FB2026_02 , released June 18, 2026
FB2026_02 , released June 18, 2026
CV Term Report
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General Information
Term histone deacetylase activity ID (Ontology) GO:0004407 (Gene Ontology)
Definition Removal of an acetyl group from a lysine residue in a histone.[ PubMed:24691964 PubMed:9893272 ]
Also Known As "histone deacetylase activity (NAD-independent)"
Comment
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Annotations
Records annotated with this term OR any of its CHILD TERMS
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Records annotated with this exact term (annotations to child terms are NOT included)
Data Class Field Records
Genes (FBgn)  GO_MOLECULAR_FUNCTION       9
show Full annotation statements including this term (annotations to child terms are NOT included), and relevant FlyBase records
 Full annotation statements 
Relevant FlyBase reports
 Gene Groups Genes
 histone deacetylase activity (all annotations which use CV term, excluding "NOT" statements)       1      9
     enables | histone deacetylase activity       --       9
Spanning Tree (Parents/Children)
Only view relationship: 
deacetylase activity
 |__protein lysine deacetylase activity__
catalytic activity, acting on a protein  |
 |__protein lysine deacetylase activity__|
 |__histone modifying activity___________|
                                         histone deacetylase activity  13 rec.
                                          |__histone deacetylase activity, hydrolytic mechanism 6 rec.
                                          |   |__histone H3K4 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K9 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K14 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H4K5 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |   |__histone H4K8 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |   |__histone H4K12 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |   |__histone H4K16 deacetylase activity, hydrolytic mechanism 3 rec.
                                          |__histone deacetylase activity, NAD-dependent 6 rec.
                                          |   |__histone H3K4 deacetylase activity, NAD-dependent
                                          |   |__histone H3K9 deacetylase activity, NAD-dependent 2 rec.
                                          |   |__histone H3K14 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K18 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K56 deacetylase activity, NAD-dependent
                                          |   |__histone H4K16 deacetylase activity, NAD-dependent 1 rec.
                                          |__histone H3K deacetylase activity 3 rec.
                                          |   |__histone H3K4 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K4 deacetylase activity, NAD-dependent
                                          |   |__histone H3K9 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K9 deacetylase activity, NAD-dependent 2 rec.
                                          |   |__histone H3K14 deacetylase activity, hydrolytic mechanism
                                          |   |__histone H3K14 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K18 deacetylase activity, NAD-dependent 1 rec.
                                          |   |__histone H3K56 deacetylase activity, NAD-dependent
                                          |__histone H4K deacetylase activity 4 rec.
                                              |__histone H4K5 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K8 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K12 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K16 deacetylase activity, hydrolytic mechanism 3 rec.
                                              |__histone H4K16 deacetylase activity, NAD-dependent 1 rec.
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Is a protein lysine deacetylase activity
histone modifying activity
Part of
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Synonyms
  • "histone deacetylase activity (NAD-independent)" EXACT
Secondary IDs
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Reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin"
Reactome:R-HSA-2545253 "Deacetylation of cohesin"
Reactome:R-HSA-3769447 "HDAC1:2-containing complex deacetylate histones"
Reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone"
Reactome:R-HSA-3782637 "HDAC8 deacetylates histones"
Reactome:R-HSA-3782655 "HDAC10 deacetylates histone"
Reactome:R-HSA-427514 "eNoSC deacetylates histone H3"
Reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3"
Reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53"
Reactome:R-HSA-9941704 "NuRD deacetylates telomeric nucleosomes"
Reactome:R-HSA-9944092 "NuRD deacetylates nucleosomes"