FlyBase Allele Report: Dmel\HDAC6[UAS.cDa]

General Information

Symbol

Dmel\HDAC6^UAS.cDa

Species

D. melanogaster

Name

FlyBase ID

FBal0248833

Feature type

allele

Associated gene

Dmel\HDAC6

Associated Insertion(s)

Carried in Construct

P{UAS-HDAC6.D}

Also Known As

UAS-HDAC6, HDAC6 OE

Key Links

Transgenic product class

wild_type

(Du et al., 2010)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Du et al., 2010)

Mutagen

in vitro construct

(Du et al., 2010)

Progenitor genotype

Carried in construct

P{UAS-HDAC6.D}

Cytology

Description

UASt regulatory sequences drive expression of the coding sequence of the HDAC6-RA isoform.

(Du et al., 2010)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

HDAC6

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cFa

(Du et al., 2010)

ameliorates obesity

modeled by Lsd-2^UAS.EYFP

(Yan et al., 2017)

ameliorates Kufor-Rakeb syndrome

modeled by anne^HM05242

(Wang et al., 2019)

ameliorates Alzheimer's disease 1

modeled by Hsap\APP^{Aβ42.UAS.Tag:SS(rPENK)}

(Cheng et al., 2022)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

The expression of HDAC6^UAS.cDa under the control of Scer\GAL4^Cg.PA does not affect the number of autophagosome-like structures (Atg8a-positive) in the early third instar larval fat body, as compared to controls.

(Liu et al., 2018)

Third instar larvae expressing HDAC6^Scer\UAS.cDa under the control of Scer\GAL4^C57 do not display any apparent differences in the microtubule network in muscle cells compared to controls at room temperature but their microtubules (MT) are more sensitive to cold-induced destabilization as the perinuclear MTs are much less dense in αTub84B^K40R mutant muscle cells than in wild-type after cold treatment.

(Mao et al., 2017)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

HDAC6^UAS.cDa, Scer\GAL4^elav-C155 is a suppressor | partially of abnormal locomotor behavior | adult stage phenotype of Scer\GAL4^elav-C155, anne^RNAi.UAS.cUa

(Wang et al., 2019)

HDAC6^UAS.cDa, Scer\GAL4^elav.PU is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Kat60^UAS.cMa, Scer\GAL4^elav.PU

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^C57 is a suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Kat60^UAS.cMa, Scer\GAL4^C57

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^ppk.PG is a suppressor of abnormal neuroanatomy phenotype of Kat60^UAS.cMa, Scer\GAL4^ppk.PG

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^GMR.PU is a suppressor of abnormal neuroanatomy | conditional | adult stage phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(Du et al., 2010)

NOT Suppressor of

Statement

Reference

HDAC6^UAS.cDa, Scer\GAL4^Cg.PA is a non-suppressor of decreased cell size | third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

Phenotype Manifest In

Suppressor of

Statement

Reference

HDAC6^UAS.cDa, Scer\GAL4^da.PU is a suppressor of adult brain phenotype of Scer\GAL4^da.PU, anne^RNAi.UAS.cUa

(Wang et al., 2019)

HDAC6^UAS.cDa, Scer\GAL4^da.PU is a suppressor of lysosome | adult stage phenotype of Scer\GAL4^da.PU, anne^RNAi.UAS.cUa

(Wang et al., 2019)

HDAC6^UAS.cDa, Scer\GAL4^elav-C155 is a suppressor of adult brain | progressive phenotype of Scer\GAL4^elav-C155, anne^RNAi.UAS.cUa

(Wang et al., 2019)

HDAC6^UAS.cDa, Scer\GAL4^Mhc.PK is a suppressor | partially of mesothoracic tergotrochanter muscle cell phenotype of Lsd-2^UAS.cUa, Scer\GAL4^Mhc.PK

(Yan et al., 2017)

HDAC6^UAS.cDa, Scer\GAL4^Mhc.PK is a suppressor | partially of lipid droplet | adult stage phenotype of Lsd-2^UAS.cUa, Scer\GAL4^Mhc.PK

(Yan et al., 2017)

HDAC6^UAS.cDa, Scer\GAL4^ppk.PG is a suppressor of dendritic tree phenotype of Kat60^UAS.cMa, Scer\GAL4^ppk.PG

