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FB2021_04, released August 17, 2021

Gene: Dmel\HDAC6

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General Information
Symbol
Dmel\HDAC6
Species
D. melanogaster
Name
Histone deacetylase 6
Annotation Symbol
CG6170
Feature Type
protein_coding_gene
FlyBase ID
FBgn0026428
Gene Model Status
Current
Stock Availability
15 publicly available
Enzyme Name (EC)
Acyl-lysine deacylase (3.5.1.17)
Histone deacetylase (3.5.1.98)
Gene Summary
Histone deacetylase 6 (HDAC6) encodes a cytosolic deacetylase that functions as a key modulator of proteostasis by mediating ubiquitin-proteasomal and lysosomal degradation of native and/or misfolded proteins. [Date last reviewed: 2018-09-27] (FlyBase Gene Snapshot)
All Summaries
Also Known As

dHDAC6, HDAC2, HDAC, dHDAC2

Key Links
Genomic Location
Cytogenetic map
13B6-13B6
Sequence location
X:15,333,310..15,340,360 [+]
Recombination map
1-50
RefSeq locus
NC_004354 REGION:15333310..15340360
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
GO Summary Ribbons
Gene Ontology (GO) Annotations (9 terms)
Molecular Function (4 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables deacetylase activity
inferred from mutant phenotype
(Miskiewicz et al., 2014)
enables histone deacetylase activity
inferred from direct assay
(Cho et al., 2005, Barlow et al., 2001)
inferred from mutant phenotype
(Feller et al., 2015)
Terms Based on Predictions or Assertions (2 terms)
CV Term
Evidence
References
enables NAD-independent histone deacetylase activity
non-traceable author statement
(Feller et al., 2015)
enables zinc ion binding
inferred from electronic annotation with InterPro:IPR001607
(assigned by InterPro )
(FlyBase Curators et al., 2004-)
Biological Process (4 terms)
Terms Based on Experimental Evidence (4 terms)
CV Term
Evidence
References
involved_in histone deacetylation
inferred from direct assay
(Barlow et al., 2001)
inferred from mutant phenotype
(Feller et al., 2015)
involved_in neurotransmitter secretion
inferred from mutant phenotype
(Miskiewicz et al., 2014)
involved_in protein deacetylation
inferred from direct assay
(Yan et al., 2017)
involved_in regulation of transcription, DNA-templated
inferred from direct assay
(Cho et al., 2005)
Terms Based on Predictions or Assertions (0 terms)
Cellular Component (1 term)
Terms Based on Experimental Evidence (1 term)
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Cho et al., 2005)
Terms Based on Predictions or Assertions (0 terms)
Gene Group (FlyBase)
Protein Family (UniProt)
-
Protein Signatures (InterPro)
Catalytic Activity (EC)
Experimental Evidence
Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone (3.5.1.98)
Predictions / Assertions
N(6)-acyl-L-lysine + H(2)O = a carboxylate + L-lysine (3.5.1.17)
Summaries
Gene Snapshot
Histone deacetylase 6 (HDAC6) encodes a cytosolic deacetylase that functions as a key modulator of proteostasis by mediating ubiquitin-proteasomal and lysosomal degradation of native and/or misfolded proteins. [Date last reviewed: 2018-09-27]
Gene Group (FlyBase)
RPD3/HDA1 LYSINE DEACETYLASES -
The RPD3/HDA1 family are Zn2+-dependent lysine deacetylases that share a common catalytic core domain. (Adapted from FBrf0159755).
Summary (Interactive Fly)

a microtubule-associated deacetylase - interacts with polyubiquitinated proteins to stimulate autophagy as a compensatory degradation system when the ubiquitin-proteasome system is impaired

Gene Model and Products
Number of Transcripts
7
Number of Unique Polypeptides
7

Please see the JBrowse view of Dmel\HDAC6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Comments on Gene Model

Stop-codon suppression (UGA) postulated; FBrf0216884.

