FlyBase Allele Report: Dmel\HDAC6[JF01501]

FB2026_01 , released March 12, 2026

FB2026_01 , released March 12, 2026

Allele: Dmel\HDAC6^JF01501

General Information

Symbol

Dmel\HDAC6^JF01501

Species

D. melanogaster

Name

FlyBase ID

FBal0245762

Feature type

allele

Associated gene

Associated Insertion(s)

Carried in Construct

P{TRiP.JF01501}

Also Known As

HDAC6^RNAi, HDAC6 RNAi

Key Links

Genomic Maps

Transgenic product class

(Ni et al., 2008)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

(Ni et al., 2008)

Mutagen

in vitro construct

(Ni et al., 2008)

Progenitor genotype

Carried in construct

P{TRiP.JF01501}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Ni et al., 2008)

Allele components

Component

Use(s)

Regulatory region(s)

binary expression system - regulatory region

Encoded product / tool

Also carries

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 2

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

ameliorates autosomal dominant distal hereditary motor neuronopathy 3

modeled by Hsap\HSPB1^S135F.UAS

(Kang et al., 2020)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

decreased cell number | oogenesis, with Scer\GAL4^nanos.PU

(Sun et al., 2023)

Phenotype Manifest In

cystoblast | decreased number, with Scer\GAL4^nanos.PU

(Sun et al., 2023)

female germline stem cell | decreased number, with Scer\GAL4^nanos.PU

(Sun et al., 2023)

Detailed Description

Statement

Reference

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

HDAC6^JF01501, Scer\GAL4^GMR.PU is a suppressor | partially of visible | adult stage | progressive phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

Phenotype Manifest In

Suppressor of

Statement

Reference

HDAC6^JF01501, Scer\GAL4^GMR.PU is a suppressor of eye phenotype of Scer\GAL4^GMR.PU, Zzzz\GGGGCC^30.UAS.EGFP

(Kankel et al., 2020)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

31053

y¹ v¹; P{TRiP.JF01501}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

HDAC6^JF01501

HDAC6^RNAi

(Jugder et al., 2021)

Name Synonyms

Secondary FlyBase IDs

References (11)

Report Sections