FlyBase Allele Report: Hsap\TARDBP[UAS.cLa]

General Information

Symbol

Hsap\TARDBP^UAS.cLa

Species

H. sapiens

Name

Saccharomyces cerevisiae UAS construct a of Lu

FlyBase ID

FBal0302647

Feature type

allele

Associated gene

Hsap\TARDBP

Associated Insertion(s)

Carried in Construct

P{UAS-hTDP-43.L}

Also Known As

UAS-hTDP-43, UAS-hTDP-43^WT, UAS-TDP-43

Key Links

Transgenic product class

wild_type

(Lu et al., 2009)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Lu et al., 2009)

Mutagen

in vitro construct

(Lu et al., 2009)

Progenitor genotype

Carried in construct

P{UAS-hTDP-43.L}

Cytology

Description

UASt regulatory sequences drive expression of full-length Hsap\TARDBP.

(Lu et al., 2009)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

Hsap\TARDBP

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of amyotrophic lateral sclerosis type 10

CEC

(Yusuff et al., 2023)

CEA

(Sanna et al., 2020)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates fragile X-associated tremor/ataxia syndrome

modeled by Zzzz\CGG^90.UAS.EGFP

(Galloway et al., 2014)

model of amyotrophic lateral sclerosis type 10

is ameliorated by HDAC1^GD4513

(Sanna et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | temperature conditional, with Scer\GAL4^elav.PU

(Choksi et al., 2014)

abnormal neuroanatomy | third instar larval stage, with Scer\GAL4²²¹

(Lu et al., 2009)

lethal - all die before end of larval stage, with Scer\GAL4^da.PU

(Choksi et al., 2014)

lethal - all die before end of larval stage, with Scer\GAL4^Mef2.PR

(Choksi et al., 2014)

lethal - all die before end of P-stage, with Scer\GAL4^VGlut1.PD

(Choksi et al., 2014)

lethal - all die during embryonic stage, with Scer\GAL4^how-24B

(Choksi et al., 2014)

lethal - all die during embryonic stage, with Scer\GAL4^sev.PU

(Choksi et al., 2014)

lethal - all die during embryonic stage | heat sensitive, with Scer\GAL4^elav.PU

(Choksi et al., 2014)

melanotic necrosis | adult stage, with Scer\GAL4^Bx-MS1096

(Yusuff et al., 2023)

melanotic necrosis | adult stage, with Scer\GAL4^CCAP.PP

(Yusuff et al., 2023)

short lived, with Scer\GAL4^Appl.PU

(Deshpande et al., 2016)

viable, with Scer\GAL4^Bx-MS1096

(Yusuff et al., 2023)

viable, with Scer\GAL4^ey-OK107

(Choksi et al., 2014)

viable, with Scer\GAL4^GMR.PU

(Choksi et al., 2014)

viable, with Scer\GAL4^ple.PF

(Choksi et al., 2014)

visible | adult stage, with Scer\GAL4^Bx-MS1096

(Yusuff et al., 2023)

visible | adult stage, with Scer\GAL4^CCAP.PP

(Yusuff et al., 2023)

visible | adult stage, with Scer\GAL4^vg.PU

(Li et al., 2013)

Phenotype Manifest In

Detailed Description

Statement

Reference

Expression of Hsap\TARDBP^Scer\UAS.cLa driven by Scer\GAL4^Appl.PU results in a decreased adult life span compared to controls.

(Deshpande et al., 2016)

Expression of Hsap\TARDBP^Scer\UAS.cLa under the control of Scer\GAL4^elav.PU results in embryonic lethality at 25[o]C, but these flies are viable at 18[o]C and exhibit abnormal climbing ability, as compared to controls.

Expression of Hsap\TARDBP^Scer\UAS.cLa under the control of Scer\GAL4^GMR.PU does not lead to any obvious eye phenotype.

(Choksi et al., 2014)

Expression of Hsap\TARDBP^Scer\UAS.cLa under the control of Scer\GAL4^vg.PU results in a subset of flies possessing supernumerary scutellar bristles.

(Li et al., 2013)

Expression of Hsap\TARDBP^Scer\UAS.cLa under the control of Scer\GAL4²²¹ results in a significant increase in dendritic branching in the ddaE and ddaF neurons of third instar larvae compared to controls. The increase in dendritic branching is mostly seen near the cell body.

(Lu et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\TARDBP^UAS.cLa, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^GMR.PU, Zzzz\CGG^90.UAS.EGFP

(Galloway et al., 2014)

Hsap\TARDBP^UAS.cLa, Scer\GAL4^elav.PU is a suppressor of abnormal locomotor behavior phenotype of Scer\GAL4^elav.PU, Zzzz\CGG^90.UAS.EGFP

(Galloway et al., 2014)

Phenotype Manifest In

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of dco^Scer\UAS.cUa does not lead to any obvious eye phenotype in flies expressing Hsap\TARDBP^Scer\UAS.cLa under the control of Scer\GAL4^GMR.PU.

(Choksi et al., 2014)

Co-expression of Hsap\TARDBP^UAS.cLa suppresses the neurodegeneration seen in flies expressing Zzzz\CGG^90.UAS.EGFP under the control of Scer\GAL4^GMR.PU. The locomotion defects seen in flies expressing Zzzz\CGG^90.UAS.EGFP neuronally is also suppressed in these flies.

(Galloway et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Hsap\TARDBP^Scer\UAS.cLa

Hsap\TARDBP^Scer\UAS.cUa

Hsap\TARDBP^UAS.cLa

Name Synonyms

Saccharomyces cerevisiae UAS construct a of Lu

Secondary FlyBase IDs

References (8)

Report Sections

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