FlyBase Allele Report: Hsap\SIGMAR1[UAS.cCa]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Hsap\SIGMAR1^UAS.cCa

General Information

Symbol

Hsap\SIGMAR1^UAS.cCa

Species

H. sapiens

Name

UAS construct a of Couly

FlyBase ID

FBal0359876

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{UAS-hSIGMAR1.C}

Key Links

Transgenic product class

(Couly et al., 2020)

(Couly et al., 2020)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Couly et al., 2020)

(Couly et al., 2020)

Mutagen

in vitro construct

(Couly et al., 2020)

Progenitor genotype

Carried in construct

P{UAS-hSIGMAR1.C}

Cytology

Description

UASt regulatory sequences drive expression of a wild-type Hsap\SIGMAR1 cDNA.

(Couly et al., 2020)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates amyotrophic lateral sclerosis type 10

modeled by Hsap\TARDBP^{M.UAS.Tag:FLAG}

(Couly et al., 2020)

ameliorates C9orf72 frontotemporal dementia and/or amyotrophic lateral sclerosis

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Lee et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

Hsap\SIGMAR1^UAS.cCa, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Lee et al., 2020)

Hsap\SIGMAR1^UAS.cCa, Scer\GAL4^elav-C155 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav-C155, Zzzz\GGGGCC^30.UAS.EGFP

(Lee et al., 2020)

Hsap\SIGMAR1^UAS.cCa, Scer\GAL4^elav-C155 is a suppressor | partially of abnormal neurophysiology | adult stage phenotype of Scer\GAL4^elav-C155, Zzzz\GGGGCC^30.UAS.EGFP

(Lee et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

Hsap\SIGMAR1^UAS.cCa, Scer\GAL4^GMR.PU is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Lee et al., 2020)

Hsap\SIGMAR1^UAS.cCa, Scer\GAL4^elav-C155 is a suppressor | partially of flight muscle cell phenotype of Scer\GAL4^elav-C155, Zzzz\GGGGCC^30.UAS.EGFP

(Lee et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Hsap\SIGMAR1^UAS.cCa

Name Synonyms

UAS construct a of Couly

Secondary FlyBase IDs

References (2)

Report Sections