FB2026_03 , released September 17, 2026
FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term histone deacetylase activity ID (Ontology) GO:0004407 (Gene Ontology)
Definition Removal of an acetyl group from a lysine residue in a histone.[ PubMed:24691964 PubMed:9893272 ]
Also Known As "histone deacetylase activity (NAD-independent)"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 histone deacetylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | histone deacetylase activity       --
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deacetylase activity
 |__protein lysine deacetylase activity__
catalytic activity, acting on a protein  |
 |__protein lysine deacetylase activity__|
 |__histone modifying activity___________|
                                         histone deacetylase activity  13 rec.
                                          |__histone deacetylase activity, hydrolytic mechanism 6 rec.
                                          |   |__histone H3K4 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K9 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K14 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H4K5 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |   |__histone H4K8 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |   |__histone H4K12 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |   |__histone H4K16 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |__histone deacetylase activity, NAD-dependent 6 rec.
                                          |   |__histone H3K4 deacetylase activity, NAD-dependent
                                          |   |__histone H3K9 deacetylase activity, NAD-dependent 2 rec.
                                          |   |__histone H3K14 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K18 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K56 deacetylase activity, NAD-dependent
                                          |   |__histone H4K16 deacetylase activity, NAD-dependent 1 rec.
                                          |__histone H3K deacetylase activity 3 rec.
                                          |   |__histone H3K4 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K4 deacetylase activity, NAD-dependent
                                          |   |__histone H3K9 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K9 deacetylase activity, NAD-dependent 2 rec.
                                          |   |__histone H3K14 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K14 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K18 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K56 deacetylase activity, NAD-dependent
                                          |__histone H4K deacetylase activity 4 rec.
                                              |__histone H4K5 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K8 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K12 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K16 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K16 deacetylase activity, NAD-dependent 1 rec.
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Is a protein lysine deacetylase activity
histone modifying activity
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Synonyms
  • "histone deacetylase activity (NAD-independent)" EXACT
Secondary IDs
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Reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin"
Reactome:R-HSA-2545253 "Deacetylation of cohesin"
Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones"
Reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone"
Reactome:R-HSA-3782637 "HDAC8 deacetylates histones"
Reactome:R-HSA-3782655 "HDAC10 deacetylates histone"
Reactome:R-HSA-427514 "eNoSC deacetylates histone H3"
Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3"
Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53"