Open Close
General Information
Symbol
Dmel\Hsc70-3UAS.cEa
Species
D. melanogaster
Name
Saccharomyces cerevisiae UAS construct a of Elefant
FlyBase ID
FBal0098845
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Also Known As
UAS-Hsc70-3.WT, UAS-HSC3
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UASt regulatory sequences drive expression of a 2.1kb EcoRI fragment containing the Hsc70-3 coding region.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 1 )
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expressing Hsc70-3UAS.cEa under the control of Scer\GAL4elav-C155 does not induce bang sensitivity and has no effect in adult climbing ability or DA neuron number.

Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4Act is able to extend the mean life span under hyperoxic conditions.

Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4337Y has no adverse effects. Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4how-24B does not result in a mutant phenotype.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
NOT Enhancer of
Suppressor of
NOT Suppressor of
Phenotype Manifest In
NOT Enhancer of
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Co-expression of Hsc70-3Scer\UAS.cEa suppresses the ommatidial degeneration and loss of pigmentation induced by Scer\GAL4GMR.PF>Hsap\GJB3F137L.Scer\UAS.T:Hsap\MYC in more than 90% of flies.

Expression of Hsc70-3Scer\UAS.cEa under the control of Scer\GAL4arm.PS in pcx3 embryos which lack maternal and zygotic pcx function partially rescues the neurogenic phenotype: 67% of embryos are partially rescued and 33% are not rescued.

Xenogenetic Interactions
Statement
Reference

Co-expression of Hsc70-3Scer\UAS.cEa fails to suppress the eye phenotypes of adult flies expressing Hsap\ATXN3tr.Q78.Scer\UAS.T:Ivir\HA1 under the control of Scer\GAL4GMR.PU.

Co-expression of Hsc70-3Scer\UAS.cEa fails to suppress the eye phenotypes of flies expressing Hsap\APP2xAPP.SP.Scer\UAS under the control of Scer\GAL4GMR.PU.

Expression of Hsc70-3Scer\UAS.cEa does not suppress the external eye degeneration seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 is expressed under the control of Scer\GAL4GMR.PU.

Expression of Hsc70-3Scer\UAS.cEa does not suppress the external eye degeneration phenotype seen when Zzzz\CAG127Q.Scer\UAS.T:Ivir\HA1 and DnaJ-1Scer\UAS.cKb are co-expressed under the control of Scer\GAL4GMR.PU.

Complementation and Rescue Data
Comments

Animals expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4how-24B generally die as pupae or larvae (depending on the P{UAS-Hsc70-3.D231S} line used). This lethality is partially rescued by coexpression of Hsc70-3Scer\UAS.cEa.

Images (0)
Mutant
Wild-type
Stocks (2)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (3)
Reported As
Symbol Synonym
Hsc70-3Scer\UAS.cEa
Hsc70-3UAS.cEa
Name Synonyms
Saccharomyces cerevisiae UAS construct a of Elefant
Secondary FlyBase IDs
    References (12)