FB2026_01 , released March 12, 2026
FB2026_01 , released March 12, 2026
Allele: Dmel\HDAC6RNAi.UAS
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General Information
Symbol
Dmel\HDAC6RNAi.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0215188
Feature type
allele
Associated gene
Dmel\HDAC6
Associated Insertion(s)
Carried in Construct
P{UAS-HDAC6.RNAi}
Key Links
Transgenic product class
RNAi_reagent
(Pandey et al., 2007)
Mutagen
Nature of the Allele
Transgenic product class
RNAi_reagent
(Pandey et al., 2007)
Mutagen
in vitro construct
(Pandey et al., 2007)
Progenitor genotype
Carried in construct
P{UAS-HDAC6.RNAi}
Cytology
Description

Template containing HDAC6 sequences.

(Pandey et al., 2007)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
HDAC6
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  neurodegenerative disease
      modeled by Zzzz\CGG90.UAS.EGFP
      (Todd et al., 2010)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Expression of HDAC6dsRNA.Scer\UAS under the control of HDAC6dsRNA.Scer\UAS results in progressive degeneration of the adult eye architecture with disorganized ommatidial array and ubiquitin-positive pathological inclusions.

      (Lee et al., 2010)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      HDAC6RNAi.UAS, Scer\GAL4GMR.PF is an enhancer of visible | heat sensitive phenotype of Scer\GAL4GMR.PF, Zzzz\CGG90.UAS.EGFP

      (Todd et al., 2010)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      HDAC6RNAi.UAS, Scer\GAL4GMR.PF is an enhancer of eye | heat sensitive phenotype of Scer\GAL4GMR.PF, Zzzz\CGG90.UAS.EGFP

      (Todd et al., 2010)

      HDAC6RNAi.UAS, Scer\GAL4GMR.PF is an enhancer of ommatidium | heat sensitive phenotype of Scer\GAL4GMR.PF, Zzzz\CGG90.UAS.EGFP

      (Todd et al., 2010)

      HDAC6RNAi.UAS, Scer\GAL4GMR.PF is an enhancer of interommatidial bristle | heat sensitive phenotype of Scer\GAL4GMR.PF, Zzzz\CGG90.UAS.EGFP

      (Todd et al., 2010)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference

      Co-expression of HDAC6dsRNA.Scer\UAS enhances the Scer\GAL4GMR.PF>Zzzz\CGG90.Scer\UAS.T:Avic\GFP-EGFP-induced rough-eye phenotype.

      (Todd et al., 2010)
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Used to study the phenotypic consequences of dsRNA interference (RNAi) of the HDAC6 gene.

      (Pandey et al., 2007)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HDAC6RNAi.UAS
      HDAC6dsRNA.Scer\UAS
      HDAC6dsRNA.UAS
      dHDAC6KD
      (Pandey et al., 2007)
      Name Synonyms
      Secondary FlyBase IDs
        References (4)