Gene model reviewed during 5.44

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene
gene_with_stop_codon_read_through
(Jungreis et al., 2011)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
HDAC6-RA
FBtr0074008
NM_132789
4483
1128
HDAC6-RB
FBtr0074010
NM_167436
3848
1135
HDAC6-RC
FBtr0074009
NM_167437
4241
1138
HDAC6-RD
FBtr0301774
NM_001169289
3451
883
HDAC6-RE
FBtr0307383
NM_001258751
3817
1108
HDAC6-RF
FBtr0307384
NM_001258752
3272
1022
HDAC6-RG
FBtr0330405
NM_001272640
4483
1179
Additional Transcript Data and Comments
Reported size (kB)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
RefSeq ID
GenBank
HDAC6-PA
FBpp0073825
124.9
1128
6.45
NP_573017
AAF48443
HDAC6-PB
FBpp0073827
125.8
1135
6.45
NP_727842
AAN09661
HDAC6-PC
FBpp0073826
126.0
1138
6.45
NP_727843
AAN09662
HDAC6-PD
FBpp0290988
98.3
883
6.46
NP_001162760
ACZ95295
HDAC6-PE
FBpp0298372
122.6
1108
6.32
NP_001245680
AFH07394
HDAC6-PF
FBpp0298373
113.3
1022
6.85
NP_001245681
AFH07395
HDAC6-PG
FBpp0303431
130.8
1179
6.50
NP_001259569
AGB95411
Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments
Reported size (kDa)
Comments
External Data
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HDAC6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Expression Summary Ribbons
Colored tiles in ribbon indicate that expression data has been curated by FlyBase for that anatomical location. Colorless tiles indicate that there is no curated data for that location.
For complete stage-specific expression data, view the modENCODE Development RNA-Seq section under High-Throughput Expression below.
Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 11 -- 12
organism | faint | ubiquitous
(Fisher et al., 2012)
embryonic stage 13 -- 16
organism | faint | ubiquitous
(Fisher et al., 2012)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
Additional Descriptive Data
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in cytoplasm
inferred from direct assay
(Cho et al., 2005)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

