FlyBase Allele Report: Dmel\meigo[1]

General Information

Symbol

Dmel\meigo¹

Species

D. melanogaster

Name

FlyBase ID

FBal0285247

Feature type

allele

Associated gene

Dmel\meigo

Associated Insertion(s)

Carried in Construct

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Nature of the Allele

Allele class

Mutagen

Progenitor genotype

Cytology

Description

Amino acid replacement: C89Y.

(Sekine et al., 2013)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:21,139,178..21,139,178 [+]

Nucleotide change:

G21139178A

Amino acid change:

C89Y | meigo-PA; C89Y | meigo-PB

Reported amino acid change:

C89Y

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Sekine et al., 2013)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone

(Sekine et al., 2013)

Phenotype Manifest In

adult antennal lobe projection neuron | somatic clone

(Sekine et al., 2013)

adult antennal lobe projection neuron DL1 adPN | somatic clone

(Sekine et al., 2013)

Detailed Description

Statement

Reference

Homozygous anterodorsal projection neurons (marked with Scer\GAL4^GH146 and clones induced in neuroblasts) show an aberrant medial shift of dendrite targeting in the antennal lobe. The dendrites retain their normal position along the dorsoventral axis. Homozygous projection clones marked with Scer\GAL4^Mz19, which normally target laterally located glomeruli VA1d and DC3 also show a medial shift of dendrites. Homozygous projection neuron clones marked with Scer\GAL4^NP5103, which normally target medial glomerulus VM2 still target properly, with a glomerular spillover in 46% of cases.

The majority of homozygous single cell DL1 projection neuron clones have marked defects in dendrite targeting along the mediolateral axis. They often fail to refine into the DL1 glomerulus and innervate multiple glomeruli located medially to DL1.

Homozygous olfactory receptor neuron clones show a significant medial shift in their glomerular targeting compared to wild-type controls.

(Sekine et al., 2013)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

meigo¹ has abnormal neuroanatomy | adult stage | somatic clone phenotype, enhanceable by Hsc70-3^K97S.UAS/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | adult stage | somatic clone phenotype, enhanceable by Hsc70-3^D231S.UAS/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | adult stage | somatic clone phenotype, enhanceable by ninaE^G69D.UAS/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | adult stage | somatic clone phenotype, enhanceable by Scer\GAL4^GH146/Eph^UAS.Tag:MYC

(Sekine et al., 2013)

Suppressed by

Statement

Reference

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by Scer\GAL4^GH146/Ephrin^UAS.Tag:MYC

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, suppressible | partially by Ephrin^UAS.cBa/Scer\GAL4^GH146

(Sekine et al., 2013)

NOT suppressed by

Statement

Reference

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Scer\GAL4^GH146/CadN^UAS.cIa

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Dscam1^UAS.cUa/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Sema1a^UAS.cYa/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Ephrin^{NQ.UAS.Tag:MYC}/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by frc^UAS.Tag:MYC/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by sll^UAS.cLa/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has abnormal neuroanatomy | somatic clone | adult stage phenotype, non-suppressible by Efr^UAS.N.Tag:HA/Scer\GAL4^GH146

(Sekine et al., 2013)

Phenotype Manifest In

Enhanced by

Statement

Reference

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, enhanceable by Hsc70-3^K97S.UAS/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, enhanceable by Hsc70-3^D231S.UAS/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, enhanceable by ninaE^G69D.UAS/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, enhanceable by Scer\GAL4^GH146/Eph^UAS.Tag:MYC

(Sekine et al., 2013)

Suppressed by

Statement

Reference

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, suppressible | partially by Scer\GAL4^GH146/Ephrin^UAS.Tag:MYC

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, suppressible | partially by Ephrin^UAS.cBa/Scer\GAL4^GH146

(Sekine et al., 2013)

NOT suppressed by

Statement

Reference

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, non-suppressible by frc^UAS.Tag:MYC/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, non-suppressible by sll^UAS.cLa/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, non-suppressible by Efr^UAS.N.Tag:HA/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, non-suppressible by Scer\GAL4^GH146/CadN^UAS.cIa

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, non-suppressible by Dscam1^UAS.cUa/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, non-suppressible by Sema1a^UAS.cYa/Scer\GAL4^GH146

(Sekine et al., 2013)

meigo¹ has adult antennal lobe projection neuron | somatic clone phenotype, non-suppressible by Ephrin^{NQ.UAS.Tag:MYC}/Scer\GAL4^GH146

(Sekine et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

Expression of either frc^{Scer\UAS.T:Hsap\MYC}, sll^Scer\UAS.cLa or Efr^{Scer\UAS.N.T:Ivir\HA1} under the control of Scer\GAL4^GH146 does not suppress the dendrite mistargeting of meigo¹ single cell anterodorsal projection neuron clones.

Expression of either ninaE^{G69D.Scer\UAS}, Hsc70-3^{D231S.Scer\UAS} or Hsc70-3^{K97S.Scer\UAS} under the control of Scer\GAL4^GH146 enhances the targeting defects seen in homozygous meigo¹ projection neuron clones.

Expression of either Ephrin^{Scer\UAS.T:Hsap\MYC} or Ephrin^Scer\UAS.cBa under the control of Scer\GAL4^GH146 partially suppresses the targeting defects seen in homozygous meigo¹ DL1 projection neuron clones.

Expression of either CadN^Scer\UAS.cIa, Dscam^Scer\UAS.cUa or Sema-1a^Scer\UAS.cYa under the control of Scer\GAL4^GH146 does not suppress the dendrite targeting defects seen in homozygous meigo¹ projection neuron clones.

Expression of Eph^{Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GH146 enhances the targeting defects seen in homozygous meigo¹ DL1 projection neuron clones.

Expression of Ephrin^{NQ.Scer\UAS.T:Hsap\MYC} under the control of Scer\GAL4^GH146 does not suppress the dendrite refinement defects seen in homozygous meigo¹ single-cell projection neuron clones.

(Sekine et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

meigo¹

(Kamemura et al., 2022, Sekine et al., 2013)

meigo^B3-37

(Kamemura et al., 2022)

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

Open Close