dHDAC6, HDAC2, HDAC, dHDAC2
a microtubule-associated deacetylase - interacts with polyubiquitinated proteins to stimulate autophagy as a compensatory degradation system when the ubiquitin-proteasome system is impaired
Stop-codon suppression (UGA) postulated; FBrf0216884.
Gene model reviewed during 5.44
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.50
None of the polypeptides share 100% sequence identity.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\HDAC6 using the Feature Mapper tool.
GBrowse - Visual display of RNA-Seq signalsView Dmel\HDAC6 in GBrowse 2
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see GBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
Source for identity of: HDAC2 CG6170
Gene expression is increased in response to the presence of two copies of Scer\GAL4hs.PB.
S2 cells which have been treated with dsRNA made from templates generated with primers directed against HDAC6 show no significant inhibition of cell growth.
The HDAC6 gene can be spliced into two isoforms, HDAC6-S, and HDAC6-L, containing 883 and 1128 amino acids, respectively. These isoforms are identical except that HDAC6-L has an additional 75 amino acids at the N terminus and 170 amino acids at the C terminus containing a ubiquitin binding protein domain.