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General Information
Symbol
Dmel\SF2UAS.GFP
Species
D. melanogaster
Name
FlyBase ID
FBal0323542
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of a SF2 cDNA tagged at the N-terminal end with GFP.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing SF2UAS.GFP under the control of Scer\GAL4GMR.PU results in a strong rough eye phenotype.

Expression of SF2Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PF results in a decreased eclosion rate, and surviving adults exhibit reduced eye size and significant necrosis in the eye, as compared to controls. Third instar larvae expressing SF2Scer\UAS.T:Avic\GFP under the control of Scer\GAL4GMR.PF exhibit disorganization and increased apoptosis in the eye disc posterior to the morphogenetic furrow, with disorganization of photoreceptor cells, and a reduction in the number of detectable cone cells; optic lobes in these larvae do not exhibit increased apoptosis as compared to controls, and do not show any obvious defects in photoreceptor neuron axon localization or lamina monopolar neuron arborization in the medulla.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Phenotype Manifest In
Enhanced by
Statement
Reference
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Co-expressing SF2UAS.GFP together with a weakly expressing Hsap\TARDBPUAS.cPa line under the control of Scer\GAL4GMR.PU results in an enhanced rough eye phenotype.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
SF2Scer\UAS.T:Avic\GFP
SF2UAS.GFP
Name Synonyms
Secondary FlyBase IDs
    References (4)