FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Hsap\TARDBPUAS.cPa
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General Information
Symbol
Hsap\TARDBPUAS.cPa
Species
H. sapiens
Name
FlyBase ID
FBal0344469
Feature type
allele
Associated gene
Hsap\TARDBP
Associated Insertion(s)
Carried in Construct
M{UAS-hTARDBP.P}
Key Links
Transgenic product class
wild_type
(Pons et al., 2017)
Mutagen
Nature of the Allele
Transgenic product class
wild_type
(Pons et al., 2017)
Mutagen
in vitro construct
(Pons et al., 2017)
Progenitor genotype
Carried in construct
M{UAS-hTARDBP.P}
Cytology
Description

UASt regulatory sequences drive expression of the wild-type, untagged Hsap\TARDBP coding sequence.

(Pons et al., 2017)
Allele components
Component
Use(s)
Regulatory region(s)
UASt
Encoded product / tool
Hsap\TARDBP
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 1 )
      Disease
      Evidence
      References
      model of  amyotrophic lateral sclerosis type 10
      CEA
      (Pons et al., 2017)
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expressing Hsap\TARDBPUAS.cPa under the control of Scer\GAL4GMR.PU does not cause a discernible eye phenotypes.

      (Miguel et al., 2018)

      Depending on the insertion line used, expressing Hsap\TARDBPUAS.cPa under the control of Scer\GAL4GMR.PU can result in a rough eye phenotype in the posterior portion of the eye.

      (Pons et al., 2017)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressed by
      Statement
      Reference

      Hsap\TARDBPUAS.cPa, Scer\GAL4GMR.PU has visible phenotype, suppressible | partially by SF2GD12097, Scer\GAL4GMR.PU

      (Pons et al., 2017)
      Enhancer of
      Phenotype Manifest In
      Suppressed by
      Statement
      Reference

      Hsap\TARDBPUAS.cPa, Scer\GAL4GMR.PU has eye phenotype, suppressible | partially by SF2GD12097, Scer\GAL4GMR.PU

      (Pons et al., 2017)
      Enhancer of
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      SF2GD12097 reduces the extent of the rough eye phenotype when co-expressed with a strongly expressing Hsap\TARDBPUAS.cPa line under the control of Scer\GAL4GMR.PU.

      Co-expressing SF2UAS.GFP together with a weakly expressing Hsap\TARDBPUAS.cPa line under the control of Scer\GAL4GMR.PU results in an enhanced rough eye phenotype.

      Co-expressing Sf3b1GD8837 together with a weakly expressing Hsap\TARDBPUAS.cPa line under the control of Scer\GAL4GMR.PU enhances defects in ommatidia structures in the posterior of the eye.

      Flies which co-express Rbp1UAS.GFP together with a weakly expressing Hsap\TARDBPUAS.cPa line under the control of Scer\GAL4GMR.PU have structurally normal eyes.

      (Pons et al., 2017)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      Hsap\TARDBPUAS.cPa
      Name Synonyms
      Secondary FlyBase IDs
        References (2)