FlyBase Allele Report: Dmel\mir-ban[12]

General Information

Symbol

Dmel\mir-ban¹²

Species

D. melanogaster

Name

FlyBase ID

FBal0243239

Feature type

allele

Associated gene

Dmel\mir-ban

Associated Insertion(s)

Carried in Construct

Also Known As

ban¹²

Key Links

Genomic Maps

JBrowse

Allele class

amorphic allele - genetic evidence

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Yang et al., 2009)

Mutagen

Delta2-3 transposase

(Yang et al., 2009)

Progenitor genotype

mir-ban^EP3622

(Yang et al., 2009)

Cytology

Description

Has an approximately 6kb deletion including the ban core sequence.

(Yang et al., 2009)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3L:639,230..645,339 [+]

Comment:

~6kb deletion resulting from the imprecise excision of the P{EP}ban[EP3622] insertion(s). The deletion coordinates were reported as ~639230-645339.

(Yang et al., 2009)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of pupal stage

(Yang et al., 2009)

lethal - all die before end of pupal stage (with Df(3L)emc-E12)

(Yang et al., 2009)

some die during pupal stage

(Yang et al., 2009)

some die during pupal stage (with Df(3L)emc-E12)

(Yang et al., 2009)

Phenotype Manifest In

female germline stem cell | germline clone

(Xing et al., 2015)

fusome | larval stage (with Df(3L)emc-E12)

(Yang et al., 2009)

germline cell | larval stage

(Yang et al., 2009)

germline cell | larval stage (with Df(3L)emc-E12)

(Yang et al., 2009)

Detailed Description

Statement

Reference

ban¹² mutant female germline stem cell clones are lost more rapidly than controls.

(Xing et al., 2015)

Heterozygous ban¹² has no effect on eye morphology.

(Tan et al., 2012)

In 84% of 3rd instar larval gonads from ban¹² mutants, and 75% of ban¹²/Df(3L)emc-E12, primordial germ cell clusters are marked with branched fusomes that are not seen in controls.

(Yang et al., 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhancer of

Statement

Reference

ban[+]/mir-ban¹² is a non-enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Tan et al., 2012)

ban[+]/mir-ban¹² is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Tan et al., 2012)

Other

Statement

Reference

bgcn^MI06696/bgcn¹, mir-ban²⁰/mir-ban¹² has decreased cell number | oogenesis phenotype

(Zhang et al., 2024)

bgcn^MI06696/bgcn¹, mir-ban²⁰/mir-ban¹² has cell lethal | germline clone | oogenesis phenotype

(Zhang et al., 2024)

Fmr1^Δ113M, ban[+]/mir-ban¹² has female sterile phenotype

(Yang et al., 2009)

Fmr1^Δ50M, ban[+]/mir-ban¹² has female sterile phenotype

(Yang et al., 2009)

Fmr1^Δ50M, mir-ban¹² has sterile phenotype

(Yang et al., 2009)

Fmr1^Δ113M, mir-ban¹² has sterile phenotype

(Yang et al., 2009)

Phenotype Manifest In

NOT Enhancer of

Statement

Reference

ban[+]/mir-ban¹² is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Tan et al., 2012)

ban[+]/mir-ban¹² is a non-enhancer of ommatidium phenotype of Scer\GAL4^GMR.PF, Zzzz\CGG^90.UAS.EGFP

(Tan et al., 2012)

Other

Statement

Reference

bgcn^MI06696/bgcn¹, mir-ban²⁰/mir-ban¹² has female germline cell | absent phenotype

(Zhang et al., 2024)

Fmr1^Δ113M, ban[+]/mir-ban¹² has female germline stem cell phenotype

(Yang et al., 2009)

Fmr1^Δ50M, ban[+]/mir-ban¹² has female germline stem cell phenotype

(Yang et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

7.7% of ban¹²/Fmr1^Δ50M double heterozygous adult females are fertile, and 4.6% ban¹²/Fmr1^Δ113M are fertile. Double heterozygous adult females of ban¹²/Fmr1^Δ113M or ban¹²/Fmr1^Δ50M display a significant increase in the number of germaria with one or no germline stem cells, compared to controls, that progressively worsens from day 2 post-eclosion to day 12.

(Yang et al., 2009)

Xenogenetic Interactions

Statement

Reference

One copy of ban¹² has no effect on the fused ommatidia phenotype seen when Avic\GFP^{Fmr1.CGG90.E.Scer\UAS} is expressed under the control of Scer\GAL4^GMR.PF.

(Tan et al., 2012)

Complementation and Rescue Data

Rescued by

mir-ban¹²/Df(3L)emc-E12 is rescued by mir-ban^+t7.2

(Yang et al., 2009)

Comments

The lethal phenotype of ban¹²/Df(3L)emc-E12 is rescued with the introduction of ban^+t7.2.

(Yang et al., 2009)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

ban¹²

(Zhang et al., 2024, Xing et al., 2015, Tan et al., 2012, Yang et al., 2009)

mir-ban¹²

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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