FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\eIF1A645
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General Information
Symbol
Dmel\eIF1A645
Species
D. melanogaster
Name
FlyBase ID
FBal0180068
Feature type
allele
Associated gene
Dmel\eIF1A
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Collins and Cohen, 2005)
Progenitor genotype
Cytology
Description

Amino acid replacement: W70term.

(Li et al., 2014)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3R:18,281,698..18,281,698 [+]
Nucleotide change:

G18281698A

Amino acid change:

W70term | eIF1A-PA; W70term | eIF1A-PB; W70term | eIF1A-PC

Reported amino acid change:

W70term

Comment:

G to A nucleotide change at the second or third position of the Trp codon leads to a nonsense mutation (exact site of mutation unspecified). Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Li et al., 2014)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  fragile X-associated tremor/ataxia syndrome
      modeled by Zzzz\CGG90.UAS.EGFP
      (Linsalata et al., 2019)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      eIF1A645 is an enhancer of visible phenotype of Scer\GAL4C-765, smo5A.UAS.Tag:FLAG

      (Collins, 2005.7.7, Collins and Cohen, 2005)
      Suppressor of
      Statement
      Reference

      eIF-1A[+]/eIF1A645 is a suppressor of visible phenotype of spn-BBU

      (Li et al., 2014)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      eIF1A645 is an enhancer of wing phenotype of Scer\GAL4C-765, smo5A.UAS.Tag:FLAG

      (Collins and Cohen, 2005)
      Suppressor of
      Statement
      Reference

      eIF-1A[+]/eIF1A645 is a suppressor of egg chorion phenotype of spn-BBU

      (Li et al., 2014)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer

      Selected as: a modifier of the mild hh loss-of-function phenotype seen in the wings of flies expressing smo5A.Scer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4C-765.

      (Collins and Cohen, 2005)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (5)
      Reported As
      Symbol Synonym
      EIF1A645
      (Linsalata et al., 2019)
      I645
      (Collins and Cohen, 2005)
      I654
      (Collins and Cohen, 2005)
      eIF-1A645
      eIF1A645
      (Li et al., 2014, Collins, 2005.7.7)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)