FB2026_02 , released June 18, 2026
Allele: Dmel\crqGD784
Open Close
General Information
Symbol
Dmel\crqGD784
Species
D. melanogaster
Name
FlyBase ID
FBal0209301
Feature type
allele
Associated gene
Dmel\crq
Associated Insertion(s)
Carried in Construct
P{GD784}
Key Links
Genomic Maps

Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Dickson et al., 2007.7.18)
Mutagen
in vitro construct
(Dickson et al., 2007.7.18)
Progenitor genotype
Carried in construct
P{GD784}
Cytology
Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
dsRNA-GD784
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  amyotrophic lateral sclerosis type 8
      modeled by Vap33P58S.UAS.Tag:FLAG
      (Sanhueza et al., 2015)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of crqGD784 under the control of Scer\GAL4Hml.Δ results in significantly reduced survival and increased parasite load when infected with Leishmania amastigotes, along with a significant decrease in intracellular parasites in the hemocytes, and an increase in the number of promastigotes 8 days post-infection, as compared to wild type.

      (Okuda et al., 2016)

      Expression of crqGD784 RNAi under the control Scer\GAL4Hml.Δ driver significantly improves the lowered survival of adult flies on lard-supplemented diet compared to controls.

      (Woodcock et al., 2015)

      Expression of crqGD784 (co-expressed with Dcr-2Scer\UAS.cDa) in posterior epidermal cells under the control of Scer\GAL4en-e16E prevents phagocytic clearance of ddaC neuron dendrite debris following pupal stage dendritic pruning. Similarly, when larval dendrites are injured (severed with an infrared laser) expression of crqGD784 blocks dendritic debris clearance.

      (Han et al., 2014)

      Adults expressing crqGD784 under the control of Scer\GAL4elav.PLu (in the presence of Dcr-2Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

      (Neely et al., 2010)
      External Data
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      crqGD784/Scer\GAL4C587 is an enhancer of increased cell number | spermatogenesis phenotype of drprΔ5

      (Zohar-Fux et al., 2022)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      crqGD784/Scer\GAL4C587 is an enhancer of spermatogonium | increased number phenotype of drprΔ5

      (Zohar-Fux et al., 2022)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 1 )
      Linkouts
      Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      crqGD784
      Name Synonyms
      Secondary FlyBase IDs
        References (13)