GBrowse - Visual display of RNA-Seq signals

View Dmel\HDAC6 in GBrowse 2
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB
EMBL-EBI Single Cell Expression Atlas
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 7 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 17 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of HDAC6
Transgenic constructs containing regulatory region of HDAC6
Aberrations (Deficiencies and Duplications) ( 0 )
Alleles Representing Disease-Implicated Variants
Phenotypes
For more details about a specific phenotype click on the relevant allele symbol.
Lethality
Allele
lethal, with Scer\GAL4Tub.PU
viable
viable, with Scer\GAL4Mef2.PR
Sterility
Allele
fertile
fertile, with Scer\GAL4Mef2.PR
Other Phenotypes
Allele
abnormal neurophysiology
abnormal neurophysiology, with Scer\GAL4nSyb.PU
abnormal touch perception
abnormal touch perception (with Df(3L)BSC113)
abnormal touch response | larval stage
abnormal touch response | larval stage (with Df(3L)BSC113)
visible | adult stage, with Scer\GAL4en.PU
visible | adult stage | progressive, with Scer\GAL4GMR.PU
Phenotype manifest in
Allele
centriole
cytoplasmic microtubule | third instar larval stage
cytoplasmic microtubule | third instar larval stage | conditional, with Scer\GAL4C57
embryonic/larval somatic muscle | third instar larval stage
embryonic/larval somatic muscle | third instar larval stage | conditional, with Scer\GAL4C57
eye | adult stage | progressive, with Scer\GAL4GMR.PU
spermatid axoneme | P-stage
spermatozoon
synapse
synapse, with Scer\GAL4Act.PU
synaptic vesicle
synaptic vesicle, with Scer\GAL4Act.PU
t-bar
t-bar, with Scer\GAL4Act.PU
wing disc | third instar larval stage
wing vein, with Scer\GAL4en.PU
Orthologs
Downloads
Download All DIOPT Orthologs
Download All OrthoDB Orthologs
Human Orthologs (via DIOPT v8.0)
Homo sapiens (Human) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Hsap\HDAC6
14 of 15
Yes
Yes
3  
Hsap\HDAC10
7 of 15
No
Yes
1  
Hsap\HDAC4
4 of 15
No
No
8  
Hsap\HDAC5
4 of 15
No
No
Hsap\HDAC7
3 of 15
No
No
Hsap\HDAC9
3 of 15
No
No
Hsap\HDAC1
1 of 15
No
No
Hsap\HDAC2
1 of 15
No
No
Hsap\HDAC3
1 of 15
No
No
Hsap\HDAC8
1 of 15
No
No
Hsap\HDAC11
1 of 15
No
No
Hsap\USP3
1 of 15
No
No
Hsap\USP22
1 of 15
No
No
Hsap\USP27X
1 of 15
No
No
Hsap\USP30
1 of 15
No
No
3  
Hsap\USP44
1 of 15
No
Yes
Hsap\USP49
1 of 15
No
Yes
Hsap\USP51
1 of 15
No
No
Model Organism Orthologs (via DIOPT v8.0)
Mus musculus (laboratory mouse) (18)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
eggNOG
Hieranoid
Homologene
Inparanoid
Isobase
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
RoundUp
TreeFam
ZFIN
Alignment
Complementation?
Transgene?
Mmus\Hdac6
14 of 15
Yes
Yes
Mmus\Hdac10
7 of 15
No
Yes
Mmus\Hdac7
5 of 15
No
No
Mmus\Hdac5
4 of 15
No
No
Mmus\Hdac4
3 of 15
No
No
Mmus\Hdac9
2 of 15
No
No
Mmus\Hdac1
1 of 15
No
No
Mmus\Hdac2
1 of 15
No
No
Mmus\Hdac3
1 of 15
No
No
Mmus\Hdac8
1 of 15
No
No
Mmus\Hdac11
1 of 15
No
No
Mmus\Usp3
1 of 15
No
No
Mmus\Usp22
1 of 15
No
No
Mmus\Usp27x
1 of 15
No
No
Mmus\Usp30
1 of 15
No
No
Mmus\Usp44
1 of 15
No
Yes
Mmus\Usp49
1 of 15
No
No
Mmus\Usp51
1 of 15
No
No
