FlyBase Allele Report: Dmel\HDAC6[KK100215]

General Information

Symbol

Dmel\HDAC6^KK100215

Species

D. melanogaster

Name

FlyBase ID

FBal0230620

Feature type

allele

Associated gene

Dmel\HDAC6

Associated Insertion(s)

Carried in Construct

P{KK100215}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Keleman et al., 2009.8.5)

Mutagen

in vitro construct

(Keleman et al., 2009.8.5)

Progenitor genotype

Carried in construct

P{KK100215}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Keleman et al., 2009.8.5)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-KK100215

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates Parkinson's disease

modeled by Hsap\LRRK2^{R1441C.UAS.Tag:FLAG}

(Godena et al., 2014)

modeled by Hsap\LRRK2^Y1699C.UAS

(Godena et al., 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressor of

Statement

Reference

HDAC6^KK100215, Scer\GAL4^Toll-6-D42 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\LRRK2^{R1441C.UAS.Tag:FLAG}, Scer\GAL4^Toll-6-D42

(Godena et al., 2014)

HDAC6^KK100215, Scer\GAL4^Toll-6-D42 is a suppressor of abnormal locomotor behavior | adult stage phenotype of Hsap\LRRK2^Y1699C.UAS, Scer\GAL4^Toll-6-D42

(Godena et al., 2014)

Phenotype Manifest In

Suppressor of

Statement

Reference

HDAC6^KK100215, Scer\GAL4^Toll-6-D42 is a suppressor of embryonic/larval motor neuron | larval stage phenotype of Hsap\LRRK2^{R1441C.UAS.Tag:FLAG}, Scer\GAL4^Toll-6-D42

(Godena et al., 2014)

HDAC6^KK100215, Scer\GAL4^Toll-6-D42 is a suppressor of embryonic/larval motor neuron | larval stage phenotype of Hsap\LRRK2^Y1699C.UAS, Scer\GAL4^Toll-6-D42

(Godena et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Co-expression of HDAC6^KK100215 suppresses the defects in axonal transport of mitochondria seen in larval motor neurons expressing either Hsap\LRRK2^{Y1699C.Scer\UAS} or Hsap\LRRK2^{R1441C.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42.

Co-expression of HDAC6^KK100215 significantly rescues the defects in flight ability seen in flies expressing either Hsap\LRRK2^{Y1699C.Scer\UAS} or Hsap\LRRK2^{R1441C.Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^D42.

(Godena et al., 2014)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v108831

P{KK100215}VIE-260B

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

HDAC6^KK100215

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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