Open Close
General Information
Symbol
Dmel\EphrinUAS.Tag:MYC
Species
D. melanogaster
Name
FlyBase ID
FBal0196834
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Nature of the Allele
Allele class
Mutations Mapped to the Genome
 
Type
Location
Additional Notes
References
Associated Sequence Data
DNA sequence
Protein sequence
 
 
Progenitor genotype
Carried in construct
Cytology
Nature of the lesion
Statement
Reference

UAS regulatory sequences drive expression of Ephrin, which is tagged in-frame to 6 copies of the Tag:MYC epitope. The Ephrin sequence corresponds to the full-length cDNA clone RE46807.

Allele components
Product class / Tool use(s)
Encoded product / tool
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Expression of EphrinScer\UAS.T:Hsap\MYC in the midline glia of embryos, driven by Scer\GAL4sim.PS, leads to the failure of many commissural axons to cross the midline and form normal commissures. The CNS in these embryos often appears less compact.

In the mushroom bodies of adult flies that express EphrinScer\UAS.T:Hsap\MYC, under the control of Scer\GAL4OK107, the dorsal lobes are absent and the medial β projections are thicker. In 50% of cases the β lobes appear to be fused at the midline.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Suppressor of
NOT Suppressor of
Phenotype Manifest In
Suppressed by
Statement
Reference
NOT suppressed by
Suppressor of
NOT Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

Expression of EphrinScer\UAS.T:Hsap\MYC under the control of Scer\GAL4GH146 partially suppresses the targeting defects seen in homozygous meigo1 DL1 projection neuron clones.

Expression of EphrinScer\UAS.T:Hsap\MYC in the midline glia of embryos, driven by Scer\GAL4sim.PS, in an Ephx652 background does not cause the disruption of commissural axons seen when the transgene is expressed in wild-type embryos.

Flies that express EphrinScer\UAS.T:Hsap\MYC under the control of either Scer\GAL4OK107 or Scer\GAL4elav.PLu, in an Ephx652 background, show the same α'/α lobe defects as flies expressing the transgene in a wild-type background and as Ephx652 flies with no transgene.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments
Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
EphrinScer\UAS.T:Hsap\MYC
EphrinUAS.Tag:MYC
Name Synonyms
Secondary FlyBase IDs
    References (3)