, Scer\GAL4^NP0001 is a suppressor of decreased cell death | P-stage phenotype of Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

mTor^HMS00904, Scer\GAL4^NP0001 is a suppressor of abnormal size | P-stage phenotype of Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

Scer\GAL4^elav-C155/mTor^HMS00904 is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^elav-C155, Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

Other

Statement

Reference

Rps6kc1^HMJ22016, Scer\GAL4^elav.PU, mTor^HMS00904 has short lived phenotype

(Planas-Serra et al., 2025)

Phenotype Manifest In

Suppressed by

Statement

Reference

Scer\GAL4^NP0001, mTor^HMS00904 has embryonic/larval midgut | third instar larval stage phenotype, suppressible by Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

Scer\GAL4^NP0001, mTor^HMS00904 has gastric caecum | third instar larval stage phenotype, suppressible by Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

Suppressor of

Statement

Reference

mTor^HMS00904, Scer\GAL4^NP0001 is a suppressor of embryonic/larval midgut | P-stage phenotype of Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

mTor^HMS00904, Scer\GAL4^NP0001 is a suppressor of gastric caecum | P-stage phenotype of Atg1^JF02273, Scer\GAL4^NP0001

(Xu et al., 2015)

Scer\GAL4^elav-C155/mTor^HMS00904 is a suppressor of terminal bouton phenotype of Scer\GAL4^elav-C155, Vap33^P58S.cRa.UAS

(Deivasigamani et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of Atg1^JF02273 and Tor^HMS00904 under the control of Scer\GAL4^{Myo31DF-NP0001} restores autophagy and gastric caeca contraction to levels similar to those seen in controls.

(Xu et al., 2015)

Expression of Tor^HMS00904 suppresses the enlarged bouton phenotype seen when Vap-33A^{P58S.cRa.Scer\UAS} is expressed under the control of Scer\GAL4^elav-C155.

(Deivasigamani et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

33951