Rattus norvegicus (Norway rat) (20)
Rnor\Hdac6
6 of 13
Yes
Yes
Rnor\LOC103689963
6 of 13
Yes
Yes
Rnor\Hdac10
4 of 13
No
Yes
Rnor\Hdac4
3 of 13
No
No
Rnor\Hdac9
3 of 13
No
No
Rnor\Hdac5
2 of 13
No
No
Rnor\Hdac1l
1 of 13
No
No
Rnor\Hdac1
1 of 13
No
No
Rnor\Hdac2
1 of 13
No
No
Rnor\Hdac3
1 of 13
No
No
Rnor\Hdac7
1 of 13
No
No
Rnor\Hdac8
1 of 13
No
No
Rnor\Hdac11
1 of 13
No
No
Rnor\LOC102552384
1 of 13
No
Yes
Rnor\LOC108348065
1 of 13
No
Yes
Rnor\Usp3
1 of 13
No
No
Rnor\Usp22
1 of 13
No
No
Rnor\Usp30
1 of 13
No
No
Rnor\Usp49
1 of 13
No
Yes
Rnor\Usp51
1 of 13
No
No
Xenopus tropicalis (Western clawed frog) (15)
Xtro\hdac6
11 of 12
Yes
Yes
Xtro\hdac4
2 of 12
No
No
Xtro\hdac7
2 of 12
No
No
Xtro\hdac10
2 of 12
No
Yes
Xtro\hdac1
1 of 12
No
No
Xtro\hdac2
1 of 12
No
No
Xtro\hdac3
1 of 12
No
No
Xtro\hdac5
1 of 12
No
Yes
Xtro\hdac8
1 of 12
No
No
Xtro\hdac9
1 of 12
No
No
Xtro\usp3
1 of 12
No
No
Xtro\usp22
1 of 12
No
No
Xtro\usp30
1 of 12
No
No
Xtro\usp44
1 of 12
No
Yes
Xtro\usp49
1 of 12
No
Yes
Danio rerio (Zebrafish) (15)
Drer\hdac6
13 of 15
Yes
Yes
Drer\hdac10
6 of 15
No
Yes
Drer\hdac5
4 of 15
No
No
Drer\hdac4
3 of 15
No
No
Drer\hdac7b
3 of 15
No
No
Drer\hdac9b
2 of 15
No
No
Drer\hdac1
1 of 15
No
No
Drer\hdac3
1 of 15
No
No
Drer\hdac7a
1 of 15
No
No
Drer\hdac11
1 of 15
No
No
Drer\phka1a
1 of 15
No
No
Drer\usp3
1 of 15
No
No
Drer\usp30
1 of 15
No
No
Drer\usp44
1 of 15
No
Yes
Drer\usp49
1 of 15
No
Yes
Caenorhabditis elegans (Nematode, roundworm) (12)
Cele\hda-6
14 of 15
Yes
Yes
Cele\hda-10
5 of 15
No
Yes
Cele\hda-4
4 of 15
No
No
Cele\hda-5
4 of 15
No
Yes
Cele\F43G6.17
3 of 15
No
Yes
Cele\C34F6.9
1 of 15
No
Yes
Cele\F43G6.4
1 of 15
No
No
Cele\hda-1
1 of 15
No
No
Cele\hda-2
1 of 15
No
No
Cele\hda-11
1 of 15
No
No
Cele\usp-3
1 of 15
No
No
Cele\Y67D2.2
1 of 15
No
No
Arabidopsis thaliana (thale-cress) (6)
Atha\HDA05
4 of 9
Yes
Yes
Atha\HDA18
4 of 9
Yes
Yes
Atha\HDA15
3 of 9
No
Yes
Atha\HDA08
2 of 9
No
Yes
Atha\HDA14
2 of 9
No
Yes
Atha\AT5G61050
1 of 9
No
Yes
Saccharomyces cerevisiae (Brewer's yeast) (7)
Scer\HDA1
9 of 15
Yes
Yes
Scer\HOS1
1 of 15
No
No
Scer\HOS2
1 of 15
No
No
Scer\HOS3
1 of 15
No
Yes
Scer\RPD3
1 of 15
No
No
Scer\UBP1
1 of 15
No
No
Scer\UBP8
1 of 15
No
No
Schizosaccharomyces pombe (Fission yeast) (1)
Spom\clr3
5 of 12
Yes
Yes
Ortholog(s) in Drosophila Species (via OrthoDB v9.1) ( EOG091901DR )
Organism
Common Name
Gene
AAA Syntenic Ortholog
Multiple Dmel Genes in this Orthologous Group
Drosophila suzukii
Spotted wing Drosophila
Dsuz\DS10_00006233
Drosophila simulans
Dsim\HDAC6
Drosophila sechellia
Dsec\GM20078
Drosophila erecta
Dere\GG17876
Drosophila yakuba
Dyak\GE17180
Drosophila ananassae
Dana\GF21044
Drosophila pseudoobscura pseudoobscura
Dpse\GA19406
Drosophila persimilis
Dper\GL14573
Drosophila willistoni
Dwil\GK20022
Drosophila virilis
Dvir\GJ17051
Drosophila mojavensis
Dmoj\GI15174
Drosophila grimshawi
Dgri\GH17575
Orthologs in non-Drosophila Dipterans (via OrthoDB v9.1) ( EOG091500SN )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Musca domestica
House fly
Mdoa\17019295
Glossina morsitans
Tsetse fly
Gmor\GMOY000484
Glossina morsitans
Tsetse fly
Gmor\GMOY001287
Lucilia cuprina
