FB2026_03 , released September 17, 2026
CV Term Report
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General Information
Term protein lysine deacetylase activity ID (Ontology) GO:0033558 (Gene Ontology)
Definition Catalysis of the reaction: Removal of an acetyl group from a lysine residue in a protein.[ PubMed:27296530 ]
Also Known As"protein deacetylase activity"
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Data ClassFieldDirect annotations
Genes (FBgn)GO_MOLECULAR_FUNCTION
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 Genes
 protein lysine deacetylase activity (all annotations which use CV term, excluding "NOT" statements)
     enables | protein lysine deacetylase activity
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catalytic activity
 |__catalytic activity, acting on a protein__
deacylase activity                           |
 |__deacetylase activity_____________________|
                                             protein lysine deacetylase activity  13 rec.
                                              |__histone deacetylase activity 13 rec.
                                              |   |__histone deacetylase activity, hydrolytic mechanism(+) 6 rec.
                                              |   |__histone deacetylase activity, NAD-dependent(+) 6 rec.
                                              |   |__histone H3K deacetylase activity(+) 3 rec.
                                              |   |__histone H4K deacetylase activity(+) 4 rec.
                                              |__tubulin deacetylase activity
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Is a deacetylase activity
catalytic activity, acting on a protein
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Synonyms
  • "protein deacetylase activity" EXACT
Secondary IDs
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Reactome:R-HSA-5693092 "Unknown deacetylase deacetylates 7K-BACE1(46-501)"
Reactome:R-HSA-8952069 "HDAC4 deacetylates RUNX3"
Reactome:R-HSA-9626962 "SIRT1 deacetylates FOXO1"
Reactome:R-HSA-9701565 "HDACs deacetylate p-STAT3 dimers"
Reactome:R-HSA-9825772 "SIRT1 deacetylates HINT1 dimer"
Reactome:R-HSA-9841847 "SIRT3 deacetylates Ac-K272,K290-FOXO3"
RHEA:21548
RHEA:58108