FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\Hsc70-3D231S.UAS
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General Information
Symbol
Dmel\Hsc70-3D231S.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0060648
Feature type
allele
Associated gene
Dmel\Hsc70-3
Associated Insertion(s)
Carried in Construct
P{UAS-Hsc70-3.D231S}
Also Known As
Hsc3D231S, UAS-Hsc70-3DN, UAS-BipDN
Key Links
Transgenic product class
missense_variant
(Elefant and Palter, 1999)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Elefant and Palter, 1999)
Mutagen
in vitro construct
(Elefant and Palter, 1999, Elefant and Palter, 1997)
Progenitor genotype
Hsc70-3UAS.cEa
(Elefant and Palter, 1999)
Carried in construct
P{UAS-Hsc70-3.D231S}
Cytology
Description

Amino acid replacement: D231S.

(Elefant and Palter, 1999)

Encodes a Hsc70-3 protein with a single point mutation in the ATP binding site.

(Elefant and Palter, 1997)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Hsc70-3
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Projection neurons expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4GH146 show mild defects in targeting.

      (Sekine et al., 2013)

      Animals expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4337Y die as first or second instar larvae. Animals expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4how-24B generally die as pupae or larvae (depending on the P{UAS-Hsc70-3.D231S} line used). Animals expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4how-24B that die as embryos are unable to puncture the egg membrane and hatch and those larvae that do hatch are unable to crawl. Embryos expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4how-24B have a wild-type muscle pattern. The majority of newly hatched larvae expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4156Y are able to sense, locate and burrow into a yeast paste food source within 20 minutes in a behavioural assay. 2 day old larvae expressing Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4156Y are unable to locate the food source.

      (Elefant and Palter, 1999)

      Dominant lethal allele.

      (Elefant and Palter, 1997)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of Hsc70-3D231S.Scer\UAS under the control of Scer\GAL4GH146 enhances the targeting defects seen in homozygous meigo1 projection neuron clones.

      (Sekine et al., 2013)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially rescued by

      Hsc70-3D231S.UAS is partially rescued by Scer\GAL4how-24B/Hsc70-3UAS.cEa

      (Elefant and Palter, 1999)
      Comments

      The lethality seen in Hsc70-3D231S.Scer\UAS, Scer\GAL4how-24B flies is partially rescued by coexpression of Hsc70-3Scer\UAS.cEa.

      (Elefant and Palter, 1999)
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      D231S
      (Elefant and Palter, 1995)
      HSC3D231S
      (Chen et al., 2015, Elefant and Palter, 1997)
      Hsc3D231S
      (Sekine et al., 2013)
      Hsc70-3D231S.Scer\UAS
      Hsc70-3D231S.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (13)