Australian sheep blowfly
Lcup\FF38_14519
Mayetiola destructor
Hessian fly
Mdes\Mdes013382
Mayetiola destructor
Hessian fly
Mdes\Mdes003277
Aedes aegypti
Yellow fever mosquito
Aaeg\AAEL001069
Anopheles darlingi
American malaria mosquito
Adar\ADAC000499
Anopheles gambiae
Malaria mosquito
Agam\AGAP000532
Culex quinquefasciatus
Southern house mosquito
Cqui\CPIJ012311
Orthologs in non-Dipteran Insects (via OrthoDB v9.1) ( EOG090W00ZS )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Bombyx mori
Silkmoth
Bmor\BGIBMGA005759
Danaus plexippus
Monarch butterfly
Dple\DPOGS215725-PA
Heliconius melpomene
Postman butterfly
Hmel\HMEL009651
Apis florea
Little honeybee
Aflo\2544973540
Apis mellifera
Western honey bee
Amel\GB42847
Apis mellifera
Western honey bee
Amel\GB48093
Bombus impatiens
Common eastern bumble bee
Bimp\BIMP25351
Bombus terrestris
Buff-tailed bumblebee
Bter\15207308
Linepithema humile
Argentine ant
Lhum\LH16185
Megachile rotundata
Alfalfa leafcutting bee
Mrot\MROTU:003153
Nasonia vitripennis
Parasitic wasp
Nvit\Nasvi2EG024980
Dendroctonus ponderosae
Mountain pine beetle
Dpod\YQE_05972
Tribolium castaneum
Red flour beetle
Tcas\TC014236
Pediculus humanus
Human body louse
Phum\PHUM538580
Rhodnius prolixus
Kissing bug
Rpro\RPRC001230
Rhodnius prolixus
Kissing bug
Rpro\RPRC009648
Cimex lectularius
Bed bug
Clec\CLEC009419
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI003736
Acyrthosiphon pisum
Pea aphid
Apim\ACYPI002334
Zootermopsis nevadensis
Nevada dampwood termite
Znev\Znev_02211
Orthologs in non-Insect Arthropods (via OrthoDB v9.1) ( EOG090X00Y1 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Stegodyphus mimosarum
African social velvet spider
Smim\KFM80510.1
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05190
Tetranychus urticae
Two-spotted spider mite
Turt\tetur02g05660
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_194595
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_308757
Daphnia pulex
Water flea
Dpux\DAPPUDRAFT_98501
Orthologs in non-Arthropod Metazoa (via OrthoDB v9.1) ( EOG091G0210 )
Organism
Common Name
Gene
Multiple Dmel Genes in this Orthologous Group
Strongylocentrotus purpuratus
Purple sea urchin
Spur\Sp-Hdac6
Gallus gallus
Domestic chicken
Ggal\ENSGALG00000008641
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v8.0)
Drosophila melanogaster (Fruit fly) (6)
Gene Symbol
Score
Source
Compara
eggNOG
Homologene
Inparanoid
Isobase
OrthoDB
OrthoFinder
orthoMCL
Panther
RoundUp
Alignment
HDAC4
5 of 10
HDAC1
2 of 10
HDAC3
2 of 10
HDAC11
2 of 10
not
1 of 10
Usp30
1 of 10
Human Disease Associations
FlyBase Human Disease Model Reports
Disease Model Summary Ribbon
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 1 )
Allele
Disease
Evidence
References
HDAC6KO
model of  obesity
CEA
(Yan et al., 2017)
Potential Models Based on Orthology ( 1 )
Modifiers Based on Experimental Evidence ( 7 )
Disease Associations of Human Orthologs (via DIOPT v8.0 and OMIM)
Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
Homo sapiens (Human)
Gene name
Score
OMIM
OMIM Phenotype
DO term
Complementation?
Transgene?
HDAC6; histone deacetylase 6
14 of 15
300272
 
