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General Information
Symbol
Hsap\TARDBPUAS.TDPBR
Species
H. sapiens
Name
FlyBase ID
FBal0344470
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-TDP-43_TDPBR
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of the wild-type Hsap\TARDBP coding sequence. The TDPBR (TDP-43 binding region) regulatory sequence from the Hsap\TARDBP 3' UTR has been inserted downstream of the coding sequence.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU does not cause a discernible eye phenotypes.

The expression of Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU results in no eye phenotype.

The expression of Hsap\TARDBPUAS.TDPBR / Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU / Scer\GAL4GMR.PU results in no eye phenotype.

Flies expressing Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU have structurally normal eyes.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Phenotype Manifest In
Enhancer of
Additional Comments
Genetic Interactions
Statement
Reference
Xenogenetic Interactions
Statement
Reference

Coexpression of CG42724UY5237 and Hsap\TARDBPUAS.TDPBR under the control of Scer\GAL4GMR.PU results in no eye phenotype with only one copy for each transgene and driver.

Coexpression of Hsap\TARDBPUAS.TDPBR / Hsap\TARDBPUAS.TDPBR enhances the rough eye phenotype induced by expression of CG42724UY5237 under the control of Scer\GAL4GMR.PU / Scer\GAL4GMR.PU.

Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (1)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (1)
Reported As
Symbol Synonym
Hsap\TARDBPUAS.TDPBR
Name Synonyms
Secondary FlyBase IDs
    References (3)