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^C57 is a suppressor of microtubule phenotype of Kat60^UAS.cMa, Scer\GAL4^C57

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^elav.PU is a suppressor of NMJ bouton | third instar larval stage phenotype of Kat60^UAS.cMa, Scer\GAL4^elav.PU

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^C57 is a suppressor of NMJ bouton | third instar larval stage phenotype of Kat60^UAS.cMa, Scer\GAL4^C57

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^ppk.PG is a suppressor of larval multidendritic class IV neuron phenotype of Kat60^UAS.cMa, Scer\GAL4^ppk.PG

(Mao et al., 2014)

HDAC6^UAS.cDa, Scer\GAL4^GMR.PU is a suppressor of ommatidium | conditional phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(Du et al., 2010)

HDAC6^UAS.cDa, Scer\GAL4^GMR.PU is a suppressor of eye photoreceptor cell | conditional phenotype of Hsap\SNCA^UAS.cFa, Scer\GAL4^GMR.PU

(Du et al., 2010)

NOT Suppressor of

Statement

Reference

HDAC6^UAS.cDa, Scer\GAL4^Cg.PA is a non-suppressor of fat cell | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

HDAC6^UAS.cDa, Scer\GAL4^Cg.PA is a non-suppressor of autophagosome | early third instar larval stage phenotype of Scer\GAL4^Cg.PA, Tom40^JF02030

(Liu et al., 2018)

HDAC6^UAS.cDa, Scer\GAL4^C57 is a non-suppressor of microtubule phenotype of Scer\GAL4^C57, spas^UAS.cTa

(Mao et al., 2014)

Other

Statement

Reference

HDAC6^UAS.cDa, Hsc70-4^UAS.cEa, Scer\GAL4^Mhc.PK has mesothoracic tergotrochanter muscle cell phenotype

(Yan et al., 2017)

HDAC6^UAS.cDa, Hsc70-4^UAS.cEa, Scer\GAL4^Mhc.PK has lipid droplet | adult stage phenotype

(Yan et al., 2017)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of HDAC6^Scer\UAS.cDa completely rescues the increase in satellite boutons at the neuromuscular junction seen in third instar larvae expressing Kat60^Scer\UAS.cMa under the control of either Scer\GAL4^elav.PU or Scer\GAL4^C57.

Co-expression of HDAC6^Scer\UAS.cDa does not rescue the defects in dendritic elaboration in the class IV dendritic arborization neurons which are caused by expression of Kat60^Scer\UAS.cMa under the control of Scer\GAL4^ppk.PG.

Co-expression of HDAC6^Scer\UAS.cDa rescues the decrease in perinuclear microtubule density which is seen in larval muscle cells expressing Kat60^Scer\UAS.cMa under the control of Scer\GAL4^C57.

The decrease in perinuclear microtubule density which is seen in larval muscle cells expressing spas^Scer\UAS.cTa under the control of Scer\GAL4^C57 is not altered by co-expression of HDAC6^Scer\UAS.cDa.

(Mao et al., 2014)

Xenogenetic Interactions

Statement

Reference

Co-expression of HDAC6^Scer\UAS.cDa suppresses the retinal degeneration phenotype seen in adults expressing Hsap\SNCA^Scer\UAS.cFa under the control of Scer\GAL4^GMR.PU.

(Du et al., 2010)

Complementation and Rescue Data

Rescues

Scer\GAL4^Mhc.PK/HDAC6^UAS.cDa rescues HDAC6^KO

(Yan et al., 2017)

HDAC6^UAS.cDa/Scer\GAL4^C57 rescues HDAC6^KO

(Xiong et al., 2013)

Fails to rescue

HDAC6^UAS.cDa/Scer\GAL4^NP5440 fails to rescue HDAC6^KO

(Yan et al., 2017)

Comments

Expression of HDAC6^Scer\UAS.cDa under the control of Scer\GAL4^C57 completely suppresses the ability of HDAC6^KO to rescue the perinuclear microtubule density defects seen in the muscles of animals expressing either Hsap\MAPT^{V337M.Scer\UAS} under the control of Scer\GAL4^C57.

(Xiong et al., 2013)

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

51181

y¹ w^*; P{UAS-HDAC6.D}3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

HDAC6^Scer\UAS.cDa

HDAC6^UAS.cDa

Name Synonyms

Secondary FlyBase IDs

References (13)

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