HDAC10; histone deacetylase 10
7 of 15
608544
       
      HDAC4; histone deacetylase 4
      4 of 15
      605314
           
          HDAC5; histone deacetylase 5
          4 of 15
          605315
              HDAC7; histone deacetylase 7
              3 of 15
              606542
                  HDAC9; histone deacetylase 9
                  3 of 15
                  606543
                      Functional Complementation Data
                      Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                      Interactions
                      Summary of Physical Interactions
                      esyN Network Diagram
                      Show neighbor-neighbor interactions:
                      Select Layout:
                      Legend:
                      Protein
                      RNA
                      Selected Interactor(s)
                      Interactions Browser
                      View in Interactions Browser
                      Please see the Physical Interaction reports below for full details
                      RNA-protein
                      Physical Interaction
                      Assay
                      References
                      HDAC6 - TBPH
                      anti tag coimmunoprecipitation, primer specific pcr
                      (Godena et al., 2011)
                      protein-protein
                      Physical Interaction
                      Assay
                      References
                      HDAC6 - Hsap\SNCA
                      anti bait coimmunoprecipitation, western blot
                      (Du et al., 2010)
                      HDAC6 - Hsc70-4
                      anti tag coimmunoprecipitation, anti tag western blot, enzymatic study, autoradiography
                      (Yan et al., 2017)
                      HDAC6 - Ufm1
                      anti tag coimmunoprecipitation, peptide massfingerprinting, experimental knowledge based
                      (Rhee et al., 2014)
                      Summary of Genetic Interactions
                      esyN Network Diagram
                      esyN Network Key:
                      Suppression
                      Enhancement
                      View in Interactions Browser
                      Please look at the allele data for full details of the genetic interactions
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      HDAC6
                      enhanceable
                      htt
                      (Dietz et al., 2015)
                      Starting gene(s)
                      Interaction type
                      Interacting gene(s)
                      Reference
                      anne
                      suppressible
                      HDAC6
                      (Wang et al., 2019)
                      Cep97
                      suppressible
                      HDAC6
                      (Dobbelaere et al., 2020)
                      Kat60
                      suppressible
                      HDAC6
                      (Mao et al., 2014)
                      Prosβ2
                      suppressible
                      HDAC6
                      (Pandey et al., 2007)
                      Sirt2
                      enhanceable
                      HDAC6
                      (Dobbelaere et al., 2020)
                      Sirt2
                      suppressible
                      HDAC6
                      (Dobbelaere et al., 2020)
                      External Data
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Pathways
                      Signaling Pathways (FlyBase)
                      Metabolic Pathways
                      External Data
                      Linkouts
                      Genomic Location and Detailed Mapping Data
                      Chromosome (arm)
                      X
                      Recombination map
                      1-50
                      Cytogenetic map
                      13B6-13B6
                      Sequence location
                      X:15,333,310..15,340,360 [+]
                      FlyBase Computed Cytological Location
                      Cytogenetic map
                      Evidence for location
                      13B6-13B6
                      Limits computationally determined from genome sequence between P{EP}hiwEP1308 and P{EP}Ahcy13EP1007
                      Experimentally Determined Cytological Location
                      Cytogenetic map
                      Notes
                      References
                      13B-13B
                      (Barlow, 1999.2.18)
                      Experimentally Determined Recombination Data
                      Location

                      1-50

                      (FlyBase, 2016)

                      1-50.6

                      (Comeron et al., 2012)
                      Left of (cM)
                      Right of (cM)
                      Notes
                      Stocks and Reagents
                      Stocks (15)
                      Genomic Clones (11)
                       

                      Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

                      cDNA Clones (83)
                       

                      Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.

                      cDNA clones, fully sequenced
                      BDGP DGC clones
                      Other clones
                      Drosophila Genomics Resource Center cDNA clones

                      For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                      cDNA Clones, End Sequenced (ESTs)
                      BDGP DGC clones
                      Other clones
                      RNAi and Array Information
                      Linkouts
                      DRSC - Results frm RNAi screens
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      Antibody Information
                      Laboratory Generated Antibodies
                       

                      polyclonal

                      (Chen et al., 2008)
                      Commercially Available Antibodies
                       
                      Other Information
                      Relationship to Other Genes
                      Source for database identify of

                      Source for identity of: HDAC2 CG6170

                      (Wang, 1999.11)
                      Source for database merge of
                      Additional comments
                      Other Comments

                      HDAC6 regulates T-bar morphology.

                      (Miskiewicz et al., 2014)

                      Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.

                      (Liu and Lehmann, 2008)

                      S2 cells which have been treated with dsRNA made from templates generated with primers directed against HDAC6 show no significant inhibition of cell growth.

                      (Foglietti et al., 2006)

                      The HDAC6 gene can be spliced into two isoforms, HDAC6-S, and HDAC6-L, containing 883 and 1128 amino acids, respectively. These isoforms are identical except that HDAC6-L has an additional 75 amino acids at the N terminus and 170 amino acids at the C terminus containing a ubiquitin binding protein domain.

