FB2026_02 , released June 18, 2026

CV Term Report

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General Information

Term

histone H4K12 deacetylase activity, hydrolytic mechanism

ID (Ontology)

GO:0140937 (Gene Ontology)

Definition

Catalysis of the reaction: histone H4 N6-acetyl-L-lysine (position 12) + H2O = histone H4 L-lysine (position 12) + acetate. This reaction represents the removal of an acetyl group from lysine at position 12 of the histone H4 protein.[ PubMed:15293224 ]

Also Known As

"histone deacetylase activity (H4-K12 specific)" ; "histone H4-K12 deacetylase activity"

Comment

Links to External Ontologies

QuickGO data AmiGO data

Annotations

Records annotated with this term OR any of its CHILD TERMS

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Direct annotations: records annotated with this exact term (child terms are NOT included)

Data Class	Field	Direct annotations
Genes (FBgn)	GO_MOLECULAR_FUNCTION

Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records

Full annotation statements	Relevant FlyBase reports
Full annotation statements	Genes
histone H4K12 deacetylase activity, hydrolytic mechanism (all annotations which use CV term, excluding "NOT" statements)
enables \| histone H4K12 deacetylase activity, hydrolytic mechanism

Spanning Tree (Parents/Children)

histone deacetylase activity
 |__histone H4K deacetylase activity_____________________________________________________
 |__histone deacetylase activity, hydrolytic mechanism___________________________________|
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides  |
 |__histone deacetylase activity, hydrolytic mechanism___________________________________|
                                                                                         histone H4K12 deacetylase activity, hydrolytic mechanism  3 rec.

Spanning Tree View Settings
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Relationships
Is a	histone H4K deacetylase activity histone deacetylase activity, hydrolytic mechanism
Part of
Synonyms & Secondary IDs
Synonyms
	"histone deacetylase activity (H4-K12 specific)" EXACT "histone H4-K12 deacetylase activity" EXACT "histone H4-K12 deacetylation" RELATED "histone H4K12 deacetylase activity" BROAD "histone H4K12 deacetylation" RELATED
Secondary IDs

External Crossreferences & Linkouts