FlyBase Allele Report: Dmel\HDAC6[HMS00077]

General Information

Symbol

Dmel\HDAC6^HMS00077

Species

D. melanogaster

Name

FlyBase ID

FBal0263085

Feature type

allele

Associated gene

Dmel\HDAC6

Associated Insertion(s)

Carried in Construct

P{TRiP.HMS00077}

Also Known As

HDAC6 RNAi

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Ni et al., 2011.7.19)

Mutagen

in vitro construct

(Ni et al., 2011.7.19)

Progenitor genotype

Carried in construct

P{TRiP.HMS00077}

Cytology

Description

UAS regulatory sequences drive expression of a short inverted repeat.

(Ni et al., 2011.7.19)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-HMS00077

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible | adult stage, with Scer\GAL4^en.PU

(Dietz et al., 2015)

Phenotype Manifest In

wing vein, with Scer\GAL4^en.PU

(Dietz et al., 2015)

Detailed Description

Statement

Reference

Expression of HDAC6^HMS00077 under the control of Scer\GAL4^en.PU leads to occasional ectopic wing veins, whereas expression controlled by any of the following: Scer\GAL4^ey.PH, Scer\GAL4^GMR.PF or Scer\GAL4^nub.PK has no overt adult phenotype. Scer\GAL4^Act5C.PI-driven expression is viable.

(Dietz et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

HDAC6^HMS00077, Scer\GAL4^en.PU has visible | adult stage phenotype, enhanceable by htt^GD14943, Scer\GAL4^en.PU

(Dietz et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

HDAC6^HMS00077, Scer\GAL4^en.PU has wing vein phenotype, enhanceable by htt^GD14943, Scer\GAL4^en.PU

(Dietz et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The wing vein phenotype phenotype induced by expression of HDAC6^HMS00077 under the control of Scer\GAL4^en.PU is weakly enhanced by co-expression of htt^GD14943.

(Dietz et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

34072