                      (Cho et al., 2005)
                      Origin and Etymology
                      Discoverer
                      Etymology
                      Identification
                      External Crossreferences and Linkouts ( 96 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DRscDB
                      EMBL-EBI Single Cell Expression Atlas
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      GenomeRNAi - A database for cell-based and in vivo RNAi phenotypes and reagents
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL
                      modMine - A data warehouse for the modENCODE project
                      Linkouts
                      BioGRID - A database of protein and genetic interactions.
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      FlyMine - An integrated database for Drosophila genomics
                      Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Synonyms and Secondary IDs (15)
                      Reported As
                      Symbol Synonym
                      CG6170
                      (Meadows, 2017.1.11, Çiçek et al., 2016, Ni et al., 2011.7.19, Keleman et al., 2009.8.5, Chen et al., 2008, Ni et al., 2008, Grieder et al., 2007, Foglietti et al., 2006)
                      DHDAC2
                      (Foglietti et al., 2006)
                      DmHDAC2
                      (Chen and Courey, 2000)
                      HDAC
                      (Padmanabhan et al., 2006, Guenther and Lazar, 2001, Jones and Kadonaga, 2000)
                      HDAC2
                      (Beaver et al., 2020, Zhang et al., 2020, Milon et al., 2012)
                      HDAC6
                      (Keegan and Hughes, 2021, Layalle et al., 2021, Yamaguchi et al., 2021, Haudry et al., 2020, Jeon et al., 2020, Kang et al., 2020, Kankel et al., 2020, Vargas et al., 2020, Engel et al., 2019, Meltzer et al., 2019, Rodriguez-Fernandez et al., 2019, Sang Cho et al., 2019, Shimaji et al., 2019, Suda et al., 2019, Wang et al., 2019, Gene Disruption Project members, 2018-, Liu et al., 2018, Yan et al., 2018, Mohr et al., 2017, Perry et al., 2017, Transgenic RNAi Project members, 2017-, Yan et al., 2017, Hirano et al., 2016, Sarov et al., 2016, Schwartz et al., 2016, Aradska et al., 2015, Casci and Pandey, 2015, Dietz et al., 2015, Duncker et al., 2015, Nikalayevich and Ohkura, 2015, Godena et al., 2014, Ho et al., 2014, Mao et al., 2014, Miskiewicz et al., 2014, Mulakkal et al., 2014, Slattery et al., 2014, Zhang et al., 2014, Puram and Bonni, 2013, Rallis et al., 2013, Xiong et al., 2013, Meijering et al., 2012, Pushpavalli et al., 2012, Romano et al., 2012, Jungreis et al., 2011, Miśkiewicz et al., 2011, Nègre et al., 2011, Blanco et al., 2010, Fiesel et al., 2010, Lee et al., 2010, Todd et al., 2010, Svetec et al., 2009, Chen et al., 2008, Liu and Lehmann, 2008, Pallos et al., 2008, Pandey et al., 2007, Cho et al., 2005)
                      Hdac6
                      (Dobbelaere et al., 2020)
                      dHDAC2
                      (Taylor-Harding et al., 2004, Mallin et al., 2000)
                      dHDAC6
                      (Wang et al., 2019, Muñoz-Soriano and Paricio, 2011, Du et al., 2010, Lee et al., 2010, Todd et al., 2010, Pandey et al., 2007, Kim et al., 2005, Taylor-Harding et al., 2004, Barlow et al., 2001)
                      dmHDA404
                      (Pandey et al., 2002)
                      hdac6
                      (Tsakiri et al., 2019, Gupta et al., 2016, Godena et al., 2011)
                      Name Synonyms
                      HDAC6
                      Histone Deacetylase 6
                      (Du et al., 2010)
                      Histone deacetylase 6
                      histone deacetylase 6
                      (Lee et al., 2014, Mulakkal et al., 2014, Muñoz-Soriano and Paricio, 2011, Fiesel et al., 2010, Todd et al., 2010)
                      histone deacetylase HDA2
                      (Barlow, 1999.2.18)
                      Secondary FlyBase IDs
                        Datasets (1)
                        Study focus (1)
                        Experimental Role
                        Project
                        Project Type
                        Title
                        • bait_protein
                        modENCODE_regulation_chromatin
                        Genome-wide localization of chromatin factors by ChIP-chip and ChIP-Seq.